A State-of-the-art Review on Fluorescent Carbon Quantum Dots: Fabrication,Characterization and Potential in Cancer Therapy
YANG Kun1, WANG Chunlai1, DING Sheng1, LIU Changjun1,2, TIAN Feng1, LI Fan1
1 Institute of Medical Support Technology, Academy of Military Sciences, Tianjin 300161 2 National Engineering Research Center for Biological Protective Equipment, Tianjin 300161
Abstract: Carbon quantum dots (CDs or C-dots) are novel fluorescent nano-materials mainly composed of carbon. As a member of nanomaterials, CDs show the common surface and interface effects, hence the surface of CDs is greatly active and prone to be modified. Thanks to the small size effect and quantum size effect, CDs are also endowed with excellent fluorescence performance, exhibiting high quantum yield, stability and controllable properties. In addition, the excellent water solubility, low cytotoxicity, satisfactory biocompatibility, small particle size and molecular weight are favorable for the application of CDs in vivo. The above mentioned outstanding properties of CDs enable the widespread applications of CDs in diverse fields, including tumor imaging, detection, targeting and therapy. Just from the perspective of tumor therapy, the applications of CDs have deeply penetrated in traditional and emerging approaches already. Taking advantages of CDs, researchers commonly employ nano-drug delivery system to optimize the chemotherapy. It uses nanomaterials as the basic unit, then the drugs are absorbed or encapsulated onto the nano-carriers through physical or chemical connection, and finally to achieve a better anticancer effect by the special properties of nano-carriers. Accordingly, CDs play a significant role in chemotherapy process due to their excellent performance. Specifically speaking, CDs can enhance the therapeutic effect by improving the water solubility of drug, reduce the da-mage of drugs to the normal cells by improving the targeting ability to the lesion, prolong the retention time of the drug, and realize the intelligent and efficient drug release. Furthermore, the characteristic of photothermal conversion and photoluminescence properties of CDs have also paved the way for extensive application of CDs in many emerging therapeutic approaches, such as photothermal therapy and photodynamic therapy. As regard to hyperthermia treatment, CDs can significantly improve the safety and efficiency. In photodynamic therapy, CDs contribute to improve the solubility, quantum yield of photosensitizer, penetration depth of light source and oxygen supply around cancerous tissue. The CDs in multiple treatments can also boost the therapeutic effect to the maximum. In this article, we introduce the synthesis approaches and latest progress in CDs preparation, summarize the excellent properties of CDs in tumor therapy, and put emphasis on frontier application of CDs in cancer therapy including photodynamic therapy, photothermal therapy and chemotherapy.
杨焜, 王春来, 丁晟, 刘长军, 田丰, 李钒. 荧光碳量子点:合成、特性及在肿瘤治疗中的应用[J]. 材料导报, 2019, 33(9): 1475-1482.
YANG Kun, WANG Chunlai, DING Sheng, LIU Changjun, TIAN Feng, LI Fan. A State-of-the-art Review on Fluorescent Carbon Quantum Dots: Fabrication,Characterization and Potential in Cancer Therapy. Materials Reports, 2019, 33(9): 1475-1482.
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