刺激响应性聚氨基酸材料的设计与应用

doi:10.11896/cldb.24080169

材料导报

2025, Vol. 39

Issue (5): 24080169-13 https://doi.org/10.11896/cldb.24080169

新型生物医用材料

刺激响应性聚氨基酸材料的设计与应用

王宛滢^†, 李宁^†, 宋子元^*

苏州大学功能纳米与软物质研究院,江苏省碳基功能材料与器件高技术研究重点实验室,江苏苏州 215123

Design and Application of Stimulus-responsive Polypeptide Materials

WANG Wanying^†, LI Ning^†, SONG Ziyuan^*

Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, Jiangsu, China

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摘要由氨基酸N-羧酸环内酸酐开环聚合得到的聚氨基酸材料是一类重要的生物医用材料。通过功能化单体和聚合后修饰的设计,能够赋予聚氨基酸材料针对内源性和外源性刺激的响应性,使其能够特异性地对组织微环境做出结构响应,实现偶联或包载药物的选择性释放。因此,刺激响应性聚氨基酸材料在药物递送、组织工程、免疫调节和抗菌等生物医学领域具有广泛应用。迄今为止,国内外学者们通过合理的聚氨基酸材料结构设计,实现了针对不同刺激、多种模式的载药纳米颗粒的结构改变,并成功将其应用到癌症等疾病的诊疗中。本综述从聚氨基酸的刺激响应化学出发,总结归纳了不同生理环境下不同模式的纳米药物设计及其在生物医学领域的应用,并对刺激响应性聚氨基酸材料领域的发展提出了自己的理解。

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	王宛滢
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关键词: 聚氨基酸氨基酸N-羧酸环内酸酐刺激响应性生物医学应用

Abstract: Polypeptide materials, obtained by ring-opening polymerization (ROP) of amino acid N-carboxyanhydrides (NCAs), are an important class of biomedical materials. Through the design of functional monomers and post-polymerization modifications, polypeptide materials are able to respond to endogenous or exogenous stimuli through structural changes under specific microenvironment, thus selectively releasing the conjugated or encapsulated drugs on demand. Therefore, stimulus-responsive polypeptide materials have a wide range of studies in various biomedical fields such as drug delivery, tissue engineering, immune regulation, and antibacterial applications. Researchers have devoted numerous efforts to the design of stimulus-responsive polypeptide materials for the treatment of cancer and other diseases, aiming to enable versatile structural changes to specific stimuli. Herein we reviewed the development of stimulus-responsive chemistry in polypeptides, summarized the versatile designs of polypeptide-based nanomedicines, and highlighted their biomedical applications. The comments on the future development of stimulus-responsive polypeptides were incorporated at the end of our review.

Key words: polypeptides amino acid N-carboxyanhydrides stimulus responsiveness biomedical application

出版日期: 2025-03-10 发布日期: 2025-03-18

ZTFLH:

TB34

基金资助: 国家自然科学基金(22101194);江苏省自然科学基金(BK20210733);苏州市科技计划项目(ZXL2021447)

通讯作者: ^*宋子元,博士,苏州大学功能纳米与软物质研究院教授、博士研究生导师。主要从事聚氨基酸的合成方法学、聚合机理、二级结构调控和生物医学应用方向的研究。zysong@suda.edu.cn

作者简介: 王宛滢,苏州大学功能纳米与软物质研究院博士研究生,在宋子元教授的指导下进行研究。目前主要研究方向为聚氨基酸材料在急性髓系白血病治疗中的应用。
李宁,苏州大学功能纳米与软物质研究院博士研究生,在宋子元教授的指导下进行研究。目前主要研究方向为共聚氨基酸纳米颗粒表面化学调控和体内命运。^†共同第一作者

引用本文:

王宛滢, 李宁, 宋子元. 刺激响应性聚氨基酸材料的设计与应用[J]. 材料导报, 2025, 39(5): 24080169-13.
WANG Wanying, LI Ning, SONG Ziyuan. Design and Application of Stimulus-responsive Polypeptide Materials. Materials Reports, 2025, 39(5): 24080169-13.

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https://www.mater-rep.com/CN/10.11896/cldb.24080169 或 https://www.mater-rep.com/CN/Y2025/V39/I5/24080169

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