基于“酚-胺”化学构建抗污表面的研究

doi:10.11896/cldb.22030171

材料导报

2023, Vol. 37

Issue (17): 22030171-6 https://doi.org/10.11896/cldb.22030171

高分子与聚合物基复合材料

基于“酚-胺”化学构建抗污表面的研究

谢鑫, 吕楠, 涂秋芬^*

西南交通大学材料科学与工程学院,成都 610031

Construction of Antifouling Surface Based on Phenol-Amine Chemistry

XIE Xin, LYU Nan, TU Qiufen^*

School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China

摘要
参考文献
相关文章
推荐阅读
Metrics

下载:

全文 ( PDF ) ( 23436KB )
输出: BibTeX | EndNote (RIS)

摘要生物污染是医用器械植、介入后的常见问题,尤其是血液接触类器械,如体外循环导管等。生物污染除了影响器械功能发挥外,还可能危及患者生命安全。在器械表面构建抗污涂层是解决此类问题行之有效的策略之一。本工作的灵感来源于“酚-胺”化学,利用ε-聚赖氨酸 (ε-PL)、氢化咖啡酸 (HCA)、高碘酸钠(NaIO₄)一步浸涂法,快速、高效地构建了ε-PL/HCA“酚-胺”涂层,利用涂层表面丰富的氨基官能团接枝透明质酸(HA),得到具有良好生物除污功能的HA@ε-PL/HCA涂层。傅里叶红外光谱(FTIR)、X射线光电子能谱(XPS)、水接触角的结果证明成功制备了HA@ε-PL/HCA涂层;三种细胞的粘附实验证明HA@ε-PL/HCA涂层具有优异的抗细胞粘附能力;体外血小板粘附与半体内血液循环试验表明HA@ε-PL/HCA涂层具有良好的抗凝血能力。综上,基于“酚-胺”化学构建的HA@ε-PL/HCA涂层可赋予材料良好的抗凝血、抑制细胞粘附的功能,在体外循环导管等器械的表面改性方面具有潜在的应用价值。

	服务
	把本文推荐给朋友
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	谢鑫
	吕楠
	涂秋芬

关键词: “酚-胺”化学 ε-聚赖氨酸氢化咖啡酸透明质酸抗污抗凝

Abstract: Biological contamination is a common problem after implantation and intervention of medical devices,especially blood contact class devices,such as extracorporeal circulation catheters,etc.In addition to affecting the function of devices,biological contamination may also endanger the life of patients.The construction of anti-fouling coatings on device surfaces is one of the most effective strategies to address such problems.The present work was inspired by phenol-amine chemistry and utilizes ε-polylysine (ε-PL),hydrogenated caffeic acid (HCA),and sodium periodate (NaIO₄) in a one-step dip coating method to rapidly and efficiently construct ε-PL/HCA phenol-amine coatings.The HA@ε-PL/HCA coating with good biofouling function was obtained by grafting hyaluronic acid (HA) with abundant amino functional groups on the surface of the coating.The results of Fourier infrared spectroscopy (FTIR),X-ray photoelectron spectroscopy (XPS) and water contact angle demonstrated the successful preparation of HA@ε-PL/HCA coating.Three cell adhesion experiments proved that HA@ε-PL/HCA coating has excellent anti-cell adhesion ability.In vitro platelet adhesion and semi-in vivo blood circulation tests showed that HA@ε-PL/HCA coating has good anti-clotting ability.In conclusion,the HA@ε-PL/HCA coating based on the phenol-amine chemistry has potential applications in the surface modification of devices such as extracorporeal circulation catheters by providing the material with good anti-coagulation and cell adhesion inhibition functions.

Key words: phenol-amine chemistry ε-poly-L-lysine dihydrocaffeic acid hyaluronic acid anti-fouling and anti-caking

出版日期: 2023-09-10 发布日期: 2023-09-05

ZTFLH:

O647

通讯作者: *涂秋芬,西南交通大学材料科学与工程学院副教授,2007年毕业于四川大学获得博士学位,2007—2010年在西南交通大学从事博士后相关研究。研究方向包括生物材料表界面、组织工程与人工器官、生物传感器等。tuqiufen@swjtu.edu.cn

作者简介: 谢鑫,西南交通大学生物医学工程专业硕士研究生,研究方向为血液接触材料的表面改性方法。

引用本文:

谢鑫, 吕楠, 涂秋芬. 基于“酚-胺”化学构建抗污表面的研究[J]. 材料导报, 2023, 37(17): 22030171-6.
XIE Xin, LYU Nan, TU Qiufen. Construction of Antifouling Surface Based on Phenol-Amine Chemistry. Materials Reports, 2023, 37(17): 22030171-6.

链接本文:

http://www.mater-rep.com/CN/10.11896/cldb.22030171 或 http://www.mater-rep.com/CN/Y2023/V37/I17/22030171

