A Novel Injectable KGM/Fiber Composite Bone Cement for Bone Defect
IU Hanwu1,, ZHAO Qiang2,, XIAO Ting3,, YAN Tingting1
1 School of Materials Science and Engineering,Kunming University of Science and Technology,Kunming 650093,China 2 Department of Stomatology,920 Hospital of Joint Logistics Support Force,PLA,Kunming 650032,China 3 School of Dental Medicine,Hunan University of Chinese Medicine,Changsha 410208,China
Abstract: The injection of bone cement is a promising surgical intervention for the treatment of osteoporosis.The aim of this study was to formulate a novel injectable bioactive bone cement to adress such medical problems.The bone cement primarily consists of tricalcium phosphate (β-TCP),konjac glucomannan (KGM),and hydroxyapatite whisker (HAw).An orthogonal experiment was designed to generate multiple sets of new composite calcium phosphate cement (NCPC) samples,and their setting times were measured.The in vitro compatibility of the new bone cement was assessed through relative cell proliferation rate (RGR) and in vitro cell growth experiments.Mechanical strength and porosity tests were conducted for each group of bone cement,and cross-sectional morphology was observed.The results demonstrate that the bone cement exhibits favorable properties such as self-curing,mechanical robustness,and resistance to collapse. The optimum formulation involves a doping ratio of 5/15(wt%) HAw and HA,an additional amount of 1.2wt% KGM,and a liquid citric acid concentration of 2wt%.Porosity tests confirmed that the material has high compressive strength and a favorable porosity of 27%,creating conducive conditions for cell growth,proliferation,and material degradation.Moreover,in vitro cell culture experiments revealed excellent biocompatibility of the material.Consequently,the developed NCPC emerges as a potential candidate material for applications of bone implantation.
通讯作者:
*Tingting Yan,Doctor,Professor.Team leader of Biological Functional materials,Kunming University of Science and Technology.His research interests cover the development and application of materials for bone repair,cartilage repair and skin repair.itty@foxmail.com
作者简介: ?共同第一作者Hanwu Liu,received Bachelor of Engineering degree from University of Jinan in June 2021.Currently,as a postgraduate student in the School of Materials Science and Engineering,Kunming University of Science and Technology,conducting research under the guidance of Professor Yan Tingting.At present,the main research area is biological functional materials.
引用本文:
刘汉武, 赵强, 肖婷, 颜廷亭. 一种新型可注射KGM/纤维复合骨水泥治疗骨缺损[J]. 材料导报, 2025, 39(19): 24070058-8.
IU Hanwu, ZHAO Qiang, XIAO Ting, YAN Tingting1. A Novel Injectable KGM/Fiber Composite Bone Cement for Bone Defect. Materials Reports, 2025, 39(19): 24070058-8.
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