Abstract: Antibiotic-independent antibacterial surfaces are important research to avoid the problem of antimicrobial-resistant bacteria in the field of biomaterial and device design. Unfortunately, existing surface antibacterial strategies still have shortcomings, such as cumbersome steps and harsh reaction conditions. Therefore, in this study, a broad-spectrum antibacterial coating containing zinc polydopamine (PDA@Zn)was constructed in a ‘one-step’ process using dopamine and zinc sulfate (ZnSO4)as raw materials under normal temperature and aqueous phase conditions. The results of water contact angle, thickness of coating and XPS confirmed the successful construction of the PDA@Zn coating. The Zn in the coating is ligand-bound to the catechol functional group in PDA in the form of Zn2+;the surface Zn2+ density can be controlled by adjusting the feeding concentration of ZnSO4. The results of antibacterial experiments showed that the PDA@Zn/1 constructed at a ZnSO4 feeding concentration of 1 mg/mL had excellent bactericidal effect, with 99.7% and 99.3% antibacterial rates against E.coli and S.epidermidi, respectively. The results of in vitro cell culture assay showed that the RGR of L929 on PDA@Zn/1 coating at 24 h and 72 h were 63.63% and 48.32%, respectively, with some cytotoxicity. This method provides an efficient and simple surface antibacterial strategy, but its biocompatibility needs to be further improved.
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2023, Vol. 37 
