修饰纳米CeO2的制备及其复合纤维膜对体外磷活性影响研究

doi:10.11896/cldb.25040225

材料导报

2025, Vol. 39

Issue (21): 25040225-7 https://doi.org/10.11896/cldb.25040225

无机非金属及其复合材料

修饰纳米CeO₂的制备及其复合纤维膜对体外磷活性影响研究

李玉萍¹, 赵青², 章金正¹, 雷晓宇¹, 李丽¹, 木波¹, 杜青达¹, 李玉宝¹, 汪建³, 左奕^1,*

1 四川大学分析测试中心,纳米生物材料研究中心,成都 610064
2 昆明医科大学口腔医学院附属口腔医院,昆明 650500
3 成都理工大学材料与化学化工学院,成都 610059

Fabrication of Modified Nano-CeO₂ and Their Composite Fibrous Membranes for Enhanced Phosphorus Activity: an in vitro Study

LI Yuping¹, ZHAO Qing², ZHANG Jinzheng¹, LEI Xiaoyu¹, LI Li¹, MU Bo¹, DU Qingda¹, LI Yubao¹, WANG Jian³, ZUO Yi^1,*

1 Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, China
2 The Affiliated Hospital of Stomatology, School of Stomatology, Kunming Medical University, Kunming 650500, China
3 College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China

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摘要采用化学沉淀法制备氧化铈纳米颗粒(CeO₂ NPs),并通过柠檬酸钠进行表面修饰(MCeO₂),以改善纳米晶体的分散和酶催化特性。通过透射电子显微镜(TEM)观察其形貌变化,并结合X射线光电子能谱(XPS)和拉曼光谱对Ce³⁺含量及相对氧空位浓度进行半定量分析。结果表明,尽管柠檬酸钠修饰导致Ce³⁺含量和氧空位浓度有所降低,但MCeO₂的催化脱磷活性和分散性均显著提升。进一步利用静电纺丝法制备聚氨酯负载MCeO₂纤维膜,在高负载量情况下,修饰后的MCeO₂仍能在聚氨酯基中保持良好的分散性,且催化脱磷效率明显优于未修饰样品。CCK-8实验证实材料具有优异的细胞相容性,碱性磷酸酶染色结果进一步表明该纤维膜具有良好的成骨诱导潜力。本研究为开发兼具优异分散性和高效催化脱磷活性的纳米复合生物材料提供了重要依据。

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	李玉萍
	赵青
	章金正
	雷晓宇
	李丽
	木波
	杜青达
	李玉宝
	汪建
	左奕

关键词: 氧化铈纳米颗粒柠檬酸钠修饰电纺聚氨酯基纤维分散性催化脱磷活性

Abstract: Cerium oxide nanoparticles (CeO₂ NPs) were synthesized via a chemical precipitation method and subsequently surface-modified with sodium citrate (MCeO₂) to enhance their dispersibility and enzyme-mimetic catalytic properties. Morphological characterization was performed using transmission electron microscopy (TEM), while X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy were employed for semi-quantitative analysis of Ce³⁺ content and relative oxygen vacancy concentration. The findings show that although the citrate modification reduces both Ce³⁺ content and oxygen vacancy concentration, it significantly improves the catalytic dephosphorylation activity and dispersibility of MCeO₂. Further fabrication of polyurethane-supported MCeO₂ fiber membranes via electrospinning demonstrates that the modified MCeO₂ maintains excellent dispersibility within the polymer matrix even at high loading concentrations, while exhibiting markedly superior catalytic dephosphorylation efficiency compared to unmodified sample. CCK-8 assays confirm good cytocompatibility, and alkaline phosphatase staining further reveals the osteogenic induction potential of these fiber membranes. This study provides valuable insights for developing nanocomposite biomaterials with optimal dispersibility and efficient catalytic dephosphorylation activity.

Key words: cerium oxide nanoparticles sodium citrate modification electrospun polyurethane-based fiber dispersibility catalytic dephosphorization activity

出版日期: 2025-11-10 发布日期: 2025-11-10

ZTFLH:

TB32

基金资助: 国家重点研发计划(2021YFA1201300;2021YFA1201304);四川省国际科技创新合作项目(2024YFHZ0308)

通讯作者: *左奕,四川大学分析测试中心研究员、博士研究生导师。目前主要开展纳米有机/无机复合生物材料研究,包括磷灰石晶体机制研究;高分子及其复合活性材料的制备及评价;超细电纺纤维制备及应用研究;组织工程支架及降解聚合物载药控释等方向的研究。zoae@scu.edu.cn

作者简介: 李玉萍,四川大学分析测试中心硕士研究生,主要研究领域为纳米生物材料。

引用本文:

李玉萍, 赵青, 章金正, 雷晓宇, 李丽, 木波, 杜青达, 李玉宝, 汪建, 左奕. 修饰纳米CeO₂的制备及其复合纤维膜对体外磷活性影响研究[J]. 材料导报, 2025, 39(21): 25040225-7.
LI Yuping, ZHAO Qing, ZHANG Jinzheng, LEI Xiaoyu, LI Li, MU Bo, DU Qingda, LI Yubao, WANG Jian, ZUO Yi. Fabrication of Modified Nano-CeO₂ and Their Composite Fibrous Membranes for Enhanced Phosphorus Activity: an in vitro Study. Materials Reports, 2025, 39(21): 25040225-7.

链接本文:

https://www.mater-rep.com/CN/10.11896/cldb.25040225 或 https://www.mater-rep.com/CN/Y2025/V39/I21/25040225

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