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材料导报  2024, Vol. 38 Issue (15): 23070035-8    https://doi.org/10.11896/cldb.23070035
  高分子与聚合物基复合材料 |
基于纤维芯层流体力学方法制备聚合物功能微球研究进展
杨昊川1,2, 陶光明3, 陈东2,4, 董文坤2,4, 凌世生2,4, 乔旭升1,2,*, 樊先平1,2
1 浙江大学材料科学与工程学院,杭州 310027
2 浙江大学-安旭生物联合研发中心,杭州 310011
3 华中科技大学武汉光电国家研究中心,武汉 430074
4 杭州安旭生物科技有限公司,杭州 310011
Research Progress on Polymer Functional Microspheres Preparation Through Fiber Core Based Hydrodynamic Method
YANG Haochuan1,2, TAO Guangming3, CHEN Dong2,4, DONG Wenkun2,4, LING Shisheng2,4, QIAO Xusheng1,2,*, FAN Xianping1,2
1 School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China
2 Zhejiang University-Anxu Biological Joint R & D Center, Hangzhou 310011, China
3 Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China
4 Hangzhou Anxu Biotechnology Co., Ltd., Hangzhou 310011, China
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摘要 聚合物复合微球在医药、传感、光学、显示等领域,特别是在医药领域的临床诊断、病理成像和药物输送等方面具备重要应用价值。但是,聚合物复合微球的合成路线复杂、加工效率低下,常规工艺通常难以兼顾微球粒径单分散性、生产成本、产量等综合要求。近年来,纤维芯层流体力学方法依据纤维内发生的流体界面不稳定性(PRI)现象,可在微纳米尺度制备具有高度单分散性的聚合物微球,同时成本可控,适合批量生产。本文综述了流体界面不稳定性原理、纤维芯层PRI方法制备工艺、功能微球和结构微球的纤维芯层PRI方法制备等方面的最新进展,以及针对纤维芯层PRI方法的最新改进。
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杨昊川
陶光明
陈东
董文坤
凌世生
乔旭升
樊先平
关键词:  纤维  聚合物  流体界面不稳定性  微纳米  功能微球  结构微球    
Abstract: Polymer composite microspheres have important applications in the fields of medicine, sensing, optics and display, especially in clinical diagnosis, pathological imaging and drug delivery in the field of medicine. However, due to the complex synthesis route and low processing efficiency, conventional technologies are often difficult to take into account the good particle size dispersion, low production cost and high yield of microspheres. In recent years, based on Plateau-Rayleigh fluid interface instability (PRI) in fibers, laminar hydrodynamic methods can prepare highly monodisperse polymer microspheres at micro or nano scale with controllable cost and considerable yield. In this paper, the principle of fluid interface instability, the preparation process of fiber core layer PRI method, the preparation of functional microspheres and structural microspheres of fiber core layer PRI method and the improvement of fiber core layer PRI method are reviewed.
Key words:  fiber    polymer    fluid interface instability    micro-nano    functional microsphere    structural microsphere
出版日期:  2024-08-10      发布日期:  2024-08-29
ZTFLH:  TQ021.1  
基金资助: 浙江省科技厅“领雁”研发攻关项目(2022C01142)
通讯作者:  * 乔旭升,浙江大学材料科学与工程学院副教授、博士研究生导师。2007年于浙江大学获工学博士学位,毕业后留校任教至今。目前,主要从事发光玻璃与玻璃陶瓷、生物荧光标记材料与材料计算等方面的教学科研工作。qiaoxus@zju.edu.cn   
作者简介:  杨昊川,2022年6月于山东大学获得工学学士学位,现为浙江大学材料科学与工程学院硕士研究生,在樊先平教授、乔旭升副教授的指导下开展有机无机复合聚合物功能微球的课题研究。
引用本文:    
杨昊川, 陶光明, 陈东, 董文坤, 凌世生, 乔旭升, 樊先平. 基于纤维芯层流体力学方法制备聚合物功能微球研究进展[J]. 材料导报, 2024, 38(15): 23070035-8.
YANG Haochuan, TAO Guangming, CHEN Dong, DONG Wenkun, LING Shisheng, QIAO Xusheng, FAN Xianping. Research Progress on Polymer Functional Microspheres Preparation Through Fiber Core Based Hydrodynamic Method. Materials Reports, 2024, 38(15): 23070035-8.
链接本文:  
http://www.mater-rep.com/CN/10.11896/cldb.23070035  或          http://www.mater-rep.com/CN/Y2024/V38/I15/23070035
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