Induction and Regulation of Chiral Calcium Carbonate Biominerals by Chiral Amino Acids
JIANG Wenge1,*, LI Yan’an1, XING Yi1, LI Haibin1,2, SONG Jianwei1, LIU Yue1
1 Tianjin Key Laboratory of Molecular Optoelectronic Sciences, and Tianjin Collaborative Innovation Center of Chemical Science & Engineering, Department of Chemistry,Tianjin University, Tianjin 300072, China 2 Key Laboratory of Resource Chemistry and Eco-environmental Protection in Tibetan Plateau of State Ethnic Affairs Commission, School of Chemistry and Chemical Engineering, Qinghai Minzu University, Xining 810007, China
Abstract: Chiral biologic minerals, widely found in nature, play an important role in the origin of life, biological evolution, pathology and material science. Therefore, the exploration of the generation mechanism of biological minerals has gradually become a hot research field in modern times. In the process of biomineralization, related chiral protein molecules realize the regulation of biominerals through their chiral amino acid residues. In this work, starting from acidic, neutral and alkaline amino acids which constitute the chiral mineralized proteins, we simulated the chiral environment of the growth of biological calcium carbonate minerals to induce the synthesis of chiral calcium carbonate (vaterite) biological mine-rals. The effect of various chiral amino acids in the formation of chiral calcium carbonate was revealed by means of optical microscopy, scanning electron microscopy and X-ray diffraction. Acid amino acid molecules regulated the chiral structure of vaterite, while alkaline amino acid and neutral amino acid induced the formation of vaterite phase. This study establishes a new theoretical model for the production process of chiral biomaterials and will promote the synthesis and development of chiral biomaterials.
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2023, Vol. 37 
