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材料导报  2026, Vol. 40 Issue (8): 25020165-7    https://doi.org/10.11896/cldb.25020165
  金属与金属基复合材料 |
金属基纳米材料在口腔感染性疾病抗菌领域中的最新研究
刘沿1, 杨睿萱1, 刘晓萌2, 李启艳3,*, 潘洁3,*
1 大理大学药学院,云南 大理 671000
2 昆明理工大学材料科学与工程学院,昆明 650093
3 云南省第一人民医院口腔医学中心,昆明 650032
The State of the Art of Metal-based Nanomaterials for Oral Infectious Diseases
LIU Yan1, YANG Ruixuan1, LIU Xiaomeng2, LI Qiyan3,*, PAN Jie3,*
1 College of Pharmacy, Dali University, Dali 671000, Yunnan, China
2 School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China
3 Stomatology Center, The First People’s Hospital of Yunnan Province, Kunming 650032, China
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摘要 定植于独特微环境中的口腔微生物群是人类微生态体系的重要组成部分。口腔微生态平衡的破坏会显著增强微生物毒力因子表达,改变代谢产物,进而诱发龋病、牙髓病、根尖周病、牙周病和植体周病等口腔感染性疾病。近年来,在生物医学材料领域的前沿研究中,纳米材料凭借其独特的性能脱颖而出,尤其是金属基纳米材料因其超小粒径、高表面积和良好的表面配体等独特优势,在治疗口腔感染性疾病中展现出卓越的抗菌性能。与此同时,为解决日益严峻的抗生素耐药性问题,金属基纳米材料作为新型抗菌制剂,在口腔微生态调控及口腔感染性疾病防治中展现出重要应用价值。本文综述了金属基纳米材料的分类、抗菌特性、抗菌机制以及在治疗口腔感染性疾病中的最新研究,旨在为口腔感染性疾病的防治提供理论依据,为金属基纳米材料的临床转化提供参考。
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刘沿
杨睿萱
刘晓萌
李启艳
潘洁
关键词:  金属基纳米材料  抗菌机制  龋病  牙髓病  根尖周病  牙周病  植体周病    
Abstract: The oral microbiota, colonizing a unique microenvironment, is an important component of the human microecological system. Disruption of the oral microecological balance significantly increases the expression of microbial virulence factors and alters metabolites, increasing the incidence of oral infectious diseases such as caries, endodontics, periapical disease, and periodontitis. In recent years, cutting-edge research in the field of biomedical materials has highlighted the potential of nanomaterials by virtue of their unique characteristics. Metal-based nanomaterials in particular have demonstrated excellent antimicrobial properties due to their unique advantages of ultra-small particle size, large surface area, and effective surface ligands. Meanwhile, in order to solve the increasingly serious problem of antibiotic resistance, metal-based nanomaterials, as a new type of antimicrobial agent, have been shown a great potential for the regulation of oral microecology, the prevention and treatment of oral infectious diseases. This summary reviews the classification, antimicrobial properties, antimicrobial mechanisms, and the latest research on metal-based nanomaterials in oral infectious diseases, aiming to provide a theoretical basis for the prevention and treatment of such diseases, and providing a reference for the clinical translation of metal-based nanomaterials.
Key words:  metal-based nanomaterial    antibacterial mechanism    caries    endodontics    periapical disease    periodontitis    peri-implant disease
出版日期:  2026-04-25      发布日期:  2026-05-06
ZTFLH:  R459.9  
  R318.08  
  R780.1  
基金资助: 院内博士项目(KHBS-2022-003);昆医联合专项—面上项目(202201AY070001-239);云南省基础研究项目(202501AS070032)
通讯作者:  * 李启艳,主任医师,博士研究生导师。长期从事牙周疾病的病因和治疗等相关领域的研究。301605@kust.edu.cn
潘洁,主治医师,硕士研究生导师。长期从事口腔基础医学和生物纳米材料等相关领域的研究。JiePandoctorpanj@163.com   
作者简介:  刘沿,大理大学药学院硕士研究生,在李启艳教授的指导下研究铋基纳米材料抗菌机制。
引用本文:    
刘沿, 杨睿萱, 刘晓萌, 李启艳, 潘洁. 金属基纳米材料在口腔感染性疾病抗菌领域中的最新研究[J]. 材料导报, 2026, 40(8): 25020165-7.
LIU Yan, YANG Ruixuan, LIU Xiaomeng, LI Qiyan, PAN Jie. The State of the Art of Metal-based Nanomaterials for Oral Infectious Diseases. Materials Reports, 2026, 40(8): 25020165-7.
链接本文:  
https://www.mater-rep.com/CN/10.11896/cldb.25020165  或          https://www.mater-rep.com/CN/Y2026/V40/I8/25020165
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