Abstract: Chloride dissolution of coral sand with 0.03% chloride ion in deionized water, saturated calcium hydroxide solution and cement slurry filtrate was studied, the chloride release from coral sand with different grain size and the effect of artificial grinding on the chloride release from coral sand were studied. It was found that the content of chloride ion decreased in Saturated Calcium hydroxide solution with the increase of soaking time, while the content of chloride ion increased in deionized water and cement slurry filtrate with the increase of soaking time. The amount of chloride ion dissolved from coral sand in deionized water, saturated calcium hydroxide and filtrate of cement slurry was stable after soaking for 14 d,12 h and 12 h, and then the contents of chloride ion in three solvents were 0.032 0%,0.012 8% and 0.013 8% respectively. During the desalination process, the longest dissolution time of chloride ions was 7 d for coral sand grain sizes of ≤0.075 mm and 2.36—4.75 mm particles, while that of other grain sizes was shorter to 2—12 h. The final concentration of chloride ion in coral sand of particle size from 2.36 mm to 4.75 mm was the highest(1.919×10-3 μg/mL),the final chloride ion concentration decreased at first and then increased with the decrease of the maximum particle size of each size fraction. The release time of chloride ion was shortened from 7 d to 2 h, and the concentration of chloride ion was decreased from 1.919×10-3 μg/mL to 0.707×10-3 μg/mL, after the coral sand was ground from 2.36—4.75 mm to 1.18—2.36 mm.