生物医用锆基合金的研究进展

doi:10.11896/cldb.24020141

材料导报

2025, Vol. 39

Issue (5): 24020141-10 https://doi.org/10.11896/cldb.24020141

新型生物医用材料

生物医用锆基合金的研究进展

林家茂, 姚美意^*, 陈哲斌, 徐诗彤, 胡丽娟

上海大学材料研究所,上海 200072

Research Progress of Zirconium-based Biomedical Alloys

LIN Jiamao, YAO Meiyi^*, CHEN Zhebin, XU Shitong, HU Lijuan

Institute of Materials, Shanghai University, Shanghai 200072, China

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摘要锆基生物医用合金材料因弹性模量低、强度高、在生理环境中耐腐蚀性能好、生物相容性好等优点逐渐引起人们的关注,被用作人体硬组织替代材料。本文综述了目前Zr-Nb系、Zr-Mo系及Zr-Ti系医用锆合金的研究进展;基于生物医用材料的性能要求,概括了合金成分对医用锆合金力学性能、耐腐蚀性能、生物相容性等的影响。此外,表面改性技术是提高合金表面性能的重要手段,本文从不同的技术和功能涂层方面入手,综述了锆合金表面改性在生物医学领域的研究进展。最后,对生物医用锆合金及其表面改性技术的发展方向进行了展望,以期为生物医用锆合金的研发提供有价值的参考。

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关键词: 生物医用材料锆合金表面改性性能

Abstract: Zirconium-based biomedical alloys have attracted more and more attention due to their low elastic modulus, high strength, good corrosion resistance and biocompatibility in physiological environment, and have been exploratorily used as human hard tissue replacement materials. This paper reviews the research progress of medical zirconium alloys in Zr-Nb, Zr-Mo and Zr-Ti systems, then summarizes the influence of alloy composition on the mechanical properties, corrosion resistance and biocompatibility of medical zirconium alloys based on the performance requirements of biomedical materials. In addition, surface modification technology is an important means to improve the surface properties of alloys. The research progress of surface modification of zirconium alloys in the biomedical field is reviewed from the aspects of different technologies and functional coatings. Finally, the development direction of biomedical zirconium alloy and its surface modification technology is prospected, hoping to provide valuable reference for the research and development of biomedical zirconium alloys.

Key words: biomedical material zirconium alloy surface modification property

出版日期: 2025-03-10 发布日期: 2025-03-18

ZTFLH:

TG146.414

通讯作者: ^*姚美意,上海大学材料科学与工程学院研究员、博士研究生导师。目前主要从事核燃料包壳材料锆合金、耐事故容错燃料(ATF)包壳材料、生物医用锆合金等方面的研究工作。yaomeiyi@shu.edu.cn

作者简介: 林家茂,上海大学材料科学与工程学院硕士研究生,在姚美意老师的指导下进行研究。目前主要研究领域为生物医用锆合金。

引用本文:

林家茂, 姚美意, 陈哲斌, 徐诗彤, 胡丽娟. 生物医用锆基合金的研究进展[J]. 材料导报, 2025, 39(5): 24020141-10.
LIN Jiamao, YAO Meiyi, CHEN Zhebin, XU Shitong, HU Lijuan. Research Progress of Zirconium-based Biomedical Alloys. Materials Reports, 2025, 39(5): 24020141-10.

链接本文:

https://www.mater-rep.com/CN/10.11896/cldb.24020141 或 https://www.mater-rep.com/CN/Y2025/V39/I5/24020141

