角蛋白生物材料在创伤愈合中的应用研究进展

doi:10.11896/cldb.19050214

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Abstract Wound healing is a complex, dynamic, and multistep process which can be affected in different conditions such as the type of wound, pathological conditions, and type of dressing.The ideal wound dressing is characterized by accelerated wound healing, preventing infection, restoration of skin structure and function, fascinating biomaterial and biodegradability and so on. Therefore, the research of wound dressing focus on the development of naturally-derived biomaterials, such as chitosan, gelatin, collagen, silk fibroin, keratin, etc.
Keratin is one of proteins with good biocompatibility and degradability. What’s more, keratin contains cell binding motifs such as leucine-aspartic acid-valine (LDV), glutamic acid-aspartic acid-serine (EDS), and arginine-glycine-aspartic acid (RGD),which imitates the environment of the extracellular matrix to accelerate the adhesion and proliferation of fibroblasts. Furthermore, keratins actively participate in coagulation and aggregation of red blood cells. However, keratin has the disadvantages of brittleness, mechanical properties and poor processing properties. Usually, synthetic or natural polymer materials are added as plasticizers and cross-linking agents to form composite materials to improve these defects, such as polyvinyl alcohol,polylactic acid,chitosan and gelatin. These composite materials have been used to promote healing of wounds.
This review offers a retrospection of the preparation of keratin and its composite hydrogels, scaffolds and membrane materials, and its research on wound healing. Especially skin transforming growth factors, antibacterials(mupirocin), bacteriostatic biomaterials(phenolic acid in natural plants)and antibacterial metal nano-materials (nano-silver, zinc oxide)are loaded into the keratin composite to obtain a multifunctional keratin wound dressing.It is used for acute and/or chronic wounds,such as diabetic foot ulcer, showing a unique advantage due to enhance the antibacterial effect and shortening the inflammation time of the wound. In addition, the prospect of keratin as a biomaterial in the field of medicine is discussed.

Key words： keratin hydrogels spongy porous scaffolds films and fibres wound dressing

Published: 10 April 2020

CLC number:

R914

Fund:The work is financially supported by the National Natural Science Foundation of China (21562014).

About author:: Xiaoxia Sun, received her B.S. degree in pharmacy engineering from Guizhou University in 2017. Now she is a graduate student at Guizhou University,and under the supervision of Prof. Min Yang. Her research has focused on the application of keratin composites in wound healing.
Min Yang received her B.E. degree in organic che-mistry engineering from Guizhou Institute of Technology in 1982, and received her Ph.D. degree in organic chemistry from Sichuan University, in 2006. She is currently a full professor in the School of Pharmaceutical Science, Guizhou University. Her research interests are biomaterials used for wound dressing and hydrogel, drug loading and catalysis of nanoparticle.

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	SUN Xiaoxia
	BAO Yi
	PENG Qianrong
	CHEN Tingyu
	LU Xiaoluan
	YANG Min

Cite this article:

SUN Xiaoxia,BAO Yi,PENG Qianrong, et al. Advances on Application of Keratin Biomaterials in Wound Healing[J]. Materials Reports, 2020, 34(7): 7161-7167.

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http://www.mater-rep.com/EN/10.11896/cldb.19050214 OR http://www.mater-rep.com/EN/Y2020/V34/I7/7161

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