通过仿生矿化修复人体牙齿结构

doi:10.11896/cldb.23030040

材料导报

2024, Vol. 38

Issue (15): 23030040-13 https://doi.org/10.11896/cldb.23030040

无机非金属及其复合材料

通过仿生矿化修复人体牙齿结构

潘二才, 姜志超, 黄嘉辉, 马玉荣^*

北京理工大学化学与化工学院,北京 100081

Human Tooth Structures Restoration by Biomineralization

PAN Ercai, JIANG Zhichao, HUANG Jiahui, MA Yurong^*

School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China

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摘要牙齿结构损伤、缺失导致的龋齿和牙齿过敏等问题严重影响了人们的日常生活。众多学者针对这些问题提出了各式各样的解决方案,但是最终结果与原生牙齿结构相比还是不尽人意。生物矿化是研究生物体内的硬组织(如牙齿、骨骼和贝壳等)的形成过程。一般地,这类硬组织是由有机生物分子调控无机矿物形成的多级、有序且能供生命体实现特定功能的有机-无机复合材料。近年来许多研究人员通过模拟牙齿自然矿化的过程,仿生设计和合成出人工纳米材料来修复牙釉质、牙本质等牙齿结构的方法取得了重要成效。与传统的使用激光、有机粘合剂等修复手段相比,仿生矿化方法所修复的牙齿部位在组成、结构和力学性能上与原生牙齿相近,具有无损、生物兼容、抗菌防污等优点。因此仿生矿化方法有望从根本上解决牙齿结构修复的难题。现对牙齿结构、牙齿脱敏治疗方法、牙齿结构仿生再矿化和牙齿修复材料的研究现状及进展进行综述。

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关键词: 生物矿化纳米材料牙齿过敏牙釉质牙本质

Abstract: Dentin hypersensitivity, dental caries, and tooth wear and fracture severely influence human daily life. A lot of strategies have been applied to solve these problems by different researchers. Biomineralization refers to the processes by which organisms form hard tissues (such as teeth, bone, and shells et al.). Generally, these hard tissues are regular, hierarchically structured, and functional organic-inorganic composites which formed by biomacromolecules controlling the nucleation and growth of inorganic minerals. Recently, many researchers mimic the natural development and biomineralization of teeth to regenerate and repair the natural hard dental tissues, which have great importance in biomedical applications. The biomimetic restorative approach can restore the tooth to its natural state in composition, structure, and mechanical properties compared with traditional restoration such as using lasers and organic bonding agents. What’s more, it is harmless, biocompatible, and can combine with antibacterial and anti-fouling properties. Therefore, the biomimetic restorative approach will fundamentally solve these dental problems. Here we review recent progress towards tooth structure, desensitization, remineralization, and its restorative materials.

Key words: biomineralization nanomaterials dentin hypersensitivity enamel dentine

出版日期: 2024-08-10 发布日期: 2024-08-29

ZTFLH:

O69

基金资助: 国家自然科学基金(21877009)

通讯作者: * 马玉荣,2017/09至今,北京理工大学化学与化工学院教授、博士研究生导师;2008/05—2017/08,北京大学化学与分子工程学院副教授、博士研究生导师;2006/05—2008/04,以色列魏兹曼科学院结构生物系博士后;2004/10—2006/04,德国马普学会胶体与界面研究所胶体化学部博士后。发现多级有序结构、非晶态组分在晶体颗粒中的掺杂及颗粒基元的晶体取向高度一致性等结构特点对碳酸钙生物矿物的优异力学性能有重要贡献。目前在国内外学术期刊上发表论文80篇余篇,以第一和通信作者发表SCI文章60余篇,包括PNAS、Angew.Chem.Int.Ed.、Adv.Mater.、Adv.Funct.Mater. 等。yurong.ma@bit.edu.cn

作者简介: 潘二才,2020年6月于广西大学获得工学学士学位。现为北京理工大学化学与化工学院硕士研究生,在马玉荣教授的指导下进行研究。目前主要研究领域为生物矿物和仿生矿化。

引用本文:

潘二才, 姜志超, 黄嘉辉, 马玉荣. 通过仿生矿化修复人体牙齿结构[J]. 材料导报, 2024, 38(15): 23030040-13.
PAN Ercai, JIANG Zhichao, HUANG Jiahui, MA Yurong. Human Tooth Structures Restoration by Biomineralization. Materials Reports, 2024, 38(15): 23030040-13.

链接本文:

http://www.mater-rep.com/CN/10.11896/cldb.23030040 或 http://www.mater-rep.com/CN/Y2024/V38/I15/23030040

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