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材料导报  2025, Vol. 39 Issue (17): 24080189-12    https://doi.org/10.11896/cldb.24080189
  高分子与聚合物基复合材料 |
可注射止血水凝胶的设计原理及粘附能力增强策略
刘姝含1,2, 丁晟1, 侯可心1, 程雅丽1, 张绍辉1, 李钒1,*, 杨焜1,*
1 中国人民解放军军事科学院系统工程研究院,天津 300161
2 天津科技大学生物工程学院工业微生物教育部重点实验室,天津 300457
Design Principle and Adhesion Enhancing Strategies of Injectable Hemostatic Hydrogel
LIU Shuhan1,2, DING Sheng1, HOU Kexin1, CHENG Yali1, ZHANG Shaohui1, LI Fan1,*, YANG Kun1,*
1 Systems Engineering Institute, Academy of Military Sciences, People's Liberation Army, Tianjin 300161, China
2 MOE Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
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摘要 多数可注射水凝胶或是由于缺乏机械强度导致内聚力失效,或是由于组织与生物材料界面相互作用不足而导致无法持续粘结。理想的水凝胶材料应具有适宜的内聚强度以模拟天然组织的刚度和弹性,同时需具备适宜的粘结强度,以实现伤口的物理封堵并抵抗一定强度的机械运动。水凝胶的粘附性能实际由粘结和内聚共同决定,在适宜的平衡范围内,单一增加内聚力或粘结力都可增强粘附效果,但超出平衡范围,内聚与粘结二者将是此消彼长的对立制约关系。掌握可注射止血水凝胶的设计原理及粘附能力增强策略,是止血水凝胶基础研究和应用转化的关键。本文介绍了高强可注射水凝胶的设计原理,并从内聚和粘结两个维度举例分析了粘附能力增强的设计策略和方法,最后对可注射水凝胶设计过程中的注意事项以及未来的发展方向进行了总结和展望。
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刘姝含
丁晟
侯可心
程雅丽
张绍辉
李钒
杨焜
关键词:  可注射  止血水凝胶  粘附能力  内聚强度  粘结强度    
Abstract: Most injectable hydrogels either fail to cohere due to a lack of mechanical strength or have insufficient bonding capacity to sustain adhesion due to insufficient interfacial interaction between tissue and biomaterial. Ideal hydrogel materials should have optimal cohesive strength to mimic the stiffness and elasticity of natural tissues, as well as appropriate bond strength to seal wounds with physical methods and to resist mechanical movement with some intensity. Indeed, the adhesion performance of hydrogel is determined by the bonding and cohesion together;within the appropriate equilibrium, a single increase in cohesion or adhesion can produce adhesion enhancement, but once the balance is destroyed, the two will be opposing constraints on each other. Learning the design principles and adhesion enhancement strategies of injectable hemostatic hydrogels is the key to the research and technology transformation of hemostatic hydrogels. This paper introduces the design principles of high-strength injectable hydrogels and analyzes the design strategies and methods of adhesion enhancement from the dimensions of cohesion and bonding with examples. Finally, we summarize and look forward to the precautions in the process of designing injectable hydrogels as well as the future development direction.
Key words:  injectable    hemostatic hydrogel    adhesion capacity    cohesive strength    bond strength
发布日期:  2025-08-28
ZTFLH:  R318.08  
基金资助: 系统工程研究院自主项目基金(ZZB2023C7010)
通讯作者:  *李钒,博士,中国人民解放军军事科学院卫勤保障技术研究所高级工程师。主要从事止血包扎材料,碳纳米材料在荧光标记、光能转化、光催化等方面的应用基础研究。vanadium_1981@163.com
杨焜,博士,军事科学院系统工程研究院工程师。主要从事止血材料、荧光标记等方面的研究。yangkuntianda@163.com   
作者简介:  刘姝含,天津科技大学生物工程学院硕士研究生,在杨焜工程师指导下开展生物医用水凝胶相关领域研究。
引用本文:    
刘姝含, 丁晟, 侯可心, 程雅丽, 张绍辉, 李钒, 杨焜. 可注射止血水凝胶的设计原理及粘附能力增强策略[J]. 材料导报, 2025, 39(17): 24080189-12.
LIU Shuhan, DING Sheng, HOU Kexin, CHENG Yali, ZHANG Shaohui, LI Fan, YANG Kun. Design Principle and Adhesion Enhancing Strategies of Injectable Hemostatic Hydrogel. Materials Reports, 2025, 39(17): 24080189-12.
链接本文:  
https://www.mater-rep.com/CN/10.11896/cldb.24080189  或          https://www.mater-rep.com/CN/Y2025/V39/I17/24080189
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