金属阳离子掺杂对羟基磷灰石微球性能的影响

doi:10.11896/cldb.20100280

材料导报

2023, Vol. 37

Issue (7): 20100280-7 https://doi.org/10.11896/cldb.20100280

无机非金属及其复合材料

金属阳离子掺杂对羟基磷灰石微球性能的影响

李水源¹, 徐镇宇¹, 李克^1,*, 周奎^1,2,*

1 南昌大学先进制造学院,南昌 330031
2 南昌大学南昌市三维生物制造技术及装备重点实验室,南昌 330031

Effect of Metal Cation Doping on Properties of Hydroxyapatite Microspheres

LI Shuiyuan¹, XU Zhenyu¹, LI Ke^1,*, ZHOU Kui^1,2,*

1 School of Advanced Manufacturing, Nanchang University, Nanchang 330031, China
2 Nanchang Municipal Key Laboratory of 3D Bioprinting Technology and Equipment, Nanchang University, Nanchang 330031, China

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摘要金属离子掺杂能给羟基磷灰石赋予独特的性能,如磁性、抗菌性、骨诱导性等。本工作采用气动挤出打印法制备了毫米级羟基磷灰石-海藻酸钠复合微球,然后用二价金属阳离子(Ca²⁺、Sr²⁺、Cu²⁺、Zn²⁺)交联复合微球并烧结实现金属阳离子的掺杂,详细研究了不同离子掺杂对微球性能(宏微观结构、物理化学性能和生物学性能)的影响。结果表明,不同离子掺杂对羟基磷灰石性能的影响存在一定的差异。四种离子对微球宏观形貌的影响不大,但是铜和锌的存在可促进HA在烧结过程中向β-TCP相的分解,导致微球的降解速率提高。5%Cu-HA-1200和5%Zn-HA-1200微球抑菌率显著高于5%Ca-HA-1200、5%Sr-HA-1200微球。细胞在四种微球表面生长良好。本研究获得的HA/β-TCP双相微球有望在骨缺损修复领域得到应用。

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关键词: 羟基磷灰石金属阳离子掺杂气动挤压打印烧结

Abstract: Metal ion doping can give hydroxyapatite unique properties, such as magnetism, antibacterial property, bone inductivity, etc. The millimeter-scale hydroxyapatite-sodium alginate (HA-SA) composite microspheres were made by pneumatic extrusion printing, and cross-linked by divalent metal cations (Ca, Sr, Cu and Zn). The effect of different ion doping on the properties of microspheres (macro and micro structure, physical and chemical properties, and biological properties) was studied in detail. The results show that there are some differences in the effect of different ion doping on the performance of HA. These four inos have little effect on the macroscopic morphology of the microspheres, but the presence of Cu and Zn promote the decomposition of HA into β-TCP during the sintering process, leading to the increase of the degradation rate of the microspheres. The antibacterial rate of 5% Cu-HA-1200 and 5% Zn-HA-1200 microspheres are significantly higher than 5% Ca-HA-1200 and 5% Sr-HA-1200. HA/β-TCP biphasic spheroid is obtained in this research and these spheroids may be beneficial for bone defect repair.

Key words: hydroxyapatite metal cation doping pneumatic extrusion printing sintering

出版日期: 2023-04-10 发布日期: 2023-04-07

ZTFLH:

TB321

基金资助: 国家自然科学基金(32001017;51665036;31960207)

通讯作者: * 李克,南昌大学教授,博士研究生导师,上海交通大学博士。主要从事金属凝固理论与技术、计算材料学、新能源材料、生物材料方面的研究。发表论文80余篇(其中SCI、EI收录52篇),授权发明专利10项。like.1@126.com
周奎,南昌大学副教授,硕士研究生导师,2012年毕业于武汉大学获学士学位,2016年毕业于华中科技大学获博士学位。长期从事3D打印技术及其在生物医学应用相关的研究,发表研究论文20余篇。zhoukui@ncu.edu.cn

作者简介: 李水源,南昌大学材料加工工程专业18级硕士研究生。研究方向为生物材料的3D打印。

引用本文:

李水源, 徐镇宇, 李克, 周奎. 金属阳离子掺杂对羟基磷灰石微球性能的影响[J]. 材料导报, 2023, 37(7): 20100280-7.
LI Shuiyuan, XU Zhenyu, LI Ke, ZHOU Kui. Effect of Metal Cation Doping on Properties of Hydroxyapatite Microspheres. Materials Reports, 2023, 37(7): 20100280-7.

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http://www.mater-rep.com/CN/10.11896/cldb.20100280 或 http://www.mater-rep.com/CN/Y2023/V37/I7/20100280

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