丝素蛋白基纺织材料及其在生物医学领域的应用

doi:10.11896/cldb.19040294

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Abstract Silk fibroin (SF) is a natural protein polymer that can be extracted from B. mori silkworm cocoons. It has been used by the textile industry for thousands of years. With increasing needs for implantable and degradable biomaterials, SF textile material has attracted more and more interests in the biomedical field, due to its excellent biocompatibility, biodegradability, non-immunogenicity and sufficient supply. Moreover, it can be combined with other biomaterials to form biopolymer composites with unique performance. The versatility and sustainability of SF fibers-based biomedical textile material provides new research ideas and solutions for tailoring biomaterials to meet specific biomedical applications via eco-friendly approaches.
The natural SF fiber can be obtained by degumming the cocoons, and after being dissolved, the regenerated SF solution can be obtained. Then, the regenerated SF solution can further prepare the regenerated SF fiber by different molding methods. According to the practical application requirements in the field of biomedicine, SF fibers can be made into one-dimensional, two-dimensional or three-dimensional biomedical textiles by various techniques such as weaving, knitting, non-woven, electrospinning and three-dimensional printing technology, which have broad application prospects in biomedical fields such as tissue engineering, drug delivery and biosensors. However, there are still some disadvantages in the mechanical properties and persistence of SF textile materials, beyond that the specific biofunctionality is not excellent such as blood solubility, cell adhesion, osseointegration and cell differentiation. Therefore, the application of silk fibroin textile materials in the biomedical field is limited to some extent.
In order to expand the application of SF textile materials in the biomedical field, it is usually necessary to enhance the inherent function or introduce new functions of SF textile materials through functional modification while retaining its intrinsic properties. At present, there are four main methods for functional modification of SF materials, including intrinsic functional modification, surface modification of SF fiber, blending modification with other functional fiber, directly mixing before regenerated SF solution spinning. The functionally modified SF materials can effectively guide cell response and functional expression, enhance mechanical properties, and achieve the purpose of promoting wound healing and tissue organ repair.
This paper mainly reviews the recent advances in the development of one-dimensional, two-dimensional and three-dimensional SF-based textile materials in the biomedical fields. And the structure and basic properties of SF materials are introduced, the functional modification methods of SF-based textile materials are summarized. Besides, the future development tendency of SF-based textile materials is also forecasted.

Key words： silk fibroin textile materials biomedical tissue engineering

Published: 10 April 2020

CLC number:

TS102.3

Fund:This work was financially supported by National Key R&D Program of China (2016YFC1100100), Natural Science Foundation of Jiangsu Province of China (BK20161253), Nantong Science and Technology Planning Project (GY12017008), Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

About author:: Fengjiao Baiis currently pursuing her M.D. at the College of Textile and Clothing Engineering, Soochow University under the supervision of Prof. Hui Wang. Her research has focused on silk fibroin biomaterials.
Hui Wangreceived her B.S. degree in Chemistry and Ph.D. degrees in Physical Chemistry from Xiamen University in 2003 and 2009 respectively. After two-year postdoctoral research at National University of Singapore, she is currently a full associate in Soochow University. Her research interests focus on nano- and micro scale structural biomimetic biomaterials, including biomineralization, synthesis and Functionalization of silk fibroin materials and organic-inorganic composite materials, surface micropatterning modification.
Keqin Zhangreceived his B.E. degree in Physics from Nanjing University in 1994 and received his Ph.D. degree in Physics from Nanjing University in 2000. He conducted his postdoctoral training in Max-Planck Institute for Metal Research sponsored by the Max-Planck Postdoctoral Fellowship and National University of Singapore from 2000—2004. He was awarded by the Lee Kuang Yew outstanding postdoctoral fellowship selected by the Lee Kuang Yew foundation from the global applicants at 2005. He became the research fellow and senior research fellow in National University of Singapore from 2004 to 2009. And he was the awardee of the one-thousand-talent recruiting programme issued by the central government of China at 2010. He is the life member of American Physics Society and Biophysics Section, member of Materials Research Society of America and Singapore and member of a council of Chinese Functional Materials Association. His research interests include high performance fiber materials, new functional fiber materials, biomass fibers and biomedical materials

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Cite this article:

BAI Fengjiao,WANG Hui,CHEN Xiaomin, et al. Silk Fibroin-based Textile Materials and Their Application in Biomedical Field[J]. Materials Reports, 2020, 34(7): 7154-7160.

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http://www.mater-rep.com/EN/10.11896/cldb.19040294 OR http://www.mater-rep.com/EN/Y2020/V34/I7/7154

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