1 Li C L, Zhan Y Z, Jiang W P. Materials & Design, 2011, 32, 4598.
2 Sumita M, Hanawa T, Ohnishi I, et al. Comprehensive Structural Integrity, 2003, 4, 131.
3 Wang C T, Ge S R, Jin Z M. The engineering of orthopedics implants, Shanghai Jiao Tong University Press, China, 2016, pp.355 (in Chinese).
王成焘, 葛世荣, 靳忠民. 骨科植入物工程学, 上海交通大学出版社, 2016, pp.355.
4 Ren J S, Zhang Y M, Tan J, et al. Materials Reports, 2016, 30(S2), 384 (in Chinese).
任军帅, 张英明, 谭江, 等. 材料导报, 2016, 30(S2), 384.
5 Wei C X, Luo L Y, Wu Z X, et al. Journal of the Mechanical Behavior of Biomedical Materials, 2020, 111, 104017.
6 Okazaki Y, Sethumadhvan R, Yoshimasa I, et al. Biomaterials, 1998, 19(13), 1197.
7 Lopez M F, Jimenez J A, Gutierrez A. Electrochimica Acta, 2003, 48(10), 1395.
8 Sumner D R, Turner T M, Igloria R, et al. Journal of Biomechanics, 1998, 31, 909.
9 Geetha M, Singh A K, Asokamani R, et al. Progress in Materials Science, 2009, 54, 397.
10 Okazaki Y. Biomaterials, 2002, 23, 2071.
11 Suzuki A K, Campo K N, Fonseca E B, et al. Scientific Reports, 2020, 10, 2621.
12 Yoshiaki I, Kazuhiro T, Equo K, et al. Materials Transactions, 2005, 46, 2260.
13 Hobbs L W, Rosen V B, Mangin S P, et al. International Journal of Applied Ceramic Technology, 2005, 2(3), 221.
14 Zhou F Y, Qiu K J, Li H F, et al. Acta Biomaterialia, 2013, 9(12), 9578.
15 Liu J Z. Nuclear structural materials, Chemical Industry Press, China, 2007, pp.192 (in Chinese).
刘建章. 核结构材料, 化学工业出版社, 2007, pp.192.
16 Kobayashi E, Doi H, Yoneyama T, et al. Journal of the Japanese Society for Dental Materials and Devices, 1995, 14(3), 321.
17 Zhang Y M, Guo T W, Li Z C. West China Journal of Stomatology, 1999, 17(4), 329 (in Chinese).
张玉梅, 郭天文, 李佐臣. 华西口腔医学杂志, 1999, 17(4), 329.
18 Grandin H M, Berner S, Dard M. Materials, 2012, 5(8), 1348.
19 Al-Nawas B, Bragger U, Meijer H J, et al. Clinical Implant Dentistry and Related Research, 2012, 14(6), 896.
20 Barter S, Stone P, Bragger U. Clinical Oral Implants Research, 2012, 23, 873.
21 Chiapasco M, Casentini P, Zaniboni M, et al. Clinical Oral Implants Research, 2012, 23(10), 1136.
22 Guglielmotti M B, Renou S J, Cabrini R L. International Journal of Oral & Maxillofacial Implants, 1999, 14(4), 565.
23 Tsutsumi Y, Nishimura D, Doi H, et al. Materials Science & Engineering C, 2009, 29(5), 1702.
24 Branzoi I V, Iordoc M, Branzoi F. Key Engineering Materials, 2009, 415, 13.
25 Nomura N, Tanaka Y, Suyalatu, et al. Materials Transactions, 2009, 50(10), 2466.
26 Kondo R, Nomura N, Suyalatu, et al. Acta Biomaterialia, 2011, 7, 4278.
27 Zhou F Y, Wang B L, Qiu K J, et al. Materials Science & Engineering C, 2012, 32, 851.
28 Kondo R, Shimizu R, Naoyuki N, et al. Acta Biomaterialia, 2013, 9, 5795.
29 Zhao X L, Li L, Niinomi M, et al. Acta Biomaterialia, 2017, 62, 372.
30 Nie L, Zhan Y Z, Hu T, et al. Journal of the Mechanical Behavior of Biomedical Materials, 2014, 29, 1.
31 Xue R H, Wang D, Yang D W, et al. Materials, 2013, 13, 5130.
