Tissue Adhesive Bacteriostasis of Polysaccharide Polyelectrolyte Electrostatic Assembly High Strength Hydrogel Membrane
WU Qiang1, SHANG Lingli1, LI Xuefeng1,2,*, ZHANG Gaowen1,2, HUANG Yiwan1,2, LONG Shijun1,2
1 School of Materials Science and Engineering, Hubei University of Technology, Wuhan 430068, China 2 Hubei Provincial Key Laboratory of Green Materials for Light Industry, Hubei University of Technology, Wuhan 430068, China
Abstract: Hydrogels composed of cross-linked hydrophilic polymers and a large amount of water have good biocompatibility and wide application prospects in biomedical fields. However, high water content leads to low bulk strength (tensile strength mostly below 0.1 MPa), and the formation of hydration layer on the surface makes it difficult to firmly adhere to the surface of the substrate. In this work, chitosan quaternary ammonium salt/oxidized hyaluronic acid (HACC/HA-CHO) polyelectrolyte composite hydrogel membrane was prepared by self-assembly using two kinds of polysaccharide polymers with opposite charges. Since the HACC molecular chain with positive charge and primary amino group and HA-CHO molecular chain with negative charge and aldehyde group can form strong electrostatic interaction between opposite charges, and Schiff base reaction can occur between the primary amino group and aldehyde group. The synergistic effect of the two makes the HACC/HA-CHO hydrogel membrane have excellent tensile strength (7.67 MPa). In addition, the fresh biological tissue surface is also rich in negative charges and primary amino groups, and the hydrogel membrane can also form a strong interaction with the biological tissue at the interface and produce a good bonding effect. After introducing 4-carboxyphenyl porphyrin iron metal cluster (Fe-TCPP), Fe-TCPP@HACC/HA-CHO hydrogel membrane was obtained with excellent bacteriostatic performance (the diameter of bacteriostatic zone was 14.8 mm). This work provides guidance for the application of polyelectrolyte composite hydrogel membranes in the field of biomedical antifouling.
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2024, Vol. 38 
