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《材料导报》期刊社  2017, Vol. 31 Issue (21): 54-61    https://doi.org/10.11896/j.issn.1005-023X.2017.021.008
  材料综述 |
多巴胺对骨修复材料表面改性的研究进展
沈佳丽, 石畅, 施冬健, 章朱迎, 陈明清
江南大学化学与材料工程学院,食品胶体与生物技术教育部重点实验室,无锡 214122
Research Progress of Dopamine in Surface Modification of Bone Repair Materials
SHEN Jiali, SHI Chang, SHI Dongjian, ZHANG Zhuying, CHEN Mingqing
Key Laboratory of Food Colloids and Biotechnology of Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122
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摘要 随着骨缺损病患的日益增多,对骨修复材料的要求越来越高,寻求有效的方法使骨修复材料实现功能化,以改善材料与骨组织之间的相互作用及促进骨组织快速修复成了关键所在。海洋生物贻贝分泌的粘附蛋白在水环境中展现出超强粘附性能,能牢固附着于各种材料表面。受粘附蛋白启发,研究发现多巴胺(Dopamine, DA)具有与贻贝粘附蛋白类似的结构和性能,其具有超强粘附性、化学反应活性以及生物相容性;特别是其对骨细胞有优异的粘附、增殖效果,有望用于骨修复材料的表面改性。着重介绍了DA的主要性能以及其在骨修复材料表面改性方面的研究进展。
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沈佳丽
石畅
施冬健
章朱迎
陈明清
关键词:  多巴胺  骨修复材料  表面改性    
Abstract: With the increase of bone defect patients, requirements of bone repair materials become higher and higher. It is important to seek effective modification methods to prepare functional bone repair materials for improving the interaction between materials and the bone tissue and promoting bone repair rapidly. Inspired by the strong adhesive proteins secreted by mussels for attachment onto various substrates in wet condition, some research indicated that dopamine (DA) possesses the similar structure and performance to mussel adhesion proteins. Because of the strong adhesion, chemical reactivity and biocompatibility of DA, it is expected to be used for bone repair materials surface modification. This paper introduces the main performance and its research progress in surface modification of bone repair materials.
Key words:  dopamine    bone repair materials    surface modification
出版日期:  2017-11-10      发布日期:  2018-05-08
ZTFLH:  O632  
通讯作者:  施冬健,女,副教授,主要从事功能高分子材料和纳米材料的制备、性能与应用研究,以及可降解生物医用材料的结构设计与药物控制释放行为的研究 E-mail:djshi@jiangnan.edu.cn   
作者简介:  沈佳丽:女,1992年生,硕士研究生,主要从事生物基骨修复复合材料的研究
引用本文:    
沈佳丽, 石畅, 施冬健, 章朱迎, 陈明清. 多巴胺对骨修复材料表面改性的研究进展[J]. 《材料导报》期刊社, 2017, 31(21): 54-61.
SHEN Jiali, SHI Chang, SHI Dongjian, ZHANG Zhuying, CHEN Mingqing. Research Progress of Dopamine in Surface Modification of Bone Repair Materials. Materials Reports, 2017, 31(21): 54-61.
链接本文:  
https://www.mater-rep.com/CN/10.11896/j.issn.1005-023X.2017.021.008  或          https://www.mater-rep.com/CN/Y2017/V31/I21/54
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