Abstract: The present work proposed and successfully prepared a time-controlled/pH dependent colonic drug delivery system for berberine hydrochloride (BH), i.e. BH/MCM-41/CS-SA, by a combinative method of oscillation absorption and dip-coating, using MCM-41 mesoporous silica molecular sieve as the main body, BH drug molecules as the object, natural polymers — sodium alginate (SA) and chitosan (CS) as the coating materials. The physical and chemical properties of BH/MCM-41/CS-SA were characterized by XRD, SEM, BET and FTIR, and its drug loading and release properties in vitro were evaluated by spectrophotometry. The results showed that the drug loading rate of BH/MCM-41/CS-SA was 23.5%, and the mesoporous structure of MCM-41 was not destroyed after loading. In vitro results indicated the conspicuous time-delay/pH dependent drug release characteristic of BH/MCM-41/CS-SA compared with BH/MCM-41, which displays both favorable colon specific drug delivery performance and long-term controlled release efficacy.
毕玉水. 时间控制/pH依赖型盐酸黄连素结肠给药系统的控释性能[J]. 《材料导报》期刊社, 2018, 32(12): 1973-1977.
BI Yushui. Controlled Release Properties of a Time controlled/pH dependent Colonic Drug Delivery System for Berberine Hydrochloride. Materials Reports, 2018, 32(12): 1973-1977.
1 Luo A,Fan Y.Antioxidant activities of berberine hydrochloride[J].Journal of Medicinal Plants Research,2011,5(16):3702. 2 Yue H,Chang M,You Y,et al.Preparation of gastroretentive floa-ting tablets of berberine hydrochloride[J].Journal of Hebei University of Science and Technology,2011,32(1):69(in Chinese). 岳红坤,常明,游雅,等.盐酸小檗碱胃漂浮片的研制[J].河北科技大学学报,2011,32(1):69. 3 Zhu J X,Tang D,Feng L,et al.Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of ber-berine hydrochloride[J].Drug Development and Industrial Pharmacy,2013,39(3):499. 4 Ortiz L M G,Tillhon M,Parks M,et al.Multiple effects of berberine derivatives on colon cancer cells[J].BioMed Research International,2014,2014(2):924585. 5 Davis S S,Wilding E A,Wilding I R.Gastrointestinal transit of a matrix tablet formulation:Comparison of canine and human data[J].International Journal of Pharmaceutics,1993,94:235. 6 张阳德.纳米药物学[M].北京:化学工业出版社,2006:51. 7 Jiang Y,Liu Q.Preparation of alginate-starch blend microspheres for controlled release of berberine hydrochloride[J].Lishizhen Medicine and Materia Medica Research,2010,21(1):25(in Chinese). 江宇良,刘庆林.海藻酸钠/淀粉复合微球的制备及用于盐酸小檗碱的控制释放研究[J].时珍国医国药,2010,21(1):25. 8 Liu Y H,Zhu X,Zhou D,et al.pH-sensitive and mucoadhesive microspheres for duodenum-specific drug delivery system[J].Drug Deve-lopment and Industrial Pharmacy,2011,37(7):868. 9 Vallet-regi M,Rámila A,Del Real R P,et al.A new property of MCM-41:Drug delivery system[J].Chemistry of Materials,2001,13(2):308. 10 Wu Y,Liu X,Wang Y,et al.Review on preparation of sodium alginate nanoparticles[J].Materials Review A: Review Papers,2016,30(3):7(in Chinese). 吴叶,刘袖洞,王云红,等.海藻酸钠纳米粒制备的研究进展[J].材料导报:综述篇,2016,30(3):7. 11 He B,Zhang B,Li S,et al.Preparation of 5-fluorouracil loaded chitosan/gelatin particles and its’ drug release properties[J].Chemical Industry and Engineering Progress,2016,35(7):2151(in Chinese). 贺宝元,张宝艳,李珊,等.载5-氟尿嘧啶壳聚糖/明胶微粒的制备及药物释放性能[J].化工进展,2016,35(7):2151. 12 Li C,Nie H,Li J,et al.Study on preparation and release characteristics of pectin matrix tablets modified by mechanical activation[J].Materials Review,2016,30(S1):304(in Chinese). 李辰,聂卉,李坚斌,等.机械活化改性果胶骨架片的制备及释放特性研究[J].材料导报,2016,30(S1):304. 13 Li X,Zhang H,Huang X,et al.Preparation of berberine hydrochloride-loaded gelatin nanoparticles[J].Northwest Pharmaceutical Journal,2015,30(4):393(in Chinese). 李小第,张海龙,黄小艳,等.盐酸小檗碱明胶纳米粒的制备[J].西北药学杂志,2015,30(4):393. 14 Mihai G D,Meynen V,Mertens M,et al.ZnO nanoparticles supported on mesoporous MCM-41 and SBA-15:A comparative physicochemical and photocatalytic study[J].Journal of Materials Science,2010,45:5786. 15 Hu Y,Zhi Z,Zhao Q,et al.3D cubic mesoporous silica microsphere as a carrier for poorly soluble drug carvedilol[J].Microporous and Mesoporous Materials,2012,147:94. 16 Zhang Z,Zhang P,Zhang W,et al.Preparation and characterization of berberine hydrochloride ternary complexes[J].World Science and Technology/Modernization of Traditional Chinese Medicine and Materia Medica,2014,16(10):2208(in Chinese). 张中义,张攀攀,张文杰,等.盐酸小檗碱脱苦三元复合物的制备及其表征[J].世界科学技术—中医药现代化,2014,16(10):2208. 17 Wu Y,Xiao X,Sun S,et al.Study on traditional chinese medicine extracts of rhizoma coptidis by FTIR spectroscopy[J].Spectroscopy and Spectral Analysis,2009,29(1):93(in Chinese). 武彦文,肖小河,孙素琴,等.黄连不同提取物的红外光谱研究[J].光谱学与光谱分析,2009,29(1):93. 18 Balaure P C,Andronescu E,Grumezescu A M,et al.Fabrication,characterization and in vitro profile based interaction with eukaryotic and prokaryotic cells of alginate-chitosan-silica biocomposite[J].International Journal of Pharmaceutics,2013,441:555. 19 George M,Abraham T E.Polyionic hydrocolloids for the intestinal delivery of protein drugs:Alginate and chitosan—A review[J].Journal of Controlled Release,2006,114:1. 20 Nagarwal R C,Kumar R,Pandit J K.Chitosan coated sodium alginate-chitosan nanoparticles loaded with 5-FU for ocular delivery:In vitro characterization and in vivo study in rabbit eye[J].European Journal of Pharmaceutical Sciences,2012,47:678.
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2018, Vol. 32 
