肽类树状大分子的功能化修饰及在肿瘤治疗和诊断中的应用综述

doi:10.11896/cldb.20080149

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Abstract Peptide dendrimers are a three-dimensional nano-sized high-regularity macromolecule with tunable size. In recent years, due to their nume-rous advantages such as biocompatibility, low immunogenicity, multiple functional groups at the periphery and so on, peptide dendrimers have become a novel biomedical polymer material.
Breakthroughs have been made in drug/gene loading, targeted delivery and release by developing great peptide dendrimer-based nanotherapeutics. Anticancer drugs/genes can be either encapsulated in or conjugated to dendrimer and be delivered to the tumor via enhanced permeabi-lity and retention effect (EPR) or with the help of the targeting moiety. Finally, the drugs can be released by the drug delivery systems with more stable and precise therapeutic effect has been extensively studied, while it still remains a challenging issue. In order to achieve more effective antitumor treatment effect, design the more stable, accurate and peptide dendrimer drug delivery system with integrated or combined diagnosis and treatment function is a current research hotspot and difficulty.
In this paper, a brief introduction of surface functionalization progress of peptide dendrimers is presented. Then, their promising application in therapeutic and diagnostic fields as drug carrier is summarized.

Key words： peptide dendrimer functionalization drug targeted delivery cancer therapy cancer diagnosis

Published: Online: 2022-06-09

CLC number:

R318.08

Fund:Natural Science Foundation of Jiangsu Province (BK20180698,BK20180495).

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	Articles by authors
	WANG Pengfei
	XU Shengnan
	WEI Jie
	LIU Wenjuan
	GU Zhongwei
	ZHANG Yanan

Cite this article:

WANG Pengfei,XU Shengnan,WEI Jie, et al. Functionalization of Peptide Dendrimers and Its Application in Tumor Treatment and Diagnosis: a Review[J]. Materials Reports, 2022, 36(11): 20080149-8.

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http://www.mater-rep.com/EN/10.11896/cldb.20080149 OR http://www.mater-rep.com/EN/Y2022/V36/I11/20080149

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