PEEK with Glucose Responsive Coating for Diabetic Bone Defects Antibiotic Therapy
XIE Kenan1,*, HE Yujia2, ZHANG Qi3, XIE Lu4, HE Wenxuan5
1 School of Liquor-Brewing Engineering, Sichuan University Jinjiang College, Meishan 620860, Sichuan, China 2 Shijiazhuang Medical College, Shijiazhuang 050500, China 3 Jiannanchun Distillery Co., Ltd., Mianzhu 618200, Sichuan, China 4 Department of Restoration, West China School/Hospital of Stomatology, Sichuan University, Chengdu 610041, China 5 School of Chemical Engineering, Sichuan University, Chengdu 610065, China
Abstract: The characteristics of high glucose concentration and low pH value in the wound microenvironment of diabetic patients make them vulnerable to the invasion of pathogens, dysfunction of bone cells and the induction of osteoclasts, which extremely affects the repair efficacy of implantation surgery. Presently, polyetheretherketone (PEEK) has become a promising bone implant. But its poor antibacterial ability, poor osteogenic capability and unable to respond to the microenvironment of diabetes restrictes the further application. To reverse such defects, a glucose response coating composed of copper (Cu) chelated polydopamine (PDA) metal polyphenol network (Cu/MPN) and glucose oxidase (GOx) was constructed on the surface of PEEK. After analyzing the surface morphology, chemical composition, Zeta potential and water contact angle of the modified implants, the loading capacities of GOx, temperature curves under NIR and abilities to produce H2O2 and ·OH in vitro were further verified. Finally, antibacterial and biosafety tests were conducted. The results indicated that we successfully constructed Cu/MPN@GOx coating on the PEEK surface, and it can produce H2O2 and further react to ·OH when glucose exists. The coating had significant antibacterial effects on S.aureus and E.coli in high sugar microenvironment and it did not exhibit cytotoxicity. In conclusion, the new strategy of glucose sensitive antibacterial and osteogenic coating modification proposed in this study has laid an experimental foundation for the treatment of intractable diabetic bone defects.
1 Tian P, Zhao L, Kim J, et al. Bioactive Materials, 2023, 26, 231. 2 Shu R, Sun J, Li B, et al. Advanced Functional Materials, 2023, 33 (27), 2214873. 3 Duan J, Wu J L, Lin T, et al. Materials Reports, 2023, 37 (10), 198 (in Chinese). 段晶, 吴佳蕾, 林涛, 等. 材料导报, 2023, 37 (10), 198. 4 Wang H, Fu X, Shi J, et al. Advanced Science, 2021, 8 (20), 2101778. 5 Yi R, Wang F H, Liu Y C, et al. Materials Reports, 2023, 37 (11), 205 (in Chinese). 易荣, 王法衡, 刘永财, 等. 材料导报, 2023, 37 (11), 205. 6 Mo S, Mehrjou B, Tang K, et al. Chemical Engineering Journal, 2020, 392, 123736. 7 Wang X, Pan L, Zheng A, et al. Bioactive Materials, 2023, 24, 236. 8 Qi Y, Gong J, Yang D Y, et al. Materials Reports, 2019, 33 (10), 1756 (in Chinese). 祁渊, 龚俊, 杨东亚, 等. 材料导报, 2019, 33 (10), 1756. 9 Li B, Shu R, Dai W, et al. Small, 2022, 18 (45), 2203619. 10 Fu L H, Qi C, Hu Y R, et al. Advanced Materials, 2019, 31 (21), 1808325. 11 Fu L H, Qi C, Lin J, et al. Chemical Society Reviews, 2018, 47 (17), 6454. 12 Fang C, Deng Z, Cao G, et al. Advanced Functional Materials, 2020, 30 (16), 1910085. 13 Lyu M, Zhu D, Kong X, et al. Advanced Healthcare Materials, 2020, 9 (11), 1901819. 14 Wang T, Dong D, Chen T, et al. Chemical Engineering Journal, 2022, 446, 137172. 15 Deng Y, Ouyang X, Sun J, et al. Bioactive Materials, 2023, 25, 748. 16 Zhu Y, Archer W R, Morales K F, et al. Angewandte Chemie, 2023, 135 (22), 202302303. 17 Ma B, Wang S, Liu F, et al. Journal of the American Chemical Society, 2018, 141 (2), 849. 18 Zhang S, Jin L, Liu J, et al. Advanced Functional Materials, 2022, 32 (23), 2113397. 19 Fu L H, Wan Y, Qi C, et al. Advanced Materials, 2021, 33 (7), 2006892. 20 Alfieri M L, Weil T, Ng D Y W, et al. Advances in Colloid and Interface Science, 2022, 305, 102689. 21 Fu Y, Yang L, Zhang J, et al. Materials horizons, 2021, 8 (6), 1618. 22 Ding F, Gao X, Huang X, et al. Biomaterials, 2020, 245, 119976. 23 Getachew G, Korupalli C, Rasal A S, et al. Composites Part B:Engineering, 2021, 226, 109364. 24 Zhan L, Yin X, Zhang Y, et al. Biomaterials Advances, 2023, 146, 213306.
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2025, Vol. 39 
