光固化3D打印磷酸钙基生物陶瓷支架的研究进展

doi:10.11896/cldb.22010288

材料导报

2023, Vol. 37

Issue (18): 22010288-9 https://doi.org/10.11896/cldb.22010288

无机非金属及其复合材料

光固化3D打印磷酸钙基生物陶瓷支架的研究进展

董栋¹, 苏海军^1,2,*, 李翔², 赵迪², 樊光娆², 申仲琳^1,2, 刘园²

1 西北工业大学深圳研究院,广东深圳 518057
2 西北工业大学凝固技术国家重点实验室,西安 710072

Research Progress on Preparation of Calcium Phosphates Bioceramic Scaffolds by Vat Polymerization 3D Printing

DONG Dong¹, SU Haijun^1,2,*, LI Xiang², ZHAO Di², FAN Guangrao², SHEN Zhonglin^1,2, LIU Yuan²

1 Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, Guangdong, China
2 State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi'an 710072, China

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摘要磷酸钙基生物陶瓷多孔支架是临床中实现骨缺损再生修复的常用骨移植物。光固化3D打印技术以其优异的打印精度和复杂结构成形特性能够精确地控制支架孔尺寸、孔形状、孔连通率,在制备生物陶瓷多孔支架领域展现出巨大的应用潜力。然而,利用光固化3D打印技术制备磷酸钙基生物陶瓷多孔支架仍面临亟需克服的挑战,如缺乏性能优异的磷酸钙基陶瓷打印浆料、打印及后处理工艺不成熟、制备的磷酸钙基陶瓷多孔支架的性能还有待提升。本文首先介绍了几种常用的光固化3D打印技术基本原理与特征,然后从3D打印成形工艺、力学性能、生物活性、支架结构及功能化等方面系统探讨了光固化3D打印技术在制备磷酸钙基生物陶瓷多孔支架领域的研究进展及存在的问题,最后展望了光固化3D打印磷酸钙基生物陶瓷多孔支架的发展趋势和突破点,为利用光固化3D打印技术制备成本低、综合性能优异的磷酸钙基生物陶瓷多孔支架提供参考。

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	刘园

关键词: 光固化3D打印生物陶瓷多孔支架骨缺损磷酸钙

Abstract: Calcium phosphate bioceramic porous scaffolds are commonly used as bone grafts for regenerative repair of bone defects in clinic. Vat polymerization (VP-based) 3D printing techniques are capable of precisely controlling the pore size, pore shape, interconnectivity of scaffold by its excellent printing accuracy and ability of complex structure forming. Therefore, VP-based 3D printing techniques have shown great prospects in the field of fabricating bioceramic porous scaffolds for regenerative repair of bone defects. However, the VP-based 3D printing of calcium phosphate bioceramic porous scaffolds still faces several prickly issues. For example, there is lack of high loading calcium phosphate ceramic slurry with low viscosity and low refractive index difference, and the printing and post-processing processes are immature, and the performance of calcium phosphate ceramic scaffolds needs to be improved. This review briefly introduces the basic principles and characteristics of several commonly used VP-based 3D printing technologies at first, and then systemically explores the research progress and existing problems of VP-based 3D printing techniques in the preparation of calcium phosphate bioceramic porous scaffolds from the aspects of 3D printing forming process, mechanical properties, biological activity, scaffold structure and functionalization. Finally, the development trend and breakthrough points of VP-based 3D printing calcium phosphate bioceramic scaffolds are prospected, in order to provide a new way for the preparation of calcium phosphate bioceramic scaffolds with excellent comprehensive properties and low cost by VP-based 3D printing technologies.

Key words: VP-based 3D printing bioceramic porous scaffold bone defect calcium phosphate

出版日期: 2023-09-25 发布日期: 2023-09-18

ZTFLH:

TB34

基金资助: 广东省基础与应用基础研究基金重点项目(2021B1515120028);国家自然科学基金(52130204;52174376);陕西省科技创新团队计划项目(2021TD-17);中央高校基础研究基金(D5000210902);西北工业大学博士论文创新基金(CX2021056;CX2021066)

通讯作者: *苏海军,西北工业大学材料学院教授、博士研究生导师。国家自然科学基金优秀青年基金获得者,入选国家首批“香江学者”计划,陕西省“青年科技新星”,陕西省重点科技创新团队和高校青年创新团队学术带头人。主要从事先进复合陶瓷设计、制备及应用研究,主持包括国家自然科学基金重点项目等六项国家基金在内的国家及省部级科研项目30余项,研究成果在Nano Letters、Small、ACS Applied Materials and Interfaces、Journal of the European Ceramic Society等国际著名学术期刊上发表SCI论文150余篇。获授权中国发明专利50余项以及一项美国发明专利。参编专著三部。获陕西高校优秀研究成果特等奖、陕西省科学技术一等奖、全国有色金属优秀青年科技奖和陕西省青年科技奖各一项。shjnpu@nwpu.edu.cn

作者简介: 董栋,2015年6月、2020年3月分别于东北石油大学和西北工业大学取得工学学士和硕士学位。现为西北工业大学材料学院博士研究生,在苏海军教授的指导下进行研究。目前主要研究领域为光固化3D打印制备生物活性陶瓷。

引用本文:

董栋, 苏海军, 李翔, 赵迪, 樊光娆, 申仲琳, 刘园. 光固化3D打印磷酸钙基生物陶瓷支架的研究进展[J]. 材料导报, 2023, 37(18): 22010288-9.
DONG Dong, SU Haijun, LI Xiang, ZHAO Di, FAN Guangrao, SHEN Zhonglin, LIU Yuan. Research Progress on Preparation of Calcium Phosphates Bioceramic Scaffolds by Vat Polymerization 3D Printing. Materials Reports, 2023, 37(18): 22010288-9.

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http://www.mater-rep.com/CN/10.11896/cldb.22010288 或 http://www.mater-rep.com/CN/Y2023/V37/I18/22010288

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