生物陶瓷支架促进再生组织血管生成和骨生成的研究进展

doi:10.11896/cldb.20050019

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Abstract Tissue engineering has acquired remarkable attention as a promising strategy to treat and restore bone defects during recent years. A scaffold is a fundamental component for tissue engineering, which provides a necessary support and guidance for bone tissue regeneration. It is necessary to form a vascular network inside the scaffold to provide nutrients and oxygen for cells to migrate, proliferate and differentiate, and then realize tissue regeneration in the process of bone tissue repair. Consequently, the vascularization is the first requirement to achieve bone tissue regeneration. Bioceramics have become competetive candidates as scaffold materials for bone tissue regeneration due to the special chemical composition, high compressive strength and excellent bioactivity.
However, a vascular networks formed in the bioceramic scaffolds will take a long time after implantation in vivo, meaning that cells in the middle of the tissue will be straved of nutrients for a long time and then die. This urges intensive research works to study the effect of material, structure and environmental factors of the bioceramic scaffolds on the osteogenesis and vasculature, aiming at achieving better tissue regeneration.
The composites can not only improve the mechanical properties of the scaffold, but also improve the biological activity of the scaffold. Designing hierarchical porous structure and loading growth factors can better stimulate angiogenesis and osteogenesis of the regenerated tissue. These aspects can be considered in combination to promote the angiogenesis and osteogenesis of the bioceramic scaffolds.
This review summarizes the factors affecting angiogenesis and osteogenesis of regenerated tissues in the bioceramic scaffolds from three aspects: scaffold material, scaffold structure and environmental factors of the scaffold. Meanwhile, the influence mechanisms of the above factors are systematically analyzed. Finally, the development trend of the bioceramic scaffolds is prospected expecting to provide references for the design, processing and bioengineering applications of the bioceramics.

Key words： bioceramic scaffolds tissue engineering angiogenesis osteogenesis

Published: 19 January 2021

CLC number:

TQ174

Fund:This work was financially supported by the National Key R&D Program of China (2017YFB1103500, 2018YFB1106600), National Natural Science Foundation of China (51822405), Key R&D Program of Shaanxi Province (2018ZDCXL-GY-09-04), Research Fund of the State Key Laboratory of Solidification Processing (2019-QZ-02).

About author:: Guangrao Fan received her B.E. degree in college of materials science and engineering from Taiyuan University of Technology in 2016. She is currently pursuing her Ph.D. at the State Key Laboratory of Solidification Processing (SKL), Northwestern Polytechnical University, under the supervision of Prof. Jun Zhang and Prof. Haijun Su. Her research direction is mainly focused on directionally solidified eutectic bioceramic.
Haijun Su, professor of the School of Materials Science and Engineering, Northwestern Polytechnical University. He is the winner of the National Natural Science Foundation for Excellent Youth Scholars, Hong Kong Scholars, Shaanxi Provincial Youth Science and Techo-logy Star, and academic leader of the Youth Innovation Team in Shaanxi Universities. His research interests are mainlyfoucsed on the design, preparation and application of advanced biocomposite ceramics. He has undertook or completed more than 20 national, provincial and ministerial scientific research projects including 4 National Natural Science Foundation of China. More than 100 SCI papers have been published in international academic journals such as Small, ACS Applied Materials and Interfaces, Journal of the European Ceramic Society. He has been authorized 26 Chinese invention patents and 1 American invention patent. He has won the first prize of Shaanxi Provincial Science and Technology Award and Shaanxi Provincial Youth Science and Technology Award.

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	FAN Guangrao
	SU Haijun
	GUO Min
	ZHANG Jun
	GAO Jialiang
	HAO Xuancheng
	SONG Qiang
	LIU Lin
	FU Hengzhi

Cite this article:

FAN Guangrao,SU Haijun,GUO Min, et al. Research Progress on Bioceramics Scaffolds in Promoting Angiogenesis and Osteogenesis in Regenerated Tissues[J]. Materials Reports, 2021, 35(1): 1096-1104.

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http://www.mater-rep.com/EN/10.11896/cldb.20050019 OR http://www.mater-rep.com/EN/Y2021/V35/I1/1096

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