Matrix Vesicles and Their Role in Bone Mineralization Process
HONG Jiadan, HE Liyong, YANG Huifang, WEI Luxi, PANG Dongwen, DENG Chunlin
1 School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641; 2 National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006
Abstract: The initial deposition of bone mineral occurs within matrix vesicles (MVs). Calcium phosphate deposition within MVs is triggered by the transmembrane transport and aggregation of calcium & phosphate ions within the MVs lumina through membrane proteins and enzymes when local concentration of calcium & phosphate ions approaches to the certain value. The existence form of calcium phosphate includes amorphous calcium phosphate (ACP), octacalcium phosphate (OCP), and hydroxyapatite (HA). MVs play an important role in initiating bone mineralization process, including controlling calcium & phosphate ions homeostasis, regulating the inorganic phosphate/inorganic pyrophosphate (Pi/PPi) ratio in the intra- and extra-cellular fluid and managing mineral nucleation, etc. This paper introduces the biogenesis, molecular components and extraction method of MVs, illuminates the role and the kinetics of MVs in bone mineralization process. Finally, the research progress of biomimetic mineralization using synthetic phospholipid vesicles as an in vitro mineralization model are discussed.
洪佳丹,何丽泳,杨慧方,韦路希,庞栋文,邓春林. 基质囊泡及其在骨矿化过程中的作用[J]. 《材料导报》期刊社, 2018, 32(11): 1827-1833.
HONG Jiadan, HE Liyong, YANG Huifang, WEI Luxi, PANG Dongwen, DENG Chunlin. Matrix Vesicles and Their Role in Bone Mineralization Process. Materials Reports, 2018, 32(11): 1827-1833.
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