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材料导报  2022, Vol. 36 Issue (18): 20080069-11    https://doi.org/10.11896/cldb.20080069
  无机非金属及其复合材料 |
功能化SBA-15介孔二氧化硅的制备及在药物递送系统中的应用进展
张文君†, 吕江维†,*, 陈威, 王鹏光
哈尔滨商业大学药学院,哈尔滨 150076
Preparation of Functionalized SBA-15 Mesoporous Silica and Its Application in Drug Delivery System
ZHANG Wenjun†, LYU Jiangwei†,*, CHEN Wei, WANG Pengguang
School of Pharmacy, Harbin University of Commerce, Harbin 150076, China
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摘要 介孔二氧化硅具有孔径均匀可调、孔容大、表面积大、表面容易功能化修饰、无毒、生物相容性好等优点,是一种理想的药物载体材料,可以用于构建药物递送系统(Drug delivery system,DDS),解决传统载体如脂质体、聚合物胶束等存在的稳定性差、分散不均匀、药物过早降解和消除等问题。
SBA-15是一种新型的二氧化硅介孔分子筛,以其较大的孔径、较厚的孔壁、高比表面积以及有序孔道等特征被广泛应用于DDS。SBA-15表面存在大量硅烷醇基,表面活性高,利用适当的官能团、金属离子或其他材料等对其孔口、孔道内外表面进行修饰,可以实现负载药物的可控释放、多功能智能化响应及抗癌药物的靶向治疗等多种功能,最大程度地发挥药物的治疗效果,有效降低药物的毒副作用,提高药物的生物利用度。
近年来,经过功能化修饰的SBA-15在DDS中的应用主要体现在:(1)提高药物溶解度及溶出速率。选择合适的功能化试剂改变SBA-15表面性质,进而改变载体表面与药物分子之间的相互作用,增加药物的吸附量,从而改善难溶性药物的溶解度和溶出速率。(2)作为药物缓释载体。通过有机基团、金属或金属氧化物等的表面修饰,以增强药物与载体表面之间的作用力,延长药物的释放。(3)作为药物控释载体。通过构建配体修饰的靶向型DDS、内部或外部刺激响应型DDS实现药物的可控释放。除此以外,SBA-15在骨组织修复、基因治疗、医学成像、伤口敷料等生物医学工程方面也有广泛的应用。
本文介绍了功能化SBA-15介孔二氧化硅的制备方法、类型、特点,归纳了其在DDS中的应用及最新研究进展,以期为功能化介孔二氧化硅载体的实际应用提供参考。
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张文君
吕江维
陈威
王鹏光
关键词:  SBA-15  介孔二氧化硅  功能化修饰  药物递送系统    
Abstract: Mesoporous silica is an ideal drug carrier that can be used in drug delivery system (DDS)due to its unique characterizations such as uniform and tunable pore size, large pore volume and surface area, easy functionalization, non-toxicity and good biocompatibility. It can solve the problems of traditional liposomes and polymer micelles including poor stability, uneven dispersion, premature drug degradation and elimination.
As a novel mesoporous molecular sieve, SBA-15 has been widely used in DDS for its large pore size, thick pore wall, high specific surface area and orderly channel. Since a large number of silanol groups with high activity are located on the surface of SBA-15, it is easy to modify its orifice, inner and outer surface of the channel by suitable functional groups, metal ions or other materials. The functionalized SBA-15 can realize the controlled release of drugs, multi-function intelligent response and targeted treatment of anticarcinogens, which finally accomplishes the maximization of the therapeutic effect, reduction of the side effects and improvement of the bioavailability of drugs.
In recent years, the applications of functionalized SBA-15 in DDS are mainly as follows: (i) improvement of the solubility and dissolution rate of drugs. For this purpose, an appropriate reagent for functionalization should be selected to modify the surface characterization of SBA-15, which results in changing the interaction between the carrier surface and drug molecules. This interaction promotes the drug adsorption and improves the solubility and dissolution rate of insoluble drugs. (ii) Uses as carriers for sustained release of drugs. The surface of SBA-15 can be modified by organic groups, metals or metal oxides to enhance the force between drugs and carrier surfaces, thus prolonging the drug release. (iii) Uses as carriers for controlled release of drugs. A controllable drug release can be achieved by constructing targeted DDS with ligand modification and internal or external stimulus-responsive DDS. In addition, SBA-15 is also widely applied in biomedical engineering, bone tissue repair, gene therapy, medical imaging, wound dressings, etc.
This review introduces the preparation methods, types and characteristics of functionalized SBA-15 mesoporous silica, and also summarizes its applications and the latest research progress in drug delivery, aiming to provide a reference for the practical application of functionalized mesoporous silica carriers.
Key words:  SBA-15    mesoporous silica    functional modification    drug delivery system
收稿日期:  2022-09-25      出版日期:  2022-09-25      发布日期:  2022-09-26
ZTFLH:  R944  
基金资助: 2019年哈尔滨商业大学青年人才专项计划项目(2019CX12)
通讯作者:  *pp198259@163.com   
作者简介:  †共同第一作者
张文君,哈尔滨商业大学药学院副教授、硕士研究生导师。2005年本科毕业于黑龙江中医药大学药学院,2011年在沈阳药科大学中药制剂学专业取得博士学位,2016—2019年在南京医科大学进行博士后研究工作,目前主要研究领域是新型药物传输系统的研究,发表专业相关论文30余篇。吕江维,哈尔滨商业大学药学院副教授、硕士研究生导师。2005年本科毕业于哈尔滨工业大学,2010年在哈尔滨工业大学取得博士学位,2011—2014年在哈尔滨工业大学进行电催化材料的博士后研究工作。目前主要从事介孔材料的研究工作。主持完成国家自然科学基金、中国博士后科学基金、省教育厅基金等多个项目,发表专业相关论文30余篇。
引用本文:    
张文君, 吕江维, 陈威, 王鹏光. 功能化SBA-15介孔二氧化硅的制备及在药物递送系统中的应用进展[J]. 材料导报, 2022, 36(18): 20080069-11.
ZHANG Wenjun, LYU Jiangwei, CHEN Wei, WANG Pengguang. Preparation of Functionalized SBA-15 Mesoporous Silica and Its Application in Drug Delivery System. Materials Reports, 2022, 36(18): 20080069-11.
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