Abstract: Photothermal therapy (PTT) combined with chemotherapy has become a promising strategy for breast cancer treatment by precisely controlling drug release, reducing multidrug resistance and improving therapeutic efficacy. To this end, we designed and prepared a metal-organic coordination nano-delivery system FA-PEG/Qu-Fe(II)-PDA (FA@QFD NPs) based on the small molecule antitumor drug quercetin for tumor targeting chemistry/photothermal synergistic therapy. First, QFD NPs were synthesized from quercetin, dopamine hydrochloride and ferrous ion by ‘one-pot’ method, and then targeted modification with FA-PEG-NH2 was carried out to obtain FA@QFD NPs. The coordination system achieves the drug loading of quercetin as high as 31.61% and the drug encapsulation efficiency of 95.1%, which effectively improves the defects of poor water solubility and low drug utilization rate of quercetin. The nano system exhibits good stability under normal physiological environment, and can target tumor cells through folic acid, which leads to the cleavage of coordination bonds under the action of low pH value and abundant hydrogen peroxide in the tumor microenvironment, releasing quercetin for chemotherapy, and further killing tumor cells can be enhanced under infrared irradiation and photothermal effect generated by polydopamine (PDA). When FA@QFD NPs were incubated with 4T1 cells, the average survival rate of cancer cells under 808 nm laser irradiation was only 14.73%, which was much lower than the 62.48% in the monotherapy group. This work not only designs a highly efficient anticancer nanoparticle for chemical/photothermal synergistic therapy, but also provides a new idea for the loading of those poorly water-soluble polyphenols.
1 Lei W, Sun C S, Jiang T Y, et al. Materials Science & Engineering C-materials for Biological Applications, 2019, 105, 110103. 2 Li J, Zhang C T, Gong S M, et al. Acta Biomaterialia, 2019, 94, 435. 3 Zhang Y, Wang L, Liu L, et al. ACS Applied Materials & Interfaces, 2018, 10, 41035. 4 Wei J, Zhang H Y, Wu J L, et al. ACS Applied Materials & Interfaces, 2018, 10, 34513. 5 Kemp J A, Shim M S, Heo C Y, et al. Advanced Drug Delivery Reviews, 2016, 98, 3. 6 Fan R R, Chen C L, Hou H, et al. Advanced Functional Materials, 2021, 31(18), 2009733. 7 Cheng L, Wang C, Feng L Z, et al. Chemical Reviews, 2014, 114(21), 10869. 8 Atila Dincer C, Getiren B, Gokalp C, et al. Colloids and Surfaces A-physicochemical And Engineering Aspects, 2022, 633, 127791. 9 Hosseini V, Mirrahimi M, Shakeri-Zadeh A, et al. Photodiagnosis and Photodynamic Therapy, 2018, 24, 129. 10 Dai X G, Zhao X Y, Liu Y J, et al. Small, 2021, 17(11), 2006004. 11 Liu J J, Liu K, Feng L Z, et al. Biomaterials Science, 2017, 5(2), 331. 12 Fan X, Yuan Z T, Shou C T, et al. International Journal of Nanomedicine, 2019, 14, 9631. 13 Li H M, Yin D, Li W, et al. Colloids and Surfaces B-Biointerfaces, 2021, 199, 111502. 14 El Yakhlifi S, Ball V. Colloids and Surfaces B-Biointerfaces, 2020, 186, 110719. 15 Xiong Q, Wang Y W, Wan J Y, et al. International Journal of Biological Macromolecules, 2020, 147, 937. 16 Tian F C, Dahmani F Z, Qiao J N, et al. Acta Biomaterialia, 2018, 75, 398. 17 Wang R E, Kao J L F, Hilliard C A, et al. Journal of Medicinal Chemistry, 2009, 52(7), 1912. 18 Abd-Rabou A A, Ahmed H H. Advances in Medical Sciences, 2017, 62(2), 357. 19 Fang J, Zhang S W, Xue X F, et al. International Journal of Nanomedicine, 2018, 13, 5113. 20 Zhou X, Liu H Y, Zhao H, et al. Oncotargets and Therapy, 2018, 11, 5397. 21 Li J, Zhu J X, Wu H, et al. Journal of Molecular Liquids, 2022, 349, 118164. 22 Singh N, Sallem F, Mirjolet C, et al. Nanomaterials, 2019, 9(2), 138. 23 Chen G J, Ben M, Wang Y Y, et al. ACS Applied Materials & Interfaces, 2017, 9, 41700.
渝公网安备50019002502923号 版权所有：《材料导报》编辑部
2023, Vol. 37 
