Fe-Mn合金在生物医学方面的应用及前景

材料导报

2019, Vol. 33

Issue (Z2): 331-335

金属与金属基复合材料

Fe-Mn合金在生物医学方面的应用及前景

刘玉玲¹, 张修庆²

1 华东理工大学材料科学与工程学院,上海 200237;
2 华东理工大学承压系统安全科学教育部重点实验室,上海 200237

Application and Prospect of Biomedical Fe-Mn Alloy

LIU Yuling¹, ZHANG Xiuqing²

1 School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237;
2 Key Laboratory of Pressure System Safety Science, Ministry of Education, East China University of Science and Technology, Shanghai 200237

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摘要生物可降解支架是在植入手术后血管修复期间为血管提供一定的支撑作用,然后预期在血管修复完成后一段时间内,通过与体内环境的相互作用转化成无毒性的降解产物被人体所吸收或排出体外。因此,人们对作为可降解支架的金属材料的力学性能、耐腐蚀性、降解特性、生物相容性等都提出了严格的要求。
近年来,铁基合金作为可降解金属材料成为生物医学领域新的研究热点。纯铁是人体必需的微量元素之一,且具有优异的力学特性、耐腐蚀性、降解特性、生物性能以及加工成型性,这使得铁基合金作为生物医用可降解材料成为可能。
然而,纯铁的降解速率过慢,这是阻碍其作为生物医用金属材料的主要问题之一。合金化在改善铁基材料降解性能的同时也可以改善力学性能,从而提高铁基材料的综合性能。在提高降解速率的同时,铁基材料也应保证足够的力学性能来支撑血管,并且力学性能越好、支架壁越薄、质量越小,则越能缩短降解时间,降解产物越少,对人体的毒性也越小。
本文综述了铁基合金作为支架材料的研究现状,以及目前报道的铁锰合金的力学性能、腐蚀降解性能以及体外细胞相容性,并重点介绍了铁锰合金在生物可降解支架方面的研究现状以及需解决的关键问题,同时给出可能的解决方案。

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	刘玉玲
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关键词: 生物医用Fe-Mn合金粉末冶金力学性能降解性能

Abstract: After the implantation operation, the biodegradable stent provides a certain supporting effect for the blood vessels during vasculars’ repairing, which is expected to convert into some non-toxic degradation products by interacting with the internal environment and then absorbed or excreted by the body within a certain time when the repairing is done. Therefore, to be degradable stents, strict requirements have been placed on the mechanical properties, corrosion resistance, degradation characteristics, biocompatibility, and other properities of metal materials.
In recent years, iron-based alloys, as degradable metal materials, have become a new research hotspot in biomedical field. Since pure iron is one of the essential trace elements in the human body, and excellent in mechanical properties, corrosion resistance, degradation characteristics, biological properties and processing formability, it is potential to be iron-based alloys as biomedical degradable materials.
However, pure iron has a slow degradation rate, which is one of the major problems that hinder its biomedical application. Alloying is expected to improve its degradation properties, mechanical properties, eventually as well as the overall performance of iron-based materials. While increa-sing degradation rate, iron-based materials should also be required to ensure adequate mechanical properties to support the blood vessels. And better mechanical properties, thinner stent as well as lighter mass, can ensure a shorter degradation time, which provides less degradation pro-ducts and toxic to the human body.
This paper reviews the research status of iron-based alloys as scaffold materials, as well as the mechanical properties, corrosion, degradation properties and in vitro cell compatibility of iron-manganese alloys. Meanwhile the present research status of ferromanganese alloys in biodegradable stents and key issues to be solved are mainly focused, as well as several potential solutions.

Key words: biomedical Fe-Mn alloy powder metallurgy mechanical properties degradation performance

出版日期: 2019-11-25 发布日期: 2019-11-25

ZTFLH:

R318.08

通讯作者: zhangxq@ecust.edu.cn

作者简介: 刘玉玲,2017年6月毕业于合肥学院,获得工学学士学位。现为华东理工大学材料科学与工程学院硕士研究生,在张修庆副教授的指导下进行研究。目前主要研究领域为生物可降解铁锰合金。
张修庆,华东理工大学副教授,硕士研究生导师。2006年博士研究生毕业于上海交通大学材料加工工程专业,毕业后到华东理工大学工作至今。其中2014.7—2015.2到美国伦斯勒理工学院进行访问、合作研究。在国内外学术期刊上发表论文60余篇,申请国家发明专利11项。其团队主要研究方向包括:表面工程技术,先进制造技术,材料的合成、结构与性能研究,新型合金材料、材料的腐蚀、磨损及防护,纳米材料制备、应用与工程,金属基复合材料的研制与开发等。负责完成科研项目10多项,已培养出硕士20余名。

引用本文:

刘玉玲, 张修庆. Fe-Mn合金在生物医学方面的应用及前景[J]. 材料导报, 2019, 33(Z2): 331-335.
LIU Yuling, ZHANG Xiuqing. Application and Prospect of Biomedical Fe-Mn Alloy. Materials Reports, 2019, 33(Z2): 331-335.

链接本文:

http://www.mater-rep.com/CN/ 或 http://www.mater-rep.com/CN/Y2019/V33/IZ2/331

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