介孔二氧化硅纳米颗粒作为药物载体的研究现状

材料导报

2022, Vol. 36

Issue (Z1): 21110245-6

无机非金属及其复合材料

介孔二氧化硅纳米颗粒作为药物载体的研究现状

杨惠舒¹, 李乐¹, 刘馨谣², 汤凯璇³, 乔利⁴

1 山东中医药大学药学院,济南 250355
2 山东中医药大学中医学院,济南 250355
3 山东中医药大学第一临床医学院,济南 250355
4 山东中医药大学实验中心,济南 250355

Research Status of Mesoporous Silica Nanoparticles as Drug Carriers

YANG Huishu¹, LI Le¹, LIU Xinyao², TANG Kaixuan³, QIAO Li⁴

1 School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
2 School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
3 School of Second Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
4 Shandong University of Traditional Chinese Medicine Laboratory, Jinan 250355, China

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摘要介孔二氧化硅纳米材料作为一种新型无机材料,具有表面积大、孔容积大以及表面可修饰化等优点,使其在生物医药领域被广泛应用。但单一的介孔二氧化硅存在生物降解低、性能单一等问题。为弥补这些功能缺陷,基于介孔二氧化硅纳米的一系列复合材料应运而生。介孔二氧化硅在与无机、有机材料杂化复合后,表现出可控、稳定等特征,大大改善其性能。本文简述了不同形态的介孔二氧化硅及其特性,总结了介孔二氧化硅与无机、有机材料杂化形成的复合材料的特性、研究成果及其在生物医药领域的应用情况。

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	杨惠舒
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	乔利

关键词: 无机材料介孔纳米颗粒硅基复合材料氧化硅药物载体

Abstract: As a new inorganic material, mesoporous silica nanomaterials have many advantages such as high surface area, large pore volume and surface modification, which make them widely used in the field of biomedicine. However, the single mesoporous silica has some problems such as low biodegradation and single performance. To remedy these functional defects, a series of composite materials based on mesoporous silica nanoparticles emerged. Mesoporous silica shows controllable, stable characteristics when mixed with inorganic and organic materials, which greatly improves its properties. In this paper, different forms of mesoporous silica and their properties are reviewed, and the properties, research achievements and applications of mesoporous silica composites with inorganic and organic materials are summarized.

Key words: inorganic materials mesoporous nanoparticles silicon matrix composites silicon oxide drug carrier

出版日期: 2022-06-05 发布日期: 2022-06-08

ZTFLH:

TQ460.4

基金资助: 山东省自然科学基金(ZR2019PH048);山东省大学生创新创业训练计划项目(S202110441021)

通讯作者: qiaoli0217@163.com

作者简介: 杨惠舒,现为山东中医药大学药学本科在读学生,在乔利实验师的指导下进行研究。目前主要研究领域为纳米递药系统的研究。
乔利,山东中医药大学实验中心实验师。2017年6月在同济大学化学科学与工程学院取得化学专业硕士学位。目前主要从事新型纳米给药系统研究工作。主持和参与国家级和省部级科研项目多项,在Nanoscale、Journal of Materials Chemistry B、 Colloids and Surfaces B, Biointerfaces和ACS Biomaterial Science Engineering等国内外刊物发表论文10 余篇。

引用本文:

杨惠舒, 李乐, 刘馨谣, 汤凯璇, 乔利. 介孔二氧化硅纳米颗粒作为药物载体的研究现状[J]. 材料导报, 2022, 36(Z1): 21110245-6.
YANG Huishu, LI Le, LIU Xinyao, TANG Kaixuan, QIAO Li. Research Status of Mesoporous Silica Nanoparticles as Drug Carriers. Materials Reports, 2022, 36(Z1): 21110245-6.

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http://www.mater-rep.com/CN/ 或 http://www.mater-rep.com/CN/Y2022/V36/IZ1/21110245

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