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材料导报  2022, Vol. 36 Issue (3): 21090149-17    https://doi.org/10.11896/cldb.21090149
  生物医用材料 |
高分子医用组织胶粘剂的应用与研究进展
孙文1,2, 闫秋艳1, 苏超3, 栾世方1,2, 殷敬华1
1 中国科学院长春应用化学研究所,长春 130022
2 中国科学技术大学应用化学与工程学院,合肥 230026
3 威海市科技创新发展中心,山东 威海 264200
The Applications and Research Progress of Polymeric Medical Tissue Adhesives
SUN Wen1,2, YAN Qiuyan1, SU Chao3, LUAN Shifang1,2, YIN Jinghua1
1 Changchun Institute of Applied Chemistry Chinese Academy of Sciences, Changchun 130022, China
2 School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
3 Weihai Science and Technology Innovation Development Center, Weihai 264200, Shandong, China
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摘要 高分子医用组织胶粘剂由于具有优异的性能,受到医疗领域的广泛关注,适用于轻微至危及生命的各种组织损伤的闭合与再生。与传统的伤口缝合方法(缝合线和缝合钉)相比,胶粘剂使用方便、闭合伤口速度快、对组织的损伤小。目前,高分子医用胶粘剂以多种形式用于伤口处理,如止血剂、粘合剂和密封剂。尽管组织胶粘剂目前应用广泛,但仍面临一些限制和未解决的挑战(例如较弱的湿态粘附强度和缺乏生物功能等),这限制了它们的使用,为未来的改进留下了充足的空间。基于组织胶粘剂界面的化学和物理特性、组织粘连的基本机制以及特定临床应用的要求,本文总结了组织胶粘剂的基本设计原则及湿态粘附机制,基于组织特异性的考虑,介绍了该领域的最新研究进展,并展望了未来组织胶粘剂的潜在功能和临床需求。
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孙文
闫秋艳
苏超
栾世方
殷敬华
关键词:  组织胶粘剂  粘附机制  湿态粘附  组织修复    
Abstract: The polymer medical tissue adhesive has received extensive attention in the medical field due to its excellent performance, and are widely used in a variety of medical settings ranging from minor to life-threatening tissue injuries. Compared to the traditional methods of wound closure (i.e., suturing and stapling), they are relatively easy to use, enable rapid application, and introduce minimal tissue damage. Polymeric tissue adhesives can provide versatile materials for wound management, and can be used as hemostatic agents, adhesives and sealants. Despite their numerous current applications, tissue adhesives still face several limitations and unresolved challenges (e.g., weak wet adhesion strength and poor biological function). Successful development of next-generation adhesives will likely require a holistic understanding of the chemical and physical properties of the tissue-adhesive interface, fundamental mechanisms of tissue adhesion, and requirements for specific clinical applications. In this review, we discussed the basic design principles and wet adhesion mechanism of tissue adhesives. Based on the consideration of tissue specificity, we introduced the latest research progress in this field and looked forward to the potential functions and clinical needs of tissue adhesives in the future, hoping to provide a valuable reference for the progress in the field of tissue adhesive.
Key words:  tissue adhesive    adhesion mechanism    wet adhesion    tissue repair
发布日期:  2022-02-10
ZTFLH:  TB324  
基金资助: 国家重点研发计划(2021YFC2101700);中国科学院-威高集团高新技术研发计划
通讯作者:  qyyan@ciac.ac.cn;yinjh@ciac.ac.cn   
作者简介:  孙文,2018年6月毕业于海南大学,获得学士学位。现为中国科学院长春应用化学研究所博士研究生,在栾世方研究员的指导下进行研究。目前主要研究领域为医用软组织胶。
闫秋艳,中国科学院长春应用化学研究所助理研究员。2012年6月本科毕业于商丘师范学院生命科学学院,2015年6月硕士毕业于吉林大学生命科学学院,2019年1月在中国科学院长春应用化学研究所分析专业取得博士学位。主要从事组织粘合剂和细菌粘附机制的研究工作。
殷敬华,威高集团总工程师,中国科学院长春应用化学研究所研究员、博士研究生导师。1970年毕业于南京化工大学,1981年12月于中国科学院长春应用化学研究所获理学硕士学位。曾任中国生物材料学会常务理事、中国材料学会高分子材料分会副理事长、中国科学院长春应用化学研究所学术委员会主任。主要研究领域:生物医用高分子材料与医疗器械。发表研究论文280多篇,撰写专著2部,获得国家技术发明二等奖、国家科技进步二等奖。
引用本文:    
孙文, 闫秋艳, 苏超, 栾世方, 殷敬华. 高分子医用组织胶粘剂的应用与研究进展[J]. 材料导报, 2022, 36(3): 21090149-17.
SUN Wen, YAN Qiuyan, SU Chao, LUAN Shifang, YIN Jinghua. The Applications and Research Progress of Polymeric Medical Tissue Adhesives. Materials Reports, 2022, 36(3): 21090149-17.
链接本文:  
http://www.mater-rep.com/CN/10.11896/cldb.21090149  或          http://www.mater-rep.com/CN/Y2022/V36/I3/21090149
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