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材料导报  2026, Vol. 40 Issue (9): 25010131-8    https://doi.org/10.11896/cldb.25010131
  高分子与聚合物基复合材料 |
羊毛角蛋白亲水性纳米纤维膜的制备及性能
章书琦, 张晶, 徐成书*, 尚玉栋, 任燕, 张鑫卿
西安工程大学纺织科学与工程学院,西安 710048
Preparation and Properties of Hydrophilic Nanofiber Membrane Based onWool Keratin
ZHANG Shuqi, ZHANG Jing, XU Chengshu*, SHANG Yudong, REN Yan, ZHANG Xinqing
College of Textile Science and Technology, Xi’an Polytechnic University, Xi’an 710048, China
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摘要 角蛋白基的纳米纤维膜在创面敷料领域展现出重要应用潜力。然而,如何通过材料设计实现同时维持纤维膜的亲水性和水稳定性,仍是当前研究的难点。为制备孔隙率高、水稳定性优异和亲水性良好的纳米纤维膜,本研究以聚乙烯醇(PVA)、羊毛角蛋白(KE)、抗菌因子苯扎氯铵(BKC)为原料,利用静电纺丝工艺和热交联,构建了在常温下和40 ℃的水浴下稳定的三组分纳米纤维膜,并对纤维膜的表观形貌、化学结构、热稳定性、亲水性能和孔隙率等相关指标进行测试。结果表明,6%(质量分数)PVA组别中,PVA、KE、BKC质量比为1∶0.25∶0.1的组别与二组分纤维膜相比综合性能最优。PVA/KE/BKC纤维膜的水稳定性、亲水性能可通过纺丝液的配比和热交联的方法进行调节,有望应用于伤口敷料领域。
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章书琦
张晶
徐成书
尚玉栋
任燕
张鑫卿
关键词:  纳米纤维  静电纺丝  抗菌  角蛋白  苯扎氯铵    
Abstract: Keratin-based nanofibrous membranes hold significant promise for wound dressings; however, developing fibrous membranes that simulta-neously maintain good hydrophilicity and water stability remains challenging. To fabricate nanofiber membranes with high porosity, favorable water stability, and good hydrophilicity, this study utilized polyvinyl alcohol (PVA), wool keratin (KE) and antibacterial agent benzalkonium chloride (BKC) as raw materials. A three-component nanofiber membrane stable in water at room temperature and 40 ℃ was constructed via electrospinning followed by thermal crosslinking. The membranes’ apparent morphology, chemical structure, thermal stability, wettability and porosity were characterized. Results demonstrated that, compared to two-component fiber membranes, the membrane prepared from a 6wt% PVA solution with a PVA/KE/BKC mass ratio of 1∶0.25∶0.1 exhibited optimal water stability while maintaining good hydrophilicity. The water stability and wettability of the PVA/KE/BKC fiber membrane can be tailored by adjusting the spinning solution composition and the thermal crosslinking method, indicating its potential application in wound dressings.
Key words:  nanofiber    electrospinning    antibacterial    keratin    benzalkonium chloride
收稿日期:  2026-05-10      出版日期:  2026-05-10      发布日期:  2026-05-18
ZTFLH:  TQ340.64  
基金资助: 陕西省教育厅科学研究计划青年创新团队项目(24JP064);特种FH纺织品教育部重点实验室开放课题(TZFH-24-009);纺织新材料及其应用湖北省重点实验室开放项目(FZXCL202303);2023年度陕西高等教育教学改革研究项目(23ZY018);陕西省秦创原“科学家+工程师”队伍建设项目(2025QCY-KXJ-084);新疆维吾尔自治区“揭榜挂帅”项目
通讯作者:  *徐成书,博士,西安工程大学纺织科学与工程学院教授、博士研究生导师。主要从事轻化工程的教学与科研工作。xcs7910@163.com   
作者简介:  章书琦,西安工程大学纺织科学与工程学院硕士研究生,在张晶副教授和徐成书教授的指导下从事蛋白质基复合纤维的研究。
引用本文:    
章书琦, 张晶, 徐成书, 尚玉栋, 任燕, 张鑫卿. 羊毛角蛋白亲水性纳米纤维膜的制备及性能[J]. 材料导报, 2026, 40(9): 25010131-8.
ZHANG Shuqi, ZHANG Jing, XU Chengshu, SHANG Yudong, REN Yan, ZHANG Xinqing. Preparation and Properties of Hydrophilic Nanofiber Membrane Based onWool Keratin. Materials Reports, 2026, 40(9): 25010131-8.
链接本文:  
https://www.mater-rep.com/CN/10.11896/cldb.25010131  或          https://www.mater-rep.com/CN/Y2026/V40/I9/25010131
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