Please wait a minute...
材料导报  2023, Vol. 37 Issue (15): 22010219-7    https://doi.org/10.11896/cldb.22010219
  无机非金属及其复合材料 |
Fe3O4磁性纳米药物用于克服肿瘤多药耐药性的研究
唐昭敏*, 田维君
西南石油大学新能源与材料学院,成都 610500
Study on Fe3O4-based Magnetic Nanomedicine for Overcoming Multidrug Resistance in Cancer
TANG Zhaomin*, TIAN Weijun
School of New Energy and Materials, Southwest Petroluem University, Chengdu 610500, China
下载:  全 文 ( PDF ) ( 31810KB ) 
输出:  BibTeX | EndNote (RIS)      
摘要 肿瘤多药耐药性(MDR)是癌症化疗的主要障碍。因此,研发能克服MDR的药物传递系统显得尤为必要。本工作设计了一种以Fe3O4为载体的磁性纳米药物Fe3O4@PDA-TPP/S2-PEG-hyd-DOX (Fe3O4-ATSPD),采用化疗协同光热疗法(PTT)联合克服肿瘤的多药耐药性。该纳米药物在血液循环中表现出很高的稳定性,能通过磁靶向增强实体瘤的高通透性和滞留效应(EPR)在肿瘤部位富集,从而提高抑瘤率。当肿瘤细胞吞噬纳米药物后,在胞内酸性条件下,Fe3O4-ATSPD释放出抗肿瘤药物DOX进入细胞核。同时,在高浓度谷胱甘肽(GSH)作用下断裂二硫键,暴露出线粒体靶向基团三苯基膦(TPP)改性的光热剂Fe3O4-AT。使用近红外光(NIR)照射肿瘤组织时,线粒体中的Fe3O4-AT快速产生光热效应,扰乱线粒体功能。体内外实验结果表明,化疗协同光热治疗具有最佳的抗肿瘤效果和安全性。
服务
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章
唐昭敏
田维君
关键词:  多药耐药  线粒体靶向  近红外照射  肿瘤治疗    
Abstract: Multidrug resistance (MDR) of tumor is a major obstacle to the treatment of cancer. Therefore, it is necessary to develop a drug delivery system that can overcome MDR. In this work, a magnetic nanomedicine Fe3O4@PDA-TPP/S2-PEG-hyd-DOX (Fe3O4-ATSPD) was designed, and chemotherapy combined with photothermal therapy (PTT) was used to overcome MDR of tumor. This nanomedicine shows high stability in blood circulation, and can be accumulated at the tumor site through the magnetic targeting enhanced high permeability and retention effect (EPR). When intracellular uptake by tumor cells, DOX is released from Fe3O4-ATSPD under acidic condition. Meanwhile, the disulfide bond is broken with the high concentration of glutathione (GSH), exposing the targeting group of triphenylphosphine (TPP) modified photothermal agent Fe3O4-AT. After near-infrared light (NIR) irradiation, the photothermal effect is generated quickly, leading to the mitochondrial dysfunction. The experimental results in vitro and in vivo show that chemotherapy combined with PTT has the best antitumor effect and safety.
Key words:  multidrug resistance    mitochondrial-targeting    near infrared irradiation    cancer therapy
出版日期:  2023-08-10      发布日期:  2023-08-07
ZTFLH:  R730.53  
基金资助: 国家自然科学基金(51803174)
通讯作者:  * 唐昭敏,博士,西南石油大学新能源与材料学院讲师、硕士研究生导师,主要从事新型功能材料用于肿瘤研究。作为课题组负责人主持国家自然科学基金一项,以第一作者及通信作者在Biomaterials、Acta Biomaterialia、Advanced Healthcare Materials、Separation and Purification Technology、Microporous and Mesoporous Materials、Molecular Pharmaceutics及European Journal of Pharmaceutics and Biopharmaceutics等高水平期刊上发表多篇SCI论文。tl8687@163.com   
引用本文:    
唐昭敏, 田维君. Fe3O4磁性纳米药物用于克服肿瘤多药耐药性的研究[J]. 材料导报, 2023, 37(15): 22010219-7.
TANG Zhaomin, TIAN Weijun. Study on Fe3O4-based Magnetic Nanomedicine for Overcoming Multidrug Resistance in Cancer. Materials Reports, 2023, 37(15): 22010219-7.
