石墨烯纳米复合材料在电化学核酸传感器中的应用

doi:10.11896/cldb.23070077

材料导报

2024, Vol. 38

Issue (24): 23070077-7 https://doi.org/10.11896/cldb.23070077

无机非金属及其复合材料

石墨烯纳米复合材料在电化学核酸传感器中的应用

李亚婷, 刘仲明, 陈钰, 郭彦彤, 杨欢, 张海燕^*

中国人民解放军南部战区总医院,广州 510010

Applications of Graphene Nanocomposites in Electrochemical Nucleic Acid Sensors

LI Yating, LIU Zhongming, CHEN Yu, GUO Yantong, YANG Huan, ZHANG Haiyan^*

General Hospital of Southern Theatre Command, Guangzhou 510010, China

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摘要近年来,各个领域对核酸检测的需求逐渐增加,具有高灵敏度和特异性的核酸分子检测设备的研发也成为当下的研究热点。其中,电化学检测设备具有响应快速、操作简单、携带方便、制作成本低等优势。而对于电化学传感器的研发,其中最重要的部分就是电极材料的选择,石墨烯及其衍生物不仅具有优异的电学、力学和电化学性质,还能够与金属纳米颗粒、金属氧化物、金属有机框架、聚合物和离子液体等形成纳米复合材料。基于这些纳米复合材料的电化学传感器已经在核酸检测中发挥了重要的作用。在此,首先介绍了石墨烯及其衍生物的独特结构特性,之后基于不同石墨烯纳米复合材料对石墨烯电化学传感进行了分类,最后探讨了电化学传感器用于核酸检测的场景,并对石墨烯电化学传感器的发展前景进行了讨论和展望。

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关键词: 石墨烯石墨烯氧化物电化学传感器核酸纳米材料

Abstract: In recent years, the demand for nucleic acid detection is gradually increased in various fields, and the development of nucleic acid molecular detection devices with high sensitivity and specificity has become a hot research nowadays. Among these studies, electrochemical detection devices have the advantages of fast response, simple operation, portability, and low production cost. For the development of electrochemical sensors, one of the most important parts is the selection of electrode materials. Graphene and its derivatives not only have excellent electrical, mechanical, and electrochemical properties, but are also capable of forming nanocomposites with metal nanoparticles, metal oxides, metal organic frameworks, polymers, and ionic liquids. Electrochemical sensors based on these nanocomposites have already played an important role in the detection of nucleic acids. Here, the unique structural properties of graphene and its derivatives are first introduced, followed by a classification of graphene electrochemical sensing based on different graphene nanocomposites, and finally the application scenarios of electrochemical sensors for nucleic acid detection are explored, and the prospects for the development of graphene electrochemical sensors are discussed and looked into.

Key words: graphene graphene oxide electrochemical biosensor nucleic acid nanomaterial

出版日期: 2024-12-25 发布日期: 2024-12-20

ZTFLH:

Q819

通讯作者: * 张海燕,广州中医药大学南部战区总医院硕士研究生导师、副主任技师,2002年毕业于广州师范大学,2005年毕业于第一军医大学,2008年毕业于南方医科大学。目前主要从事核酸快速检测、基因芯片在临床疾病诊断中的应用的研究工作,发表论文68篇。曾获国家质量监督检验检疫总局“科技兴检奖”二等奖。获多项国家发明和实用新型专利。 zhanghaiyan1998@126.com

作者简介: 李亚婷,2020年7月于锦州医科大学获得理学学位,现为广州中医药大学南部战区总医院临床检验诊断学硕士研究生,在导师张海燕的指导下进行研究,目前主要研究领域为生物传感。

引用本文:

李亚婷, 刘仲明, 陈钰, 郭彦彤, 杨欢, 张海燕. 石墨烯纳米复合材料在电化学核酸传感器中的应用[J]. 材料导报, 2024, 38(24): 23070077-7.
LI Yating, LIU Zhongming, CHEN Yu, GUO Yantong, YANG Huan, ZHANG Haiyan. Applications of Graphene Nanocomposites in Electrochemical Nucleic Acid Sensors. Materials Reports, 2024, 38(24): 23070077-7.

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http://www.mater-rep.com/CN/10.11896/cldb.23070077 或 http://www.mater-rep.com/CN/Y2024/V38/I24/23070077

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