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材料导报  2021, Vol. 35 Issue (Z1): 104-107    
  无机非金属及其复合材料 |
HAP-TCP复合生物陶瓷浆料的激光3D打印及性能研究
王志勇1, 蔡志祥1, 刘国承2, 孙智龙1, 张铁3
1 武汉因泰莱激光科技有限公司,武汉 430000
2 武汉理工大学,现代汽车零部件技术湖北省重点实验室,武汉 430070
3 湖北联结生物材料有限公司,武汉 430000
Laser 3D Printing and Properties of HAP-TCP Composite Bioceramic Materials
WANG Zhiyong1, CAI Zhixiang1, LIU Guocheng2, SUN Zhilong1, ZHANG Tie3
1 Wuhan Intelligent Laser Technology Co. LTD,Wuhan 430000, China
2 Hubei Key Laboratory of Advanced Technology for Automotive Components, Wuhan University of Technology, Wuhan 430070, China
3 Hubei Lianjie Biological Materials Co. LTD,Wuhan 430000, China
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摘要 羟基磷灰石(HAP)和磷酸三钙(TCP)是临床上常用的骨修复支架材料,将两者复合可以得到成型精度高、成骨性好、降解速度快的复合材料。本工作采用激光3D打印机打印,可以满足不规则人工骨的成型要求。将HAP-TCP复合陶瓷粉体与丙烯酸酯单体及其他助剂混合后进行球磨,得到陶瓷浆料。通过对打印工艺的研究确定了最佳固化深度为分层厚度的3~4倍,最佳扫描速度为2 000 mm/s,并通过TG-DSC曲线的分析,得到生坯的烧结温度范围,通过对几种烧结温度的测试,确定了最佳烧结温度为1 000 ℃。最后在最佳工艺参数下打印支架,通过SEM的观察可知晶相结合紧密,最后通过动物实验可知,支架植入老鼠颅骨后,大鼠未见死亡及不良反应症状,且能看到有成骨现象。
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王志勇
蔡志祥
刘国承
孙智龙
张铁
关键词:  激光3D打印  复合生物陶瓷  打印工艺  动物实验    
Abstract: Hydroxyapatite (HAP) and tricalcium phosphate (TCP) are scaffold materials that are widely used in bone repair. The composite materials of HAP and TCP can obtain high molding accuracy, good osteogenesis and fast degradation. A SLA-system was used in this study to print green part, this system can meet the requirements of irregular artificial bone formation. The HAP-TCP composite ceramic powders were mixed with an acrylic resin and other additives, then ball-milling was performed to obtain a ceramic slurry. Through the study of printing process, the optimal curing depth is determined to be 3—4 times of the layer thickness and the optimal scanning speed is 2 000 mm/s. The sintering temperature range of the green part was obtained through the analysis of the TG-DSC curve. By testing several sintering temperatures, we confirmed that the optimal sintering temperature was 1 000 ℃. Finally, under the best process parameters, we printed the ceramic scaffold. Through the SEM observation, we could see the tightly combined crystals. Finally, animal experiments showed that after the scaffold was implanted in the skull of the mouse. And we did not see any symptoms of death and adverse reactions of the mouse, and we also saw the osteogenesis phenomenon.
Key words:  laser 3D printing    compound bioceramic    printing process    animal experiment
                    发布日期:  2021-07-16
ZTFLH:  TB39  
基金资助: 国家重点研发项目(2018YFB1106700)
通讯作者:  liugch@whut.edu.cn   
作者简介:  王志勇,2016年6月毕业于武汉科技大学,取得工程硕士学位。从2017年11月至今,就职于武汉因泰莱激光科技有限公司,主要从事陶瓷激光3D打印的研究。刘国承,毕业于华中科技大学材料科学与工程专业,工学博士学位。目前在武汉理工大学汽车工程学院车辆工程专业工作,讲师。主要从事复合材料的增材制造技术、机械零部件再制造技术等方向的研究。
引用本文:    
王志勇, 蔡志祥, 刘国承, 孙智龙, 张铁. HAP-TCP复合生物陶瓷浆料的激光3D打印及性能研究[J]. 材料导报, 2021, 35(Z1): 104-107.
WANG Zhiyong, CAI Zhixiang, LIU Guocheng, SUN Zhilong, ZHANG Tie. Laser 3D Printing and Properties of HAP-TCP Composite Bioceramic Materials. Materials Reports, 2021, 35(Z1): 104-107.
链接本文:  
http://www.mater-rep.com/CN/  或          http://www.mater-rep.com/CN/Y2021/V35/IZ1/104
1 Wei G ,Ma P X. Biomaterials, 2004,25(19),4749.
2 Fellah B H,Gauthier O,Weiss P.Biomaterials,2008,29(9),1177.
3 郭朝邦,金海波,李广龙,等.人工晶体学报,2009(38),263.
4 纪宏超,张雪静,裴未迟,等.材料工程,2018, 46(7),19.
5 卢秉恒, 李涤尘.机械制造与自动化,2013, 42(4),1.
6 杨媛丽, 王永祯,王爱玲.材料开发与应用, 2006, 21(6), 8.
7 Schek R M,Taboas J M,Segvich S J,et al. Tissue Engineering,2004,10,1376.
8 Park S H, Park D S, Shin J W, et al. Journal of Materials Science: Materials in Medicine, 2012,23,2671.
9 刘春春,张永志,晏恒峰,等.应用激光,2017,37(3),430.
10 张航,许宋峰,熊胤泽,等.机械工程学报,2019,55(15),81.
11 杨中.基于羟基磷灰石的3D打印和烧结强化人工骨技术研究.硕士学位论文,重庆大学,2015
12 黄威.基于MAM挤出沉积成型制备HA骨组织支架工艺研究.硕士学位论文,华中科技大学,2013.
13 马云海,尚文博,范雪莹,等.吉林大学学报,2015,45(4),1367.
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