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材料导报  2025, Vol. 39 Issue (16): 24070168-13    https://doi.org/10.11896/cldb.24070168
  无机非金属及其复合材料 |
微反应器在药物、载药递释材料和诊疗药物制备领域应用的研究进展
齐亚兵1,*, 王康康1, 吴子波2,*, 党方方1
1 西安建筑科技大学化学与化工学院,西安 710055
2 西南化工研究设计院有限公司,成都 610225
Applicative Research Progress on Preparation of Drugs,Drug Loading and Releasing Materials,and Diagnostic and Therapeutic Drugs in Microreactors
QI Yabing1,*, WANG Kangkang1, WU Zibo2,*, DANG Fangfang1
1 School of Chemistry and Chemical Engineering, Xi’an University of Architecture and Technology, Xi’an 710055, China
2 Southwest Institute of Chemical Co., Ltd., Chengdu 610225, China
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摘要 与传统釜式反应器相比,微反应器的传热传质性能更好,安全性更高,反应过程可精确控制。因此,微反应器可作为一个高效和便捷的反应平台,应用于有机合成药物及中间体、纳米药物、载药递释材料和诊疗药物的制备过程中。本文全面地介绍了微反应器在有机合成药物及中间体、纳米药物、载药递释材料和诊疗药物制备领域的研究进展,系统地解析了在微反应器内制备有机合成药物及中间体、纳米药物、载药递释材料和诊疗药物过程中的影响因素,展望了微反应器在有机合成药物及中间体、纳米药物、载药递释材料和诊疗药物制备领域的发展方向。未来,在微反应器内制备有机合成药物及中间体、纳米药物、载药递释材料和诊疗药物的技术将会朝着系统化、智能化、定制化、可持续化方向发展。
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齐亚兵
王康康
吴子波
党方方
关键词:  微反应器  微通道  制备  药物  中间体  载药递释材料  诊疗药物  影响因素    
Abstract: Compared to conventional reaction kettles, microreactors show unique advantages including better heat and mass transfer performances, more security, and precise controllability of reaction process. Therefore, microreactors can provide an efficient and convenient reaction platform for preparation of organic synthetic drugs and intermediates, nanodrugs, drug loading and releasing materials, and diagnostic and therapeutic drugs. The research progress on preparation of organic synthetic drugs and intermediates, nanodrugs, drug loading and releasing materials, and diagnostic and therapeutic drugs in microreactors are summarized. Then, the affecting factors of preparation of organic synthetic drugs and intermediates, nanodrugs, drug loading and releasing materials, and diagnostic and therapeutic drugs in microreactors are analyzed. Finally, the development trends of preparation of organic synthetic drugs and intermediates, nanodrugs, drug loading and releasing materials, and diagnostic and therapeutic drugs in microreactors are prospected. In the future, the preparation of organic synthetic drugs and intermediates, nanodrugs, drug loading and releasing materials, and diagnostic and therapeutic drugs in microreactor will develop towards systematization, intellectualization, customization and sustainability.
Key words:  microreactor    microchannel    preparation    drug    intermediate    drug loading and releasing material    diagnostic and therapeutic drug    affecting factor
出版日期:  2025-08-15      发布日期:  2025-08-15
ZTFLH:  TQ028.8  
  TQ052.5  
  R944.9  
基金资助: 西安市碑林区科技计划(GX2323);西安建筑科技大学人才科技基金(RC1714);西安建筑科技大学青年科技基金(QN1509)
通讯作者:  齐亚兵,西安建筑科技大学化学与化工学院讲师。目前主要从事传质与分离技术、微流控技术、水处理技术等研究工作。qiyabing123@163.com;吴子波,西南化工研究设计院有限公司主任工程师。目前主要从事风电醇氨、二氧化碳制甲醇、工业尾气高附加值利用(提氢、制醇、产LNG、合成氨)等相关碳一化工研究工作。155338531@qq.com   
引用本文:    
齐亚兵, 王康康, 吴子波, 党方方. 微反应器在药物、载药递释材料和诊疗药物制备领域应用的研究进展[J]. 材料导报, 2025, 39(16): 24070168-13.
QI Yabing, WANG Kangkang, WU Zibo, DANG Fangfang. Applicative Research Progress on Preparation of Drugs,Drug Loading and Releasing Materials,and Diagnostic and Therapeutic Drugs in Microreactors. Materials Reports, 2025, 39(16): 24070168-13.
链接本文:  
https://www.mater-rep.com/CN/10.11896/cldb.24070168  或          https://www.mater-rep.com/CN/Y2025/V39/I16/24070168
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