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材料导报  2025, Vol. 39 Issue (24): 25040080-8    https://doi.org/10.11896/cldb.25040080
  高分子与聚合物基复合材料 |
铜掺杂生物活性玻璃/壳聚糖季铵盐复合水凝胶的构建及多网络协同增强机制
张芮1,2, 马晓丽1,2, 仝凤莲1,2,*
1 新疆医科大学药学院,乌鲁木齐 830054
2 新疆天然药物活性成分与药物释放技术重点实验室,乌鲁木齐 830054
Construction of Copper-doped Bioactive Glass/Quaternized Chitosan Composite Hydrogels and Their Multi-network Synergistic Enhancement Mechanism
ZHANG Rui1,2, MA Xiaoli1,2, TONG Fenglian1,2,*
1 College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China
2 Key Laboratory of Active Ingredients and Drug Release Technology for Natural Medicines in Xinjiang, Urumqi 830054, China
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摘要 皮肤修复领域科研人员近期关注生物活性玻璃(BGs)与壳聚糖季铵盐(QCS)水凝胶协同作用。针对BGs单体易致组织损伤及纯QCS力学性能不足的问题,本工作开发了一种通过将掺铜生物活性玻璃(Cu-BGs)与QCS协同集成的多网络水凝胶系统。采用溶胶-凝胶法结合模板诱导技术制备铜掺杂BGs(Cu-BGs),并通过冻融循环法构建聚乙烯醇(PVA)/QCS/Cu-BGs(PQB-Cu)多网络水凝胶。实验表明:4%(质量分数)掺杂时Cu-BGs呈球形形貌,实现了Cu的均匀负载,XRD和BET证实其具有介孔特征的无定形结构。PQB-0.5%Cu水凝胶通过静电相互作用与动态硼酸酯键形成三维网络,SEM呈现贯通的多孔结构;材料的自愈合性能可实现无痛换药;粘附强度为(13.98±1.77) kPa,高于商业敷料Greenplast的5 kPa,溶胀率高达300%,断裂伸长率为(316.10±41.10)%,远超人体皮肤需求的17%～27%。体外离子释放实验中,PQB-0.5%Cu展现出“初期快速释放+后期缓慢释放”的Cu离子可控释放能力。Cu-BGs与QCS复合水凝胶协同促进人脐静脉内皮细胞(HUVECs)迁移,24 h划痕愈合率提升1.26倍。本工作制备的PQB-Cu多网络水凝胶具有较好的力学性能,能促进细胞迁移,为开发具有优异力学性能和促进创面愈合功能的创面敷料提供了创新方案。
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张芮
马晓丽
仝凤莲
关键词:  生物活性玻璃  水凝胶  多网络  铜离子    
Abstract: In recent years, researchers in the field of skin wound healing have focused on the synergistic interaction between bioactive glass (BGs) and chitosan quaternary ammonium salt (QCS)-based hydrogels. Conventional BGs monomers often induce tissue irritation, while QCS hydrogels exhibit inadequate mechanical strength. To address these limitations, a multi-network hydrogel system by synergistically integrating copper-doped bioactive glasses (Cu-BGs) with QCS was developed in this work. Cu-BGs was synthesized using a sol-gel method coupled with a templating strategy. Subsequently, polyvinyl alcohol (PVA)/QCS/Cu-BGs (PQB-Cu) multi-network hydrogels were fabricated via a freeze-thaw cycling process. The 4wt% Cu-BGs exhibited a spherical morphology with a homogeneous distribution of copper (Cu) throughout the glass matrix. X-ray diffraction (XRD) and Barrett-Emmett-Teller (BET) analyses confirmed its mesoporous nature and amorphous structure. The PQB-0.5%Cu hydrogel formed a three-dimensional network structure through electrostatic interactions and dynamic borate ester bonds, demonstrating interconnected porosity (SEM), self-healing properties that enable painless dressing changes, and superior adhesion strength (13.98±1.77 kPa vs.5 kPa for commercial Greenplast). Additionally, the hydrogel demonstrated a swelling ratio of up to 300%, and its elongation at break was (316.10±41.10)%, markedly exceeding the human skin requirement of 17% to 27%. In vitro studies revealed a biphasic Cuions release profile (initial burst followed by sustained diffusion), while Cu-BGs and QCS synergy enhanced human umbilical vein endothelial cell (HUVEC) migration by 1.26-fold in 24-hour scratch assays. The PQB-Cu multi-network hydrogel developed in this work exhibited favorable mechanical properties and effectively promoted cell migration, offering a promising strategy for the design of wound dressings with excellent mechanical strength and therapeutic potential for wound healing.
Key words:  bioactive glass    hydrogel    multi-network    copper ions
出版日期:  2025-12-25      发布日期:  2025-12-17
ZTFLH:  R313  
基金资助: 新疆维吾尔自治区自然科学基金(2023D01C49);新疆天池英才青年博士项目
通讯作者:  *仝凤莲,新疆医科大学药学院副教授、硕士研究生导师,目前主要从事生物医用材料、柔性电子器件等方面的研究。tongfl@xjmu.edu.cn   
作者简介:  张芮,新疆医科大学药学院硕士研究生,主要从事生物医药材料制备及创面修复的研究。
引用本文:    
张芮, 马晓丽, 仝凤莲. 铜掺杂生物活性玻璃/壳聚糖季铵盐复合水凝胶的构建及多网络协同增强机制[J]. 材料导报, 2025, 39(24): 25040080-8.
ZHANG Rui, MA Xiaoli, TONG Fenglian. Construction of Copper-doped Bioactive Glass/Quaternized Chitosan Composite Hydrogels and Their Multi-network Synergistic Enhancement Mechanism. Materials Reports, 2025, 39(24): 25040080-8.
链接本文:  
https://www.mater-rep.com/CN/10.11896/cldb.25040080  或          https://www.mater-rep.com/CN/Y2025/V39/I24/25040080
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