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材料导报  2021, Vol. 35 Issue (1): 1096-1104    https://doi.org/10.11896/cldb.20050019
  无机非金属及其复合材料 |
生物陶瓷支架促进再生组织血管生成和骨生成的研究进展
樊光娆, 苏海军, 郭敏, 张军, 高嘉亮, 郝宣成, 宋强, 刘林, 傅恒志
西北工业大学凝固国家重点实验室,西安 710072
Research Progress on Bioceramics Scaffolds in Promoting Angiogenesis and Osteogenesis in Regenerated Tissues
FAN Guangrao, SU Haijun, GUO Min, ZHANG Jun, GAO Jialiang, HAO Xuancheng, SONG Qiang, LIU Lin, FU Hengzhi
State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi'an 710072, China
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摘要 近年来,组织工程作为一种有前景的治疗和修复骨缺损的方法受到了广泛的关注。支架是组织工程的基本组成部分,它能够为骨组织再生提供必要的支撑和导向作用。骨组织修复过程中需要在支架内部形成一个血管网络来为细胞迁移、增殖和分化提供营养和氧气,从而实现组织再生。因此,组织工程血管化是实现骨组织再生的首要前提。生物陶瓷凭借其特殊的化学成分、高的压缩强度和优异的生物活性,成为骨再生支架的有力候选材料。
   然而,生物陶瓷支架在植入体内后,往往需要较长的时间才能形成血管网络。这就意味着组织内部的细胞会因长时间缺乏营养而死亡,影响组织再生效果。因此,近些年来,除研究材料成分对再生组织的血管生成和骨生成效果的影响外,研究者还从支架结构设计和支架外部的环境因素着手,以进一步提高生物陶瓷支架诱导血管生成和骨生成的能力。
   生物复合陶瓷不仅能提高支架的力学性能,还能改善支架的生物活性。分级多孔设计可以模拟自然骨的结构,从而更好地促进再生组织的血管化和骨生成。加载生长因子、元素掺杂和细胞植入可以为血管化提供更好的外部环境,从而更好地实现组织再生。这些因素可以协同发挥作用来促进生物陶瓷支架的血管生成和骨生成。
   本文从三个方面总结了影响生物陶瓷支架促进再生组织血管生成和骨生成的因素——支架材料、支架结构和支架所处的环境,并系统分析了以上因素的影响机理。最后,展望了生物陶瓷支架的发展趋势,以期为生物陶瓷的设计、加工和生物工程应用提供参考。
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樊光娆
苏海军
郭敏
张军
高嘉亮
郝宣成
宋强
刘林
傅恒志
关键词:  生物陶瓷支架  组织工程  血管生成  骨生成    
Abstract: Tissue engineering has acquired remarkable attention as a promising strategy to treat and restore bone defects during recent years. A scaffold is a fundamental component for tissue engineering, which provides a necessary support and guidance for bone tissue regeneration. It is necessary to form a vascular network inside the scaffold to provide nutrients and oxygen for cells to migrate, proliferate and differentiate, and then realize tissue regeneration in the process of bone tissue repair. Consequently, the vascularization is the first requirement to achieve bone tissue regeneration. Bioceramics have become competetive candidates as scaffold materials for bone tissue regeneration due to the special chemical composition, high compressive strength and excellent bioactivity.
However, a vascular networks formed in the bioceramic scaffolds will take a long time after implantation in vivo, meaning that cells in the middle of the tissue will be straved of nutrients for a long time and then die. This urges intensive research works to study the effect of material, structure and environmental factors of the bioceramic scaffolds on the osteogenesis and vasculature, aiming at achieving better tissue regeneration.
The composites can not only improve the mechanical properties of the scaffold, but also improve the biological activity of the scaffold. Designing hierarchical porous structure and loading growth factors can better stimulate angiogenesis and osteogenesis of the regenerated tissue. These aspects can be considered in combination to promote the angiogenesis and osteogenesis of the bioceramic scaffolds.
This review summarizes the factors affecting angiogenesis and osteogenesis of regenerated tissues in the bioceramic scaffolds from three aspects: scaffold material, scaffold structure and environmental factors of the scaffold. Meanwhile, the influence mechanisms of the above factors are systematically analyzed. Finally, the development trend of the bioceramic scaffolds is prospected expecting to provide references for the design, processing and bioengineering applications of the bioceramics.
Key words:  bioceramic scaffolds    tissue engineering    angiogenesis    osteogenesis
               出版日期:  2021-01-10      发布日期:  2021-01-19
ZTFLH:  TQ174  
基金资助: 国家重点基础研究发展计划项目(2017YFB1103500; 2018YFB1106600);国家自然科学基金委优青项目(51822405);陕西省重点研发计划项目(2018ZDCXL-GY-09-04);凝固技术国家重点实验室自主课题(2019-QZ-02)
作者简介:  樊光娆,2015年6月毕业于太原理工大学,获得工学学士学位。现为西北工业大学凝固国家重点实验室博士研究生,在张军教授和苏海军教授的指导下进行研究。目前主要研究领域为定向凝固共晶生物陶瓷。
苏海军,西北工业大学材料学院教授,博士研究生导师。国家自然科学基金优秀青年基金获得者,入选国家首批“香江学者”计划,陕西省“青年科技新星”,陕西高校青年创新团队学术带头人。主要从事先进生物复合陶瓷设计、制备及应用研究,主持包括国家自然科学基金4项等在内的国家及省部级科研项目20余项,研究成果在Small、ACS Applied Materials and Interfaces、Journal of the European Ceramic Society等国际著名学术期刊上发表SCI论文100余篇。获授权中国发明专利26项以及1项美国发明专利。参编专著3部。获陕西省科学技术一等奖和陕西省青年科技奖各1项。
引用本文:    
樊光娆, 苏海军, 郭敏, 张军, 高嘉亮, 郝宣成, 宋强, 刘林, 傅恒志. 生物陶瓷支架促进再生组织血管生成和骨生成的研究进展[J]. 材料导报, 2021, 35(1): 1096-1104.
FAN Guangrao, SU Haijun, GUO Min, ZHANG Jun, GAO Jialiang, HAO Xuancheng, SONG Qiang, LIU Lin, FU Hengzhi. Research Progress on Bioceramics Scaffolds in Promoting Angiogenesis and Osteogenesis in Regenerated Tissues. Materials Reports, 2021, 35(1): 1096-1104.
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http://www.mater-rep.com/CN/10.11896/cldb.20050019  或          http://www.mater-rep.com/CN/Y2021/V35/I1/1096
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