用于肺癌早期筛查的Zn2SnO4/rGO气凝胶的正丁醇微量检测研究

doi:10.11896/cldb.25030079

材料导报

2026, Vol. 40

Issue (7): 25030079-7 https://doi.org/10.11896/cldb.25030079

无机非金属及其复合材料

用于肺癌早期筛查的Zn₂SnO₄/rGO气凝胶的正丁醇微量检测研究

朱凯¹, 严文倩^2,3,*, 刘伟⁴, 沈晓冬⁴

1 上海交通大学医学院附属同仁医院,上海 200336
2 三棵树(上海)新材料研究有限公司,上海 201100
3 福建省建筑涂料企业重点实验室,福建莆田 351100
4 南京工业大学材料科学与工程学院,南京 211800

Study on the n-Butanol Micro-detection Using Zn₂SnO₄/rGO Aerogel for Early Screening of Lung Cancer

ZHU Kai¹, YAN Wenqian^2,3,*, LIU Wei⁴, SHEN Xiaodong⁴

1 Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
2 Skshu New Materials Research (Shanghai) Co., Ltd., Shanghai 201100, China
3 Fujian Key Laboratory of Architectural Coating, Putian 351100, Fujian, China
4 School of Materials Science and Engineering, Nanjing Tech University, Nanjing 211800, China

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摘要 Zn₂SnO₄由ZnO与SnO₂通过热处理反应生成,属于双金属氧化物固溶体,具备优异的气体传感性能。采用水热法合成Zn₂SnO₄后,将其与石墨烯气凝胶复合,为避免二次水热破坏物相,借助吡咯单体受热聚合的原理促进氧化石墨烯自组装,再经置换、冷冻干燥得到Zn₂SnO₄/石墨烯气凝胶。该材料具有良好的吸附性能,在130 ℃下对浓度为10^-5的正丁醇气体的响应值可达4.0,理论检测限低至4.7×10^-9,符合气体传感器的高精度要求。此外,正丁醇是肺癌患者呼出物的组成之一,针对Zn₂SnO₄/石墨烯气凝胶气敏材料的研究,可用于早期肺癌的初步筛查和疾病诊断,拓宽了气体传感器在医学领域的应用。

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关键词: Zn₂SnO₄ 石墨烯气凝胶异质结气体传感正丁醇肺癌筛查

Abstract: Zn₂SnO₄ was synthesized through a solid-state reaction between ZnO and SnO₂ under thermal treatment, forming a bimetallic oxide solid solution with exceptional gas sensing performance. In this study, Zn₂SnO₄ was initially synthesized via a hydrothermal method and subsequently combined with graphene aerogel. To circumvent phase degradation during secondary hydrothermal processing, pyrrole monomer polymerization under thermal activation was leveraged to promote the self-assembly of graphene oxide. The composite material was then obtained through displacement processing and freeze-drying, yielding Zn₂SnO₄/graphene aerogel. This material exhibits superior adsorption properties, demonstrating a response value of 4.0 at 130 ℃ for 10^-5 n-butanol vapor, with a theoretical detection limit as low as 4.7×10^-9, meeting stringent requirements for high-precision gas sensing. Notably, n-butanol is a component of exhaled breath in lung cancer patients. The development of Zn₂SnO₄/graphene aerogel-based gas-sensitive materials holds potential for preliminary screening and diagnosis of early-stage lung cancer, thereby expanding the medical applications of gas sensors.

Key words: Zn₂SnO₄ graphene aerogel heterojunction gas sensitivity n-butanol lung cancer screening

发布日期: 2026-04-16

ZTFLH:

TP212.2

通讯作者: *严文倩,博士,研究方向为基于金属氧化物半导体的气敏气凝胶。wqyan1996@njtech.edu.cn

作者简介: 朱凯,硕士,主要从事生物医用气体传感方面的研究。

引用本文:

朱凯, 严文倩, 刘伟, 沈晓冬. 用于肺癌早期筛查的Zn₂SnO₄/rGO气凝胶的正丁醇微量检测研究[J]. 材料导报, 2026, 40(7): 25030079-7.
ZHU Kai, YAN Wenqian, LIU Wei, SHEN Xiaodong. Study on the n-Butanol Micro-detection Using Zn₂SnO₄/rGO Aerogel for Early Screening of Lung Cancer. Materials Reports, 2026, 40(7): 25030079-7.

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https://www.mater-rep.com/CN/10.11896/cldb.25030079 或 https://www.mater-rep.com/CN/Y2026/V40/I7/25030079

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