Abstract: The carbonylation of alkyne to form α, β-unsaturated carbonyl compounds is an important intermediate for many basic organic synthesis, which has great application value in drug synthesis, agricultural chemicals, spices and so on. The effective utilization of C1 resources makes the palladium-catalyzed carbonylation have atom economy and high selectivity. The first palladium catalyst system to obtain α, β-unsatura-ted carbonyl compounds was a homogeneous palladium salt system with strong acids, metal salts as cocatalysts. In the following decades, researchers used solid organic acid to reduce its pollution to the environment and equipment, then developed new ligand systems to improve the conversion and selectivity of the reaction. Homogeneous system is not easy to be separated and purification, which limits its application. In recent years, people′s focus has been on heterogeneous catalysis. Loading palladium catalyst on porous solid surface can not only increase specific surface area and have more active sites, but also solve the problem of difficult separation of product and catalyst. In this review,we mainly describe the related reports of palladium catalyzed carbonylation of terminal alkynes. The effects of solvents, promoters and ligands in homogeneous system on the products of alkyne catalyzed carbonylation are introduced. At the same time, the research progress of heterogeneous palladium catalyzed carbonylation of alkynes is also summarized. The development trend and direction of palladium catalyzed carbonylation of terminal alkynes are prospected.
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2020, Vol. 34 