1 Ma X X, Yang X L. Advanced Materials Industry, 2018(2), 42(in Chinese).
马晓璇, 杨晓丽. 新材料产业, 2018(2), 42.
2 Sun W, Liu W Y, Wu Z Q, et al. Macromolecular Rapid Communications, 2020, 41(8), 1900430.
3 Pan C J, Nie Y D, Dong Y X. Materials Reports, 2011, 25(23), 80(in Chinese).
潘长江, 聂煜东, 董云肖. 材料导报, 2011, 25(23), 80.
4 Yashoda C, Ravikumar K, Bikramjit B. ACS Biomaterials Science & Engineering, 2019, 5(1), 19.
5 Wei Y, Zhang J X, Zhao W X, et al. New Chemical Materials, 2014, 42(6), 30(in Chinese).
魏雨, 张景迅, 赵文祥, 等. 化工新型材料, 2014, 42(6), 30.
6 Chen M, Qu Y, Yang L, et al. Science in China Series B:Chemistry, 2008, 51(9), 848.
7 Liu Hailiang, Liu Yueming, Qin Yang, et al. Applied Surface Science, 2021, 545, 148985.
8 Uvarova E A, Anisimov A V, Mikhailova M A, et al. Inorganic Materials:Applied Research, 2020, 11(6), 1364.
9 Akdogan E. Surface Innovations, 2018, 7(2), 1.
10 Hu Ying, Yue Min, Yuan Fanshu, et al. Journal of Membrane Science, 2021, 621, 118982.
11 Amirul I M, Young C J, Khalid A, et al. ACS Applied Polymer Materials, 2021, 3(2), 1116.
12 Pinchun C, James J L, Chunjen H. ACS Applied Materials & Interfaces, 2021, 13(22), 25663.
13 Jiang Y, Su Y, Zhao L, et al. Colloids and Surfaces B:Biointerfaces, 2017, 156, 87.
14 Schlenoff J. Langmuir:the ACS Journal of Surfaces and Colloids, 2014, 30(32), 9625.
15 Chen X, Lin Z, Feng Y, et al. Small, 2019, 15, 1903784.
16 Waite J H, Tanzer M L. Science (New York, NY), 1981, 212(4498), 1038.
17 Hong S, Na Y, Choi S, et al. Advanced Functional Materials, 2012, 22(22), 4711.
18 Lee H, Dellatore S M, Miller W M, et al. Science, 2007, 318(5849), 426.
19 Lee S, Kim S, Park J, et al. International Journal of Biological Macromolecules, 2020, 151, 1314.
20 Yang C, Ding X, Ono R, et al. Advanced Materials, 2014, 26(43), 7346.
21 Xia Y, Adibnia V, Shan C, et al. Langmuir, 2019, 35(48), 15535.
22 Xue P, Li Q, Li Y, et al. ACS Applied Materials & Interfaces, 2017, 9(39), 33632.
23 Ma W M, Huang N, Xiong K Q, et al. Materials Reports, 2020, 34(8), 08165(in Chinese).
马文梅, 黄楠, 熊开琴, 等. 材料导报, 2020, 34(8), 08165.

[1]	马文梅, 黄楠, 熊开琴. 基于共价固定高密度透明质酸构建具有抗菌抗凝血双功能的表面[J]. 材料导报, 2020, 34(8): 8165-8171.
[2]	郑宇, 王远, 于晓华. Fe⁺注入增强Ti6Al4V表面喷丸强化层的生物摩擦学性能^*[J]. 《材料导报》期刊社, 2017, 31(2): 46-50.

[1]	Yanzhen WANG, Mingming CHEN, Chengyang WANG. Preparation and Electrochemical Properties Characterization of High-rate SiO₂/C Composite Materials[J]. Materials Reports, 2018, 32(3): 357 -361 .
[2]	Yimeng XIA, Shuai WU, Feng TAN, Wei LI, Qingmao WEI, Chungang MIN, Xikun YANG. Effect of Anionic Groups of Cobalt Salt on the Electrocatalytic Activity of Co-N-C Catalysts[J]. Materials Reports, 2018, 32(3): 362 -367 .
[3]	Qingshun GUAN,Jian LI,Ruyuan SONG,Zhaoyang XU,Weibing WU,Yi JING,Hongqi DAI,Guigan FANG. A Survey on Preparation and Application of Aerogels Based on Nanomaterials[J]. Materials Reports, 2018, 32(3): 384 -390 .
[4]	Lijing YANG,Zhengxian LI,Chunliang HUANG,Pei WANG,Jianhua YAO. Producing Hard Material Coatings by Laser-assisted Cold Spray:a Technological Review[J]. Materials Reports, 2018, 32(3): 412 -417 .
[5]	Zhiqiang QIAN,Zhijian WU,Shidong WANG,Huifang ZHANG,Haining LIU,Xiushen YE,Quan LI. Research Progress in Preparation of Superhydrophobic Coatings on Magnesium Alloys and Its Application[J]. Materials Reports, 2018, 32(1): 102 -109 .
[6]	Wen XI,Zheng CHEN,Shi HU. Research Progress of Deformation Induced Localized Solid-state Amorphization in Nanocrystalline Materials[J]. Materials Reports, 2018, 32(1): 116 -121 .
[7]	Xing LIANG, Guohua GAO, Guangming WU. Research Development of Vanadium Oxide Serving as Cathode Materials for Lithium Ion Batteries[J]. Materials Reports, 2018, 32(1): 12 -33 .
[8]	Hao ZHANG,Yongde HUANG,Yue GUO,Qingsong LU. Technological and Process Advances in Robotic Friction Stir Welding[J]. Materials Reports, 2018, 32(1): 128 -134 .
[9]	Laima LUO, Mengyao XU, Xiang ZAN, Xiaoyong ZHU, Ping LI, Jigui CHENG, Yucheng WU. Progress in Irradiation Damage of Tungsten and Tungsten AlloysUnder Different Irradiation Particles[J]. Materials Reports, 2018, 32(1): 41 -46 .
[10]	Fengsen MA,Yan YU,Jie ZHANG,Haibo CHEN. A State-of-the-art Review of Cytotoxicity Evaluation of Biomaterials[J]. Materials Reports, 2018, 32(1): 76 -85 .

Viewed

Full text

Abstract

Cited

Shared

Discussed