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材料导报  2019, Vol. 33 Issue (Z2): 542-546    
  高分子与聚合物基复合材料 |
超临界二氧化碳辅助制备β-环糊精-药物包合物的研究进展
王景昌1,2, 赵宇1,2, 苗宏雨1,2, 赵启成1,2, 詹世平1,2
1 大连大学环境与化学工程学院,大连 116622;
2 辽宁省化工环保工程技术研究中心,大连 116622
Preparation of β-cyclodextrin-drug Inclusion Complex Aided by SupercriticalCarbon Dioxide
WANG Jingchang1,2, ZHAO Yu1,2, MIAO Hongyu1,2, ZHAO Qicheng1,2, ZHAN Shiping1,2
1 College of Environmental & Chemical Engineering, Dalian University, Dalian 116622;
2 Chemical and Environmental Protection Engineering Research Technology Center, Dalian 116622
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摘要 β-环糊精是一种具有良好生物相容性的可降解生物材料,被广泛应用于医药、医疗和环境等领域。本文首先阐述了β-环糊精的基本性质及其在药剂学相关领域的应用,简要论述了超临界流体作为绿色溶剂的一些特点及其在药物制剂中的应用情况,介绍了超临界二氧化碳制备β-环糊精包合物的一些研究方法和结果,最后对β-环糊精的应用和超临界流体的研究发展方向进行了展望。
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王景昌
赵宇
苗宏雨
赵启成
詹世平
关键词:  β-环糊精  超临界二氧化碳  β-环糊精包合物  药物微粒    
Abstract: Due to its good biocompatibility and biodegradability, β-cyclodextrin is widely used in the fields of the drug, medicine and environment and so on. In this paper, the basic properties of β-cyclodextrin and its application in pharmaceutical fields were described, and the characteristics of supercritical fluid as a green solvent and its application in pharmaceutical preparations were briefly discussed. Some research methods and results on β-cyclodextrin inclusion complex prepared by supercritical carbon dioxide were introduced. Finally, the development direction on the application of β-cyclodextrin and the research of supercritical fluid were prospected.
Key words:  β-cyclodextrin    supercritical carbon dioxide    β-cyclodextrin inclusion complex    drug microparticles
               出版日期:  2019-11-25      发布日期:  2019-11-25
ZTFLH:  TB34  
基金资助: 国家自然科学基金(21676038)
通讯作者:  zhanshiping@dlu.edu.cn   
作者简介:  王景昌,大连大学环境与化学工程学院教授,硕士研究生导师,以第一作者在国内外学术期刊上发表论文20余篇,申请国家发明专利7项,其中授权5项。研究方向为功能高分子材料。
詹世平,大连大学环境与化学工程学院教授,博士研究生导师,功能高分子材料学科方向团队负责人。在国内外学术期刊上发表研究论文50余篇,获得授权国家发明专利18项。主要研究方向包括:超临界流体技术制备聚合物微粒;靶向聚合物载药微粒药物释放性能;生物医用聚合物材料制备等。
引用本文:    
王景昌, 赵宇, 苗宏雨, 赵启成, 詹世平. 超临界二氧化碳辅助制备β-环糊精-药物包合物的研究进展[J]. 材料导报, 2019, 33(Z2): 542-546.
WANG Jingchang, ZHAO Yu, MIAO Hongyu, ZHAO Qicheng, ZHAN Shiping. Preparation of β-cyclodextrin-drug Inclusion Complex Aided by SupercriticalCarbon Dioxide. Materials Reports, 2019, 33(Z2): 542-546.
链接本文:  
http://www.mater-rep.com/CN/  或          http://www.mater-rep.com/CN/Y2019/V33/IZ2/542
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