无机抗菌材料抗菌机理研究进展

doi:10.11896/cldb.19090190

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Abstract Since the inorganic materials as antibacterial agents has entered the field of vision, its materials and antibacterial mechanism have been continuously studied and summarized. Inorganic antibacterial materials are mainly divided into metal ion type (such as Ag, Cu, Zn) and metal oxide photocatalytic type (for example TiO₂ and ZnO), its preparation into nano-scale materials, it can better adsorb microorganisms because of the larger specific surface area, so it has better antibacterial effect. At the same time, inorganic antibacterial materials have the advantages of low toxicity, high stability, good durability and not easy to cause bacterial resistance compared with organic antibacterial materials and natural antibacterial materials.
However, in recent years, the antibacterial mechanism of inorganic antibacterial materials has not been systematically analyzed and demonstrated. Most researchers have only proposed the antibacterial mechanism of a metal-type antibacterial material.The antibacterial mechanism of silver system antibacterial materials is more deeply studied in inorganic antibacterial materials. It is generally believed that silver system antibacterial materials release Ag⁺ and adsorbs on the surface of bacteria, then penetrates the cell membrane into the cell to react with the cell contents, and finally leads to the inactivation of bacteria. Whereas metal oxide photocatalytic type (such as TiO₂) antibacterial materials are generally thought to produce a large number of free radicals for instance ·OH, ·O₂^- because their wide optical band gap can produce photocatalytic reactions under the conditions of illumination. When these free radicals are in contact with cells, they react with intracellular organic matter, resulting in bacterial deactivation.
This review offers the antibacterial mechanism of various inorganic materials is summarized and analyzed. According to the antibacterial active substances and objects of action, the antibacterial mechanisms are divided into three types: direct contact type, dissolution-osmotic type and catalytic oxidation type. The current research shows that the three antibacterial mechanisms often exist together and interlaced with each other, and the mechanism analysis is still not thorough. It is suggested that the internal process of antibacterial mechanism should be revealed from the molecular biological and genetic levels for example cell repair and protein conversion.

Key words： inorganic antibacterial materials antibacterial mechanisms reactive oxygen species (ROS)

Published: 19 January 2021

CLC number:

TB34

Fund:This work was financially supported by the Key Projects of Key National R & D Projects (2017YFC0210303);Kunming University of Science and Technology Analysis and Testing Fund(2019M20182208017).

About author:: Xiyan Yao received her B.E. degree from Kunming University of Science and Technology in June 2018. She is currently pursuing her master's degree at the Faculty of Chemical Engineering, Kunming University of Science and Technology under the supervision of asso-ciate professor Xiaoning Tang. Her research has focused on photocatalytic and antibacterial properties of titanium dioxide under visibl light.
Xiaoning Tang received his B.E. degree in chemistry from University of Science and Technology Liaoning in 1998 and received his Ph.D. degree in metallurgy physical and chemistry from the Kunming University of Science and Technology in 2011, he is currently a adjunct professor in Kunming University of Science and Technology.His reseach interests are function materials design and physical chemistry for a long time,therefor published more than 40 papers in the field of material and authorized 5 patents for invention.

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	YAO Xiyan
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Cite this article:

YAO Xiyan,TANG Xiaoning,WANG Xiaonan, et al. Research Progress on Antibacterial Mechanisms of Inorganic Antibacterial Materials[J]. Materials Reports, 2021, 35(1): 1105-1111.

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http://www.mater-rep.com/EN/10.11896/cldb.19090190 OR http://www.mater-rep.com/EN/Y2021/V35/I1/1105

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