Abstract: The biocompatibility of electrode-tissue interface is a crucial factor that influences the long-term performances of neural prosthesis. The modification of the electrode surface can significantly improve the biocompatibility at the implant site. Iridium oxide films were formed on the surface of titanium substrate by RF magnetron sputtering and cyclic voltammetry. Modified by dopamine and laminin, the iridium oxide/polydopamine/laminin biomimetic layer was prepared. The physical and chemical characterizations of the biomimetic layer show that the electrochemical properties and hydrophilicity are significantly improved. The layer is stable, without cytotoxicity. Besides, the layer promotes cell adhesion of PC12.
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2018, Vol. 32 
