The Review and Prospect of Cadiopulmonary Bypass Coating Materials
JIANG Tao1, WANG Ruibin1, HUO Feng2
1 Guangdong Shunde Industrial Design Institute Guangdong Shunde Innovative Design Institute, Foshan 528311; 2 Department of Hepatobiliary Surgery, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010
Abstract: During the past several decades, the progress in techniques such as extracorporeal procedures including haemodialysis, cardiopulmonary bypass, as well as orthopedic, vascular and reconstructive surgery promoted the use of artificial materials in contact with living tissue dramatically. The evolution has highlighted the problems of biocompatibility. In the case of blood contact with any foreign materials induces activation of several host response defense mechanisms such as haemostatic mechanism, with consequences as thrombus formation, occlusion of medical device and embolization, which greatly limits the application of materials in medicine. Therefore, improving the biocompatibility of materials in cadiopulmonary Bypass system, especially the hemocompatibility, is the key to solve this problem. At present, the most effective and widely used technique for improving the biocompatibility of materials is surface coating technology. This paper reviews three main ways to improve the hemocompatibility of materials: build biological inert surface, bionic surface, and load bioactive substances, at the same time introduce several surface coating technologies and their clinical application, such as albumin, polyethylene oxide, SMA, PEMA, phosphorylcholine, glycosaminoglycan, heparin, hirudin, dipyridamole, and others. In the end, give a prospect of improving the hemocompatibility of cadiopulmonary bypass system.
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2018, Vol. 32 
