Abstract: As a novel transdermal drug delivery system, dissolvable microneedle has broken the limitations of traditional transdermal formulations which are not able to deliver macromolecular. Besides the aspect of macromolecular delivery, dissolvable microneedles have numerous advantages including small enough to avoid causing pain, minimal skin trauma, no bleeding or introduction of pathogens, good biocompatibility, easy to self-administration, etc. The study of dissolvable microneedle has recently become a hot topic. The choice of matrix materials directly affects the preparation process of microneedle, as well as the properties of skin puncturing and drug releasing. This paper introduces the research status of dissolvable microneedle, classifies and introduces the matrix materials, then summarizes the use of their compounds. The properties of ductile materials and brittle materials and their synergistic effects after composite are introduced as well. Finally, the existing problems and research directions in this field are discussed.
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2017, Vol. 31 
