生物活性玻璃骨材料力学性能及成骨作用改性的研究进展

材料导报

2019, Vol. 33

Issue (Z2): 553-558

高分子与聚合物基复合材料

生物活性玻璃骨材料力学性能及成骨作用改性的研究进展

杨立¹, 汪鹏生², 张浩¹, 王丰¹, 杨雄刚¹, 冯江涛¹, 华堃池¹, 胡永成³

1 天津医科大学,天津 300070;
2 北京威达峰生物材料有限公司,北京 101102;
3 天津市天津医院,天津 300211

Mechanical Property and Osteogenesis Bioactivity Improvement of BioactiveGlass as Bone Graft Substitutes: a Review

YANG Li¹, WANG Pengsheng², ZHANG Hao¹, WANG Feng¹, YANG Xionggang¹, FENG Jiangtao¹, HUA Kunchi¹,HU Yongcheng³

1 Tianjin Medical University, Tianjin 300070;
2 The Wei Dafeng Biological Materials Company in Beijing, Beijing 101102;
3 Tianjin Hospital, Tianjin 300211

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摘要骨科手术在进行骨缺损修复重建时,往往需要将具有良好生物活性及生物相容性的骨移植材料填充到缺损处,在机体内环境下,骨移植材料发生降解并释放相关生物活性介质,促进成骨细胞增殖、分化,最终诱导并促进骨组织形成。其中生物活性玻璃具有良好的生物活性、生物相容性及可降解性,被广泛应用于牙科、骨科及药物载体等方面,但存在脆性大、易断裂及强度低等不足,限制了其在较大骨缺损及承重骨部位修复中的应用。因此,对生物活性玻璃进行改性已成为材料学研究的方向之一。本文主要从调节玻璃组成、多种材料复合及优化制备工艺等方面,总结了改善生物活性玻璃力学性能及促进成骨作用的方法。

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	杨立
	汪鹏生
	张浩
	王丰
	杨雄刚
	冯江涛
	华堃池
	胡永成

关键词: 生物玻璃玻璃组分复合材料制备工艺溶胶-凝胶法

Abstract: Bone graft materials which can induce and promote the bone regeneration have always been applied to replace damaged parts of the bone. Among these bone graft materials, bioactive glass is one sort of bioactive materials with high biological activity, biocompatibility and biodegradability. However, because of its fragility, breaking tenacity and low mechanical strength compared with normal bone tissue, there remains limitations when applying bioactive glass for repairment of long load-bearing and large area bone defect. And the current article focuses on deve-lopment and perspectives to improve the mechanical property and osteogenesis bioactivity of bioactive glass including regulating the component of it, recombining with other materials and improving the preparation technology.

Key words: bioactive glass glass component composite scaffold preparation technology sol-gel method

出版日期: 2019-11-25 发布日期: 2019-11-25

ZTFLH:

R318

通讯作者: drhuyongcheng@outlook.com

作者简介: 杨立,硕士研究生,师承胡永成教授,研究方向主要为骨肿瘤术后骨缺损的修复与重建,目前以第一作者在相关领域发表文章5篇,其中被SCI收录2篇。
胡永成教授,天津医科大学硕士研究生导师,天津市“131”工程人才,天津医院骨肿瘤科主任。1986年毕业于大连医学院,1995年在解放军进修学院获医学博士学位,2005年赴美国UCSD大学进修一年。胡永成教授致力于骨科事业二十余年,在国内率先开展恶性骨肿瘤新辅助化疗和辅助化疗的应用研究。积极开展脊柱、骨盆、四肢肿瘤术前栓塞、化疗,取得了满意效果,在各种骨肿瘤的诊断及治疗方面积累了丰富的临床经验。发表学术论文172篇,以第一作者被SCI收录的论文11篇,参与主编专著17部,承担并完成国家级、省部级、局级课题20余项,获科研成果奖多项。

引用本文:

杨立, 汪鹏生, 张浩, 王丰, 杨雄刚, 冯江涛, 华堃池, 胡永成. 生物活性玻璃骨材料力学性能及成骨作用改性的研究进展[J]. 材料导报, 2019, 33(Z2): 553-558.
YANG Li, WANG Pengsheng, ZHANG Hao, WANG Feng, YANG Xionggang, FENG Jiangtao, HUA Kunchi,HU Yongcheng. Mechanical Property and Osteogenesis Bioactivity Improvement of BioactiveGlass as Bone Graft Substitutes: a Review. Materials Reports, 2019, 33(Z2): 553-558.

链接本文:

http://www.mater-rep.com/CN/ 或 http://www.mater-rep.com/CN/Y2019/V33/IZ2/553

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