碳基及氧化锌量子点在癌症诊疗应用中的研究进展

doi:10.11896/cldb.19040038

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Abstract Cancer is a dynamic and heterogeneous disease with high mortality and high morbidity. In the treatment of cancer, chemotherapy is consi-dered to be one of the most effective means. While conventional chemotherapy has some defects such as multidrug resistance, highly toxic, rapid elimination of chemotherapy drugs by metabolism, drug inactivation, and it may accumulate at non-specific sites to cause damage to normal cells and tissues. Advances in drug delivery technology and nanotechnology have allowed new formulations of drugs to improve pharmacokinetics, enhance accumulation in solid tumors, and reduce the significant toxic side effects of these important therapeutic agents.
Intracellular drug delivery to tumor cells and cell imaging is critical for the clinical treatment of malignant tumors. Therefore, there is a need for effective drug delivery and cell imaging systems. Cancer nanotechnology is an emerging field of cancer diagnosis and treatment. Although significant progress has been made in delivering targeted anti-cancer agents to specific sites of interest, new nanomaterials are often developed and explored to achieve higher drug delivery efficiencies.
Efficient targeted delivery of drugs is critical for cancer treatment. With advances in drug delivery technology and nanotechnology, many efficient drug delivery systems have been developed with nanotechnology, providing a versatile platform for simultaneous therapeutic and diagnostic (diagnostic) functions. In recent years, quantum dots have become more and more widely used for cell targeting, imaging, and drug delivery due to their unique optical and physicochemical properties.
This review discusses the recent advances in the use of biocompatible graphene quantum dots, carbon quantum dots, and zinc oxide quantum dots as carriers for anticancer drugs. And the cytotoxicity, fluorescence imaging, smart delivery, and synergistic treatment of these quantum dots in the application of multifunctional parts is summarized. At last, we list the challenges of practical application as a therapeutic drug carrier.

Key words： quantum dots biocompatibility biological imaging synergistic treatment drug delivery system

Published: 27 April 2020

CLC number:

TB34

Fund:This work was financially supported by the National Natural Science Foundation of China (21502166), the 10th Research Innovation Project of Yunnan University (2018211).

About author:: Junming Zhu graduated from Northeast Petroleum University with a B.S. degree in engineering in June 2013. In September of the same year, he entered the School of Materials Science and Engineering of Yunnan University to pursue a master’s degree in materials processing engineering under the supervision of Prof. Qingmei Yuan. His research has focused on the application of graphene quantum dots in cancer diagnosis and treatment.
Qingmei Yuan, an associate professor and master tutor in the School of Materials Science and Engineering, Yunnan University. She received her B.S., M.S., and Ph.D. degrees in Oganic Chemistry from Yunnan University in 1998, 2001 and 2012 respectively. Since 2001, she has been working at Yunnan University, and from June 2016 to July 2017, she worked as a visiting scholar in the Department of Biochemistry and Molecular Biology of the Pennsylvania State University. Recently, she has presided over 1 National Natural Science Foundation of China and 2 Natural Science Foundation of Yunnan Province. Her research interests mainly focus on the design and synthesis of drug carriers and their applications in the diagnosis and treatment of cancer and other diseases.

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	ZHU Junming
	DONG Liang
	QIN Zhen
	LI Zhennan
	YUAN Qingmei

Cite this article:

ZHU Junming,DONG Liang,QIN Zhen, et al. Research Progress of Carbon-based and Zinc Oxide Quantum Dots in Cancer Diagnosis and Treatment[J]. Materials Reports, 2020, 34(9): 9075-9085.

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http://www.mater-rep.com/EN/10.11896/cldb.19040038 OR http://www.mater-rep.com/EN/Y2020/V34/I9/9075

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