链接本文:  
http://www.mater-rep.com/CN/10.11896/cldb.22010219  或          http://www.mater-rep.com/CN/Y2023/V37/I15/22010219
1 Wang Y G,Li X H,Chen P Y,et al.Nanoscale,2020,12(3),1886.
2 Hu Y,Wang R Z,Wang S G,et al.Scientific Reports,2016,6,28325.
3 Luo K I,Zhao J L,Jia C Z,et al.ACS Applied Materials & Interfaces,2020,12(20),22650.
4 Li S H,Liu L,Yu Y F,et al.Journal of Alloys and Compounds,2017,698,20.
5 Qi Z J,Joshi T P,Liu R P,et al.Journal of Hazardous Materials,2017,329(17),193.
6 Song X M,Tan L C,Ma H Y,et al.Dalton Transactions,2017,46(10),3347.
7 Niu H L,Lu J H,Song J J,et al.Industrial and Engineering Chemistry Research,2016,55(31),8527.
8 Parandhaman T,Pentela N,Ramalingam B,et al.ACS Sustainable Chemistry and Engineering,2017,5(1),489.
9 Xie W H,Gu L L,Sun X L,et al.Electrochimica Acta,2016,220(16),107.
10 Yang X H,Kan J R,Zhang F Y,et al.Journal of Inorganic and Organometallic Polymers and Materials,2017,27(2),542.
11 Weidenfeller B,Hofer M,Schilling F,et al.Composites Part A,2002,33(8),1041.
12 Khollam Y B,Dhage S R,Potdar H S,et al.Materials Letters,2002,56(4),571.
13 Khandhar A P,Ferguson R M,Krishnan K M.Journal of Applied Physics,2011,109 (7),7B310.
14 Li D,Deng M W,Yu Z Y,et al.ACS Biomaterials Science and Engineering,2018,4(6),2143.
15 Tian R,Zhu L,Qin Z N,et al.Biomaterials Science,2019,7 (12),5258.
16 Zheng S H,Jin S,Wang W,et al.Drug Delivery,2021,28(1),787.
17 Wang Y,Wei G Q,Zhang X B,et al.Small,2018,14(12),e1702994.
18 Baghban N,Yilmaz E,Soylak M.Microchimica Acta,2017,184(10),3969.
19 Almessiere M A,Slimani Y,Sertkol M,et al.Ceramics International,2019,45 (13),16147.
20 Slimani Y,Almessiere M,Guner S,et al.Journal of Materials Science,2019,30(10),9143.
21 Li B B,Xu Q N,Li X F,et al.Carbohydrate Polymers,2019,203,378.
22 Yang Y X,Li M,Liang J Y,et al.ACS Applied Materials & Interfaces,2021,13(13),14894.
23 Wang D D,Yao Y Z,He J K,et al.Advanced Science,2020,7(3),1901293.
24 Zhang X D,Chen X K,Guo Y X,et al.Nanoscale Horizons,2020,5(3),481.
25 Chen X K,Zhang X D,Guo Y X,et al.Advanced Functional Materials,2019,29(13),1807772.
26 Zhu Y X,Jia H R,Duan Q Y,et al.Wiley Interdisciplinary Reviews:Nanomedicine and Nanobiotechnology,2021,13(5),e1715.
27 Sun W,Du Y,Liang X L,et al.Biomaterials,2019,217,119264.
28 Schililer J H,Harrington D,Belani C P,et al.New England Journal of Medicine,2002,346(2),92.
29 Ling X,Chen X,Riddell I A,et al.Nano Letters,2018,18(7),4618.
30 Chen W,Shi K,Chu B Y,et al.Nano Letters,2019,19(5),2905.
31 Li S L,Saw P E,Lin C H,et al.Biomaterials,2020,234,119760.
32 Cao Y,Wu T,Dai W,et al.Chemistry of Materials,2019,31(21),9105.
33 Yuan P,Mao X,Wu X,et al.Angewandte Chemie International Edition,2019,58(23),7657.
34 Huang W J,Zhao H,Wan J S,et al.Theranostics,2019,9(13),3825.
