Abstract: Drug resistance as well as cellular proliferation and metastasis of cancer cells may be caused by high-concentration chemotherapeutics leading to the excess secretion of cytokine. In order to clean up those cytokine which could promote proliferation of cancer cells, we have synthesized N-butyl acrylate-4-hydroxybutyl acrylate amphiphilic copolymer to clad docetaxel loaded Fe3O4@ZnO core-shell nanocomposite as a multifunctional drug delivery. It is of great potential for our multifunctional drug delivery to be a targeted drug carrier in vivo because of its good biocompatibility and magnetic responsibility. Most importantly, a controllable drug release as well as epidermal growth factor adsorption behavior could be realized simultaneously by UV radiation in dark. In this way, the inhibition rate to HeLa cells was high than that of raw docetaxel experimental group. Therefore, a new mode of chemotherapy have been developed which have great potential in clinic use.
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2017, Vol. 31 
