Abstract: Drug burst release phenomenon hinders the development of electrospun drug-loading nanofibers. Electrospun bead-on-string nanofibers can carry drug particles effectively by the beads, which provide a new solution to drug encapsulation. However, the influencing factors of morphology and preparation process of the bead-on-string nanofibers are very complicated and unstable. Therefore, morphology controlling and drug encapsulation properties of the bead-on-string nanofibers become the research hot spot recently. Different structures of the beaded nanofibers are compared and the morphology which can realize drug encapsulation is clarified. The forming mechanisms of the bead-on-string nanofibers are discussed. The influence of solution properties and processing parameters on morphology of the beaded nanofibers is analyzed. Finally, drug encapsulation performance of the bead-on-string nanofibers is introduced.
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