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材料导报  2025, Vol. 39 Issue (5): 24090118-6    https://doi.org/10.11896/cldb.24090118
  新型生物医用材料 |
含硼荧光材料及其在硼中子俘获治疗中的应用
庞淼†, 钟天源†, 潘勇, 齐延新*, 黄宇彬*
东北师范大学化学学院,长春 130024
Boron-containing Fluorescent Materials and Their Application in Boron Neutron Capture Therapy
PANG Miao†, ZHONG Tianyuan†, PAN Yong, QI Yanxin*, HUANG Yubin*
Department of Chemistry, Northeast Normal University, Changchun 130024, China
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摘要 硼中子俘获治疗(Boron neutron capture therapy,BNCT)作为一种二元靶向放射疗法,已经显示出强大的抗癌潜力。该治疗方法对肿瘤细胞具有高选择性和杀伤力,其有效性主要取决于足够浓度的10B在肿瘤中积累。在BNCT过程中实时观察硼的组织分布和代谢情况一直是治疗过程中的挑战。荧光成像作为一种潜在的灵敏光谱技术,是用于评估组织中的硼分布的可靠选择。因此,将BNCT与荧光成像相结合的研究引起人们的广泛关注。本文重点介绍了含硼荧光材料的种类及应用,并对其中应用在BNCT中的荧光材料进行了详细介绍。进一步讨论了这些含硼材料在BNCT中的技术瓶颈以及可能的解决途径。最后,对BNCT中含硼荧光材料的可行设计和应用前景进行了展望,为含硼荧光材料的设计提供了新的指导。
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庞淼
钟天源
潘勇
齐延新
黄宇彬
关键词:  硼中子俘获治疗  成像  荧光分子  多孔材料    
Abstract: Boron neutron capture therapy (BNCT), as a binary targeted radiotherapy, has shown strong anti-cancer potential. This treatment is highly selective and lethal to tumor cells, and its effectiveness mainly depends on the accumulation of sufficient concentrations of 10B in the tumor. Real-time observation of boron’s tissue distribution and metabolism during the BNCT process has always been a challenge in the treatment. Fluorescence imaging, as a potential sensitive spectral technique, is a reliable choice for evaluating boron distribution in tissues. Therefore, research combining BNCT with fluorescence imaging has attracted widespread attention. In this review, we focus on the types and applications of boron-containing fluorescent materials and provide a detailed introduction to the fluorescent materials applied in BNCT. Further, we discuss the technical bottlenecks of these boron-containing materials in BNCT and possible solutions. Finally, we look forward to the feasible design and application prospects of boron-containing fluorescent materials in BNCT, providing new guidance for the design of boron-containing fluorescent materials.
Key words:  boron neutron capture therapy    imaging    fluorescent molecule    porous material
出版日期:  2025-03-10      发布日期:  2025-03-18
ZTFLH:  R914.2  
基金资助: 国家自然科学基金面上项目(52273124);深圳市科技计划资助(JCYJ20230807112801003);中央高校基本科研业务费-青年教师启动基金(2412023QD017)
通讯作者:  *齐延新,博士,东北师范大学化学学院副教授、博士研究生导师。目前主要研究方向为硼中子俘获治疗和药物载体等。qiyx001@nenu.edu.cn
黄宇彬,博士,东北师范大学化学学院教授、博士研究生导师。目前主要从事生物医用材料和硼中子俘获治疗方面的研究。huangyb350@nenu.edu.cn   
作者简介:  庞淼,东北师范大学化学学院硕士研究生,在黄宇彬教授和齐延新副教授的指导下进行研究。目前主要研究领域为硼中子俘获治疗。
钟天源,东北师范大学化学学院博士研究生,在黄宇彬教授和齐延新副教授的指导下进行研究。目前主要研究领域为硼中子俘获治疗。†共同第一作者
引用本文:    
庞淼, 钟天源, 潘勇, 齐延新, 黄宇彬. 含硼荧光材料及其在硼中子俘获治疗中的应用[J]. 材料导报, 2025, 39(5): 24090118-6.
PANG Miao, ZHONG Tianyuan, PAN Yong, QI Yanxin, HUANG Yubin. Boron-containing Fluorescent Materials and Their Application in Boron Neutron Capture Therapy. Materials Reports, 2025, 39(5): 24090118-6.
链接本文:  
https://www.mater-rep.com/CN/10.11896/cldb.24090118  或          https://www.mater-rep.com/CN/Y2025/V39/I5/24090118
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