35 Liu J,Sun Z K,Deng Y H,et al.Angewandte Chemie,2009,48(32),5989.
36 Wang X D,Liu Z N,Jin R H,et al.Acta Biomaterialia,2021,128,408.
37 Zhen S,Chen W H,Liu J H,et al.ACS Applied Materials & Interfaces,2021,13(30),35568.
38 Dong X L,Sun Y,Li Y Y,et al.Small,2021,17(18),e2007672.
39 Jiang L,Zhou S S,Zhang X K,et al.Nature Communications,2021,12(1),2390.
[1] 叶舒岳, 冯雅丽, 史海斌. 智能响应型小分子探针在肿瘤诊疗方面的研究进展[J]. 材料导报, 2022, 36(3): 21120202-15.
[2] 贾斐, 杜传超, 毛天立, 刘宇, 刘晓光. 纳米载体共递送基因和化疗药物用于肿瘤治疗的研究进展[J]. 材料导报, 2022, 36(17): 20080171-9.
[3] 吴天怡, 龚妍春, 李资玲, 李玉萍, 熊向源. 抗癌纳米药物共递送系统的应用研究[J]. 材料导报, 2020, 34(Z1): 516-522.
[4] 王怀基, 董海青. 还原响应的白蛋白纳米颗粒负载甲氨蝶呤用于抗肿瘤治疗[J]. 材料导报, 2019, 33(Z2): 547-552.
[5] 杨焜, 王春来, 丁晟, 刘长军, 田丰, 李钒. 荧光碳量子点:合成、特性及在肿瘤治疗中的应用[J]. 材料导报, 2019, 33(9): 1475-1482.
[1] Yanzhen WANG, Mingming CHEN, Chengyang WANG. Preparation and Electrochemical Properties Characterization of High-rate SiO2/C Composite Materials[J]. Materials Reports, 2018, 32(3): 357 -361 .
[2] Yimeng XIA, Shuai WU, Feng TAN, Wei LI, Qingmao WEI, Chungang MIN, Xikun YANG. Effect of Anionic Groups of Cobalt Salt on the Electrocatalytic Activity of Co-N-C Catalysts[J]. Materials Reports, 2018, 32(3): 362 -367 .
[3] Qingshun GUAN,Jian LI,Ruyuan SONG,Zhaoyang XU,Weibing WU,Yi JING,Hongqi DAI,Guigan FANG. A Survey on Preparation and Application of Aerogels Based on Nanomaterials[J]. Materials Reports, 2018, 32(3): 384 -390 .
[4] Lijing YANG,Zhengxian LI,Chunliang HUANG,Pei WANG,Jianhua YAO. Producing Hard Material Coatings by Laser-assisted Cold Spray:a Technological Review[J]. Materials Reports, 2018, 32(3): 412 -417 .
[5] Zhiqiang QIAN,Zhijian WU,Shidong WANG,Huifang ZHANG,Haining LIU,Xiushen YE,Quan LI. Research Progress in Preparation of Superhydrophobic Coatings on Magnesium Alloys and Its Application[J]. Materials Reports, 2018, 32(1): 102 -109 .
[6] Wen XI,Zheng CHEN,Shi HU. Research Progress of Deformation Induced Localized Solid-state Amorphization in Nanocrystalline Materials[J]. Materials Reports, 2018, 32(1): 116 -121 .
[7] Xing LIANG, Guohua GAO, Guangming WU. Research Development of Vanadium Oxide Serving as Cathode Materials for Lithium Ion Batteries[J]. Materials Reports, 2018, 32(1): 12 -33 .
[8] Hao ZHANG,Yongde HUANG,Yue GUO,Qingsong LU. Technological and Process Advances in Robotic Friction Stir Welding[J]. Materials Reports, 2018, 32(1): 128 -134 .
[9] Laima LUO, Mengyao XU, Xiang ZAN, Xiaoyong ZHU, Ping LI, Jigui CHENG, Yucheng WU. Progress in Irradiation Damage of Tungsten and Tungsten AlloysUnder Different Irradiation Particles[J]. Materials Reports, 2018, 32(1): 41 -46 .
[10] Fengsen MA,Yan YU,Jie ZHANG,Haibo CHEN. A State-of-the-art Review of Cytotoxicity Evaluation of Biomaterials[J]. Materials Reports, 2018, 32(1): 76 -85 .
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed