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材料导报  2019, Vol. 33 Issue (Z2): 538-541    
  高分子与聚合物基复合材料 |
层层自组装技术在组织工程领域的研究进展
郭雨晴, 张菁, 李颂
安徽医科大学,安徽医科大学口腔医学院,安徽医科大学附属口腔医院,安徽省口腔疾病研究中心实验室,合肥 230032
Research Progress of Layer-by-layer Self-assembly Technology in the Field of TissueEngineering
GUO Yuqing, ZHANG Jing, LI Song
Anhui Province Key Laboratory of Oral Diseases, the Affiliated Stomatological Hospital of Anhui Medical University, Research Stomatological College of Anhui Medical University, Anhui Medical University, Hefei 230032
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摘要 层层自组装(Layer-by-layer self-assembly,LBL)是利用逐层交替沉积的方法,借助各层分子间的弱相互作用,使层与层自发地缔合形成结构完整、性能稳定、具有某种特定功能的分子聚集体或超分子结构的过程。组织工程学被称为“再生医学”,是指利用生物活性物质,通过体外培养或构建的方法,再造或者修复器官及组织的技术,其主要包括新型生物材料、细胞来源、信号因子和生物制造方法等四个方面,目标是制造功能组织,用于再生医学和药物试验。本文就层层自组装技术在组织工程领域的研究进展进行综述。
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郭雨晴
张菁
李颂
关键词:  层层自组装(LBL)  组织工程  再生医学    
Abstract: Layer-by-layer self-assembly (LBL) is a method of layer by layer alternating deposition. According to the weak interactions between the layer of molecules, the layers spontaneously joined together to form a molecular aggregate or supramolecular structure which has a complete structure and stable performance. Tissue engineering is called "regenerative medicine", which refers to the technology of reconstructing or repairing organs and tissues by means of bioactive substances and in vitro culture or construction. It mainly includes four aspects: new biomaterials, cell sources, signal factors and biological manufacturing methods. The aim is to manufacture functional tissues for use in regenerative medicine and drug testing. In this paper, the research progress of layer-by-layer self-assembly in tissue engineering is reviewed.
Key words:  layer-by-layer self-assembly (LBL)    tissue engineering    regenerative medicine
               出版日期:  2019-11-25      发布日期:  2019-11-25
ZTFLH:  TB34  
基金资助: 国家自然科学基金(81400497)
通讯作者:  3197053337@qq.com   
作者简介:  郭雨晴,安徽医科大学口腔临床医学硕士研究生,本科毕业于安徽省皖南医学院。于2019年6月以第一作者身份在中文核心期刊上发表文章一篇。研究重点主要围绕骨组织再生,并且跟随研究生导师在临床上从事牙体牙髓专业方面的技能。
李颂,博士,教授。1994年获湖北医科大学硕士学位,2004年获华西医科大学口腔医学博士,2009年晋升教授职称,任硕士研究生导师。1994年至今于安徽医科大学口腔系从事教学、科研和临床工作。主要研究领域:儿童口腔变形链球菌的检出情况及和母亲的关系;儿童口腔变形链球菌的传播及影响因素;变链素产生的临床意义研究;变链素的纯化和序列测定、基因克隆;牙体牙髓病的临床研究。
引用本文:    
郭雨晴, 张菁, 李颂. 层层自组装技术在组织工程领域的研究进展[J]. 材料导报, 2019, 33(Z2): 538-541.
GUO Yuqing, ZHANG Jing, LI Song. Research Progress of Layer-by-layer Self-assembly Technology in the Field of TissueEngineering. Materials Reports, 2019, 33(Z2): 538-541.
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http://www.mater-rep.com/CN/  或          http://www.mater-rep.com/CN/Y2019/V33/IZ2/538
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