骨组织工程镁基支架的制备研究进展

doi:10.11896/cldb.22050324

材料导报

2024, Vol. 38

Issue (4): 22050324-11 https://doi.org/10.11896/cldb.22050324

金属与金属基复合材料

骨组织工程镁基支架的制备研究进展

李再久^1,2,*, 夏臣平¹, 刘明诏², 金青林²

1 昆明理工大学民航与航空学院,昆明 650500
2 昆明理工大学材料科学与工程学院,昆明 650093

Research Progress of Preparation of Magnesium-based Scaffolds for Bone Tissue Engineering

LI Zaijiu^1,2,*, XIA Chenping¹, LIU Mingzhao², JIN Qinglin²

1 Faculty of Civil Aviation and Aeronautics, Kunming University of Science and Technology, Kunming 650500, China
2 Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China

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摘要骨组织工程为受损骨、病变骨的治疗提供了重要的途径。如何获得易于骨修复、高强度且具有良好生物相容性的支架,是当前骨组织工程支架应用的技术难点和研究热点之一。支架材料的种类及制备方法是影响骨组织工程结构及性能的主要因素。镁基合金因在生物相容性、降解行为等方面具有突出表现而受到了普遍的关注,被认为是一种前景广阔的骨组织工程支架材料。常见的骨组织工程镁基支架制备方法有熔体发泡法、渗流铸造法、固/气共晶定向凝固法和增材制造法等,然而现有制备方法在孔隙结构精细控制及造孔残留物对镁基支架生物相容性的影响等方面仍需进一步研究。本文综述了骨组织工程镁基支架的制备方法,分析了影响镁基支架孔隙结构和性能的因素,总结了每种制备方法的优缺点,并对未来的研究方向进行了展望。

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	李再久
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关键词: 骨组织工程镁基支架制备方法孔隙结构

Abstract: Bone tissue engineering provides an important approach for the treatment of damaged bone and diseased bone. Recently, the research on fabricating scaffolds with bone reconstruction, high strength, and good biocompatibility, has been one of the most popular topics and technical difficulties in the application of bone tissue engineering scaffolds. The types and preparation methods of scaffold material are major factors affecting its structure and properties. Magnesium-based alloys have attracted widespread attention because of its outstanding performance in biocompatibility and degradation behavior, and have been considered as a candidate class of promising scaffold materials for bone tissue enginee-ring. The preparation methods of magnesium-based scaffolds for bone tissue engineering include melt foaming, infiltration casting, solid/gas eutectic directional solidification and additive manufacturing, etc. However, the existing preparation methods still need to be further studied in the aspects of fine control of pore structure and the effect of pore-making residues on the biocompatibility of magnesium-based scaffolders. This article reviews the preparation methods of magnesium-based scaffolds used in bone tissue engineering, analyzes the main factors affecting pore structure and properties of scaffolds, summarizes the advantages and disadvantages of each preparation method, and discusses the trends of future research.

Key words: bone tissue engineering magnesium-based scaffold preparation method pore structure

出版日期: 2024-02-25 发布日期: 2024-03-01

ZTFLH:

TG146

基金资助: 国家自然科学基金(51864026);云南省重大专项计划(202202AG050011)

通讯作者: *李再久,昆明理工大学民航与航空学院副教授、硕士研究生导师。2006年7月本科毕业于重庆大学材料科学与工程学院,2014年6月在昆明理工大学材料加工工程专业取得博士学位,2014年7月至2017年7月在昆明贵金属研究所工作,2017年8月至今在昆明理工大学民航与航空学院工作。目前主要从事定向凝固规则多孔材料及其应用研究工作。主持国家自然科学基金、云南省重大专项计划等科研项目。获国内外发明专利5项,发表研究论文40余篇,包括Crystal Growth & Design、Vacuum、Materials Letters、JOM、《金属学报》等。lizaijiu@126.com

引用本文:

李再久, 夏臣平, 刘明诏, 金青林. 骨组织工程镁基支架的制备研究进展[J]. 材料导报, 2024, 38(4): 22050324-11.
LI Zaijiu, XIA Chenping, LIU Mingzhao, JIN Qinglin. Research Progress of Preparation of Magnesium-based Scaffolds for Bone Tissue Engineering. Materials Reports, 2024, 38(4): 22050324-11.

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http://www.mater-rep.com/CN/10.11896/cldb.22050324 或 http://www.mater-rep.com/CN/Y2024/V38/I4/22050324

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