32 Wang M K, Yuan J H, Liu Y F, et al. Acta Metallurgica Sinica, 2021, 57(1), 95 (in Chinese).
王明康, 苑峻豪, 刘宇峰, 等. 金属学报, 2021, 57(1), 95.
33 Rosalbino F, Maccio D, Giannoni P, et al. Journal of Materials Science:Materials in Medicine, 2011, 22, 1293.
34 Liang J S, Liu L B, Xu G L, et al. Calphad, 2017, 56, 196.
35 Suyalatu, Nomura N, Oya K, et al. Acta Biomaterialia, 2010, 6(3), 1033.
36 Suyalatu, Kondo R, Tsutsumi Y, et al. Acta Biomaterialia, 2011, 7, 4259.
37 Zhou F Y, Wang B L, Qiu K J, et al. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2013, 101B(2), 237.
38 Nie L, Zhan Y Z, Liu H, et al. Materials & Design, 2014, 53, 8.
39 Guo S, Shang Y, Zhang J S, et al. Journal of Alloys and Compounds, 2018, 754, 232.
40 Hsu H C, Wu S C, Sung Y C, et al. Journal of Alloys and Compounds, 2009, 488, 279.
41 Wei C X, Luo L Y, Wu Z X, et al. Journal of the Mechanical Behavior of Biomedical Materials, 2020, 111, 104017.
42 Wang D, Liu L B, Xue R H. Materials Science and Engineering of Powder, 2021, 26(2), 125 (in Chinese).
王东, 刘立斌, 薛人豪, 等. 粉末冶金材料科学与工程, 2021, 26(2), 125.
43 Kim T I, Han J H, Lee I S, et al. Bio-medical Materials and Engineering, 1997, 7(4), 253.
44 Shibutani H, Morinaga M, Kikuchi K. Atomic Energy Society of Japan, 1998, 40(1), 70.
45 Afrin M, Song T, Wei X, et al. Advanced Engineering Materials, 2018, 20(9), 1800207.
46 Bachtar F, Chen X, Hisada T. Medical & Biological Engineering & Computing, 2006, 44, 643.
47 Frost H M. The Angle Orthodontist, 2004, 74(1), 3.
48 Lyu J, Cheng J, Hou X B. Introduction to biomaterials, Tongji University Press, China, 2016, pp.23 (in Chinese).
吕杰, 程静, 侯晓蓓. 生物医用材料导论, 同济大学出版社, 2016, pp.23.
49 Kuncicka L, Kocich R, Lowe T C. Progress in Materials Science, 2017, 88, 232.
50 Kim M, An S, Huh C, et al. Applied Sciences, 2019, 9, 5281.
51 Chui P F. Vacuum, 2017, 143, 54.
52 Zhou F Y, Qiu K J, Bian D, et al. Journal of Materials Science & Technology, 2014, 30(4), 299.
53 Nie L, Zhan Y Z, Liu H, et al. Materials Science & Engineering C, 2013, 33, 5105.
54 Guo S, Zhang J M, Shang Y, et al. Journal of Alloys and Compounds, 2018, 745, 234.
55 Xue G L, Yang H L, Xing H X, et al. Journal of Central South University, 2020, 27, 2185.
56 Gu Q S, Hou C L, Xu Z. Practical biomedical materials science, Shanghai Science and Technology Press, China, 2005, pp.182 (in Chinese).
顾其胜, 侯春林, 徐政. 实用生物医用材料学, 上海科学技术出版社, 2005, pp.182.
57 Zhou F Y, Wang B L, Qiu K J, et al. Applied Surface Science, 2013, 265, 878.
58 Zhang J F, Gan X X, Tang H Q, et al. Materials Science & Engineering C, 2017, 76, 260.
59 Liu D Y, Zhan Y Z. Guangxi Sciences, 2018, 25(6), 633 (in Chinese).
刘东云, 湛永钟. 广西科学, 2018, 25(6), 633.
60 Niinomi M. The Journal of the Minerals, Metals & Materials Society, 1989, 51(6), 32.
61 Biesiekierski A, Wang J, Gepreel M, et al. Acta Biomaterialia, 2012, 8, 1661.
62 Chen Q Z, Thouas G A. Materials Science & Engineering R-Reports, 2015, 87, 1.
63 Oldani C, Dominguez A. Recent Advances in Arthroplasty, 2012, 218, 149.
64 Niinomi M, Nakai M, Hieda J. Acta Biomaterialia, 2012, 8(11), 3888.
65 Calin M, Gebert A, Ghinea A C, et al. Materials Science & Engineering C, 2013, 33, 875.
66 Zhang E L, Zhao X T, Hu J L, et al. Bioactive Materials, 2021, 6(8), 2569.
67 Mahmoudi P, Akbarpour M R, Lakeh H B, et al. Materials Today Bio, 2022, 17, 100447.
68 Yu J Y, Yang X X, Zhan D S, et al. Chinese Journal of Materials Research, 2021, 35(11), 873 (in Chinese).
于佳莹, 杨希祥, 战德松, 等. 材料研究学报, 2021, 35(11), 873.
69 Taipina M O, Mello M G, Tamborlin L, et al. Materials Chemistry and Physics, 2021, 261, 124192.
70 Fu S, Zhang Y, Yang Y, et al. Journal of Materials Science & Technology, 2022, 119, 75.
71 Bui F M, Bott K, Mintchev M P. Journal of Medical Engineering & Technology, 2000, 24(1), 20.
72 Collings E W. Metallurgical and Materials Transactions A, 1979, 10A, 463.
73 Mattei L, Di Puccio F, Piccigallo B, et al. Tribology International, 2011, 44, 532.
74 Gremillard L, Martin L, Zych L, et al. Acta Biomaterialia, 2013, 9, 7545.
75 Luo Y, Yang T, Rao X, et al. International Journal of Advanced Manufacturing Technology, 2018, 96, 1539.
76 Alipal J, Mohd P N, Nayan N, et al. Materials Today:Proceedings, 2021, 42(1), 270.
77 Liu Y Y, Yang Y L, Dong D Y, et al. Journal of Engineering, 2020, 20, 100638.
78 Li L, Yao S L, Zhao X L, et al. Acta Metallurgica Sinica, 2019, 55(8), 1008 (in Chinese).
李玲, 姚生莲, 赵晓丽, 等. 金属学报, 2019, 55(8), 1008.
79 Farina S B, Sanchez A G, Cere S. Procedia Materials Science, 2015, 8, 1166.
80 Wang S, Guo F, Bai H R, et al. Rare Metal Materials and Engineering, 2010, 39(4), 739 (in Chinese).
王双, 郭锋, 白海瑞, 等. 稀有金属材料与工程, 2010, 39(4), 739.
81 Chen Y, Nie X, Northwood D O. Surface & Coatings Technology, 2010, 205(6), 1774.
82 Reger N C, Balla V K, Das M, et al. Surface & Coatings Technology, 2018, 334, 357.
83 Mordyuk B N, Karasevskaya O P, Prokopenko G I. Materials Science & Engineering A, 2013, 559, 453.
84 Ratner B D, Hoffman A S, Schoen F J, et al. Biomaterials science:an introduction to materials in medicine, Elsevier Press, Netherlands, 2004, pp.537.
85 Good V, Ries M, Barrack R L, et al. Journal of Bone & Joint Surgery, 2003, 85, 105.
86 Good V, Widding K, Hunter G, et al. Materials in Engineering, 2005, 26(7), 618.
87 Kim Y H. Journal of Bone & Joint Surgery, 2005, 87(8), 1769.
88 Reger N C, Vamsi K B, Mitun D, et al. Surface & Coatings Technology, 2018, 334, 357.
89 Brunski J B. Clinical Materials, 1992, 10, 153.
90 Bai X H, Fan L, Zhao M Y, et al. Titanium Industry Progress, 2022, 39(3), 33 (in Chinese).
白雪寒, 范林, 赵铭钰, 等. 钛工业进展, 2022, 39(3), 33.
91 Hsu H C, Wu S C, Yang C H, et al. Journal of Materials Science: Materials in Medicine, 2009, 20, 615.
92 Singh S, Prakash C, Singh H. Surface & Coatings Technology, 2020, 398, 126072.
93 Rafieerad A R, Bushroa A R, Nasiri-Tabrizi B, et al. Advances in Applied Ceramics, 2017, 116(6), 